Impaired antioxidant activity in women with pre‐eclampsia

Sağol, Sermet; Özkinay, Erdinç; Özşener, Serdar

doi:10.1016/s0020-7292(98)00217-3

Cited by 81 publications

(58 citation statements)

References 14 publications

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“…After a further 30 years, Mikhail et al (1994) reported that plasma levels of reduced ascorbic acid are markedly decreased in patients with mild and severe preeclampsia. The association between decreased ascorbate and pre-eclampsia has been confirmed by several other studies (Hubel et al 1997;Sagol et al 1999;Panburana et al 2000;Chappell et al 2002a;Llurba et al 2004).…”

Section: The Maternal Circulation and Oxidative Stresssupporting

confidence: 54%

Could antioxidant supplementation prevent pre-eclampsia?

Holmes

McCance

2005

Proc. Nutr. Soc.

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Pre-eclampsia is a disorder characterised by pregnancy-induced hypertension and new-onset proteinuria occurring in the second half of pregnancy. Worldwide, approximately 2-3% of all pregnant women develop pre-eclampsia. The condition is a major cause of maternal and fetal morbidity and mortality. Abnormal placentation is an important predisposing factor for preeclampsia, while endothelial activation appears to be central to the pathophysiological changes, possibly indicative of a two-stage disorder characterised by reduced placental perfusion and a maternal syndrome. There is increasing evidence that pre-eclampsia is associated with both increased oxidative stress and reduced antioxidant defences, which has led to the hypothesis that oxidative stress may play an important role in the pathogenesis of pre-eclampsia, perhaps acting as the link in a two-stage model of pre-eclampsia. In support of this hypothesis a small, but important, preliminary study has shown a highly significant (P = 0 . 02) reduction in the incidence of pre-eclampsia in women at risk who were taking a supplement of vitamins C and E from midpregnancy. Furthermore, these findings support the hypothesis that oxidative stress is at least partly responsible for the endothelial dysfunction of pre-eclampsia. Several larger multicentre trials are currently underway to evaluate the efficacy, safety and cost benefits of antioxidant supplementation during pregnancy for the prevention of pre-eclampsia in both low-and high-risk women, including women with diabetes. The results of these trials are awaited with interest.Antioxidants: Pre-eclampsia: Oxidative Stress: Pregnancy: Diabetes Chappell et al. (1999) have reported in a small, but important, study a highly-significant reduction in the incidence of pre-eclampsia in women at risk who were taking a vitamin C and E supplement (adjusted odds ratio 0 . 39 (95 % CI 0 . 17, 0 . 90), P = 0 . 02). Antioxidant supplementation in these women has also been shown to be associated with changes in indices of oxidative stress and placental function (Chappell et al. 2002b). Primarily, the results of this trial indicate that antioxidants may be beneficial in the prevention of pre-eclampsia and support the emerging concept that oxidative stress plays a role in the pathophysiology of pre-eclampsia. Several multicentre trials are currently underway to confirm these results in larger groups of both low-risk and high-risk women. The present review gives an overview of pre-eclampsia, discusses the role of oxidative stress in the pathophysiology of this disorder and illustrates why antioxidants may play a role in pre-eclampsia prophylaxis. Pre-eclampsiaPre-eclampsia is a disorder of pregnancy characterised by pregnancy-induced hypertension ( ‡ 140 mmHg systolic and/or ‡ 90 mmHg diastolic blood pressure) and newonset proteinuria ( ‡ 300 mg protein/d) occurring in the second half of pregnancy (Brown et al. 2001). Preeclampsia has several predisposing risk factors including: primiparity; age <20 years or > 40 years; high BMI; per...

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Section: The Maternal Circulation and Oxidative Stresssupporting

confidence: 54%

Could antioxidant supplementation prevent pre-eclampsia?

Holmes

McCance

2005

Proc. Nutr. Soc.

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“…Antioxidants, due to their ability to scavenge free radicals, have been postulated to protect endothelial cell membranes against free radical-induced damage in preeclampsia [3][4][5]. There is evidence of a deficiency in protective antioxidant systems or increased utilization of antioxidants in preeclamptic compared with normal pregnancies [5,6]. Previous studies of plasma antioxidants in preeclampsia have primarily focused on carotenoids, vitamin E, vitamin C, thiols and sera antioxidant activity [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence of a deficiency in protective antioxidant systems or increased utilization of antioxidants in preeclamptic compared with normal pregnancies [5,6]. Previous studies of plasma antioxidants in preeclampsia have primarily focused on carotenoids, vitamin E, vitamin C, thiols and sera antioxidant activity [6][7][8][9][10]. Supplementation with vitamins E and C in women at risk of preeclampsia showed significant beneficial effects [11].…”

Section: Introductionmentioning

confidence: 99%

Lipid-Soluble Antioxidants and Pregnancy: Maternal Serum Levels of Coenzyme Q<sub>10</sub>, α-Tocopherol and γ-Tocopherol in Preeclampsia and Normal Pregnancy

Palan

Shaban

Martino

et al. 2004

Gynecol Obstet Invest

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It has been hypothesized that in preeclampsia, the antioxidant-deficient state may facilitate increased attacks of free radicals, which may result in endothelial cell damage. The purpose of this study was to investigate the association of three lipid-soluble antioxidants, coenzyme Q₁₀, α-tocopherol and γ-tocopherol, with preeclampsia and normal pregnancy. Serum levels of all three antioxidants in 42 women with normal pregnancies, 25 with mild preeclampsia and 28 with severe preeclampsia were measured by high-pressure liquid chromatography. A significant decrease was observed in serum levels of coenzyme Q₁₀ and α-tocopherol (p < 0.001 for each by the Kruskal-Wallis rank test) in women with preeclampsia compared to levels in normal pregnancy. γ-Tocopherol levels were comparable among the different groups. Logistic regression analysis revealed significant association between grades of preeclampsia and both serum coenzyme Q₁₀ and α-tocopherol levels (p = 0.000 and 0.030, respectively). Coenzyme Q₁₀ and α-tocopherol are potent antioxidants, and the decreased levels of these two antioxidants in preeclampsia may alter the normal redox balance, thereby reducing the ability of antioxidant defenses to protect against free radical damage. This could be a factor in the endothelial cell damage observed in preeclampsia.

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“…Pre eclampsia is a major contributor to premature births and intrauterine growth restriction. 13 The concentrations of Malondialdehyde (MDA) in Pregnancy induced hypertensive cases were significantly elevated in comparison with controls (p < 0.001) in maternal blood due to increased placental production of lipid peroxides. Lipid Peroxidation results in primary lipid Peroxidation products such as lipid hydro peroxides and secondary products such as malondialdehyde and lipid peroxides Plasma triglycerides in maternal blood in Pregnancy induced Hypertension were significantly higher than the control values (p < 0.001) Plasma Total Cholesterol in maternal blood shows a significant rise in Pregnancy induced hypertension cases against control (p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Study of Oxidative Stress in Pregnency Induced Hypertension (Pih)

B¹,

M²

2015

jemds

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Hypertensive disorders complicating pregnancy are common and form one of the deadly triad, along with hemorrhage and infection that contribute greatly to maternal morbidity and mortality. The present study was conducted in the Department of Biochemistry, Rangaraya Medical College, Kakinada, and Andhra Pradesh. The present study was undertaken to determine the changes in lipid peroxidation and lipoprotein concentrations in cord blood and maternal blood of pregnancy induced Hypertensive group consists of 50 pregnant women during delivery. In the present study the concentrations of Malondialdehyde (MDA) in Pregnancy induced hypertensive cases were significantly elevated in comparison with controls (p < 0.001) the same observation was reported in many studies. Fasting serum triglycerides correlate with serum malondialdehyde in women with preeclampsia. Plasma triglycerides in maternal blood in Pregnancy induced Hypertension were significantly higher than the control values ( p < 0.001) Plasma Total Cholesterol in maternal blood shows a significant rise in Pregnancy induced hypertension cases against control ( p < 0.001).

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Impaired antioxidant activity in women with pre‐eclampsia

Cited by 81 publications

References 14 publications

Could antioxidant supplementation prevent pre-eclampsia?

Could antioxidant supplementation prevent pre-eclampsia?

Lipid-Soluble Antioxidants and Pregnancy: Maternal Serum Levels of Coenzyme Q<sub>10</sub>, α-Tocopherol and γ-Tocopherol in Preeclampsia and Normal Pregnancy

Study of Oxidative Stress in Pregnency Induced Hypertension (Pih)

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