Impacts of the overexpression of a tomato translationally controlled tumor protein (TCTP) in tobacco revealed by phenotypic and transcriptomic analysis

Carvalho, Marcelo; Acencio, Márcio Luís; Laitz, Alessandra Vasconcellos Nunes; Araújo, Laura Migliorini de; Arcuri, Mariana de Lara Campos; Nascimento, Leandro Costa do; Maia, Ivan de Godoy

doi:10.1007/s00299-017-2117-0

Cited by 13 publications

(9 citation statements)

References 48 publications

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“…The importance of TCTP in biological stress reactions was also demonstrated in non-mammalian systems. De Carvalho et al overexpressed TCTP from tomatoes in tobacco plants, which resulted in an increased growth rate and an improved performance under salt and osmotic stress conditions [48]. The transgenic plants displayed an increased expression of genes involved in photosynthesis, fatty acid metabolism, and water transport, and this was paralleled by an increased photosynthetic rate.…”

Section: Biological Stress Reactions and Autophagymentioning

confidence: 99%

Dysregulation of TCTP in Biological Processes and Diseases

Bommer

Telerman

2020

Cells

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Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF) or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is involved in a range of basic cell biological processes, such as promotion of growth and development, or cellular defense in response to biological stresses. Cellular TCTP levels are highly regulated in response to a variety of physiological signals, and regulatory mechanism at various levels have been elucidated. Given the importance of TCTP in maintaining cellular homeostasis, it is not surprising that dysregulation of this protein is associated with a range of disease processes. Here, we review recent progress that has been made in the characterisation of the basic biological functions of TCTP, in the description of mechanisms involved in regulating its cellular levels and in the understanding of dysregulation of TCTP, as it occurs in disease processes such as cancer.

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Section: Biological Stress Reactions and Autophagymentioning

confidence: 99%

Dysregulation of TCTP in Biological Processes and Diseases

Bommer

Telerman

2020

Cells

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“…A new study extended these investigations. De Carvalho and colleagues expressed tomato TCTP in tobacco plants and, by transcriptomics analysis, studied the pathways that are differentially regulated as a result of TCTP overexpression (de Carvalho et al 2017). They observed that genes involved in photosynthesis, fatty acid metabolism and water transport are up-regulated, while genes involved in the synthesis of the phytohormone ethylene were downregulated.…”

Section: Note Added In Proofmentioning

confidence: 99%

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

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“…The importance of TCTP in abiotic stress response of plants has been reported not only for its differential expression (Ermolayev et al, 2003;Vincent et al, 2007;Guo et al, 2012), but also by recombinant protein functional analysis in a host organism (Wang et al, 2012;Santa Brígida et al, 2014) and evaluation by silencing (Cao et al, 2012) and/or over-expression (Kim et al, 2012;Wang et al, 2015;de Carvalho et al, 2017) in transgenic plants. As example, cabbage plants silenced for the BoTCTP gene presented vegetative growth reduction and decrease of cold, high temperature and salinity tolerance (Cao et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, studies have reported the TCTP roles in response to abiotic stresses by its increased transcript levels under salt stress (Qin et al, 2011;Guo et al, 2012;Li et al, 2013;Santa Brígida et al, 2014), extremes of temperature (Cao et al, 2010), drought (Kim et al, 2012), and mercury (Wang et al, 2015) stress conditions. In addition, the TCTP relationship with abiotic stress has been also evidenced by silencing (Cao et al, 2010) and/or over-expression (Kim et al, 2012;Wang et al, 2015;de Carvalho et al, 2017) of TCTP genes in transgenic plants.…”

Section: Introductionmentioning

confidence: 99%