Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke

Li, Shanshan; Wang, Yao; Jiang, Ze D.; Huai, Yaping; Liao, James K.; Lynch, Kaari A.; Zafonte, Ross; Wood, Lisa J.; Wang, Qing Mei

doi:10.1097/phm.0000000000000904

Cited by 21 publications

(9 citation statements)

References 29 publications

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“…The test distinguishes motor functions and sensorimotor deficits caused by unilateral lesions placed in distinct areas of the rat somatic sensorimotor cortex (the caudal forelimb region, rostral forelimb region, or anteromedial cortex) ( Barth et al, 1990 ; Fleming et al, 2013 ; Li et al, 2018 ). This measure is also the only test with sufficient sensitivity to reveal long-term deficits caused by relatively small brain lesions ( Bouet et al, 2009 ).…”

Section: Methodsmentioning

confidence: 99%

Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3β signaling

Hung

Chung

Luo

et al. 2022

Front. Cell. Neurosci.

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BackgroundAcupuncture or electroacupuncture (EA) appears to be a potential treatment in acute clinical traumatic brain injury (TBI); however, it remains uncertain whether acupuncture affects post-TBI histone deacetylase (HDAC) expression or impacts other biochemical/neurobiological events.Materials and methodsWe used behavioral testing, Western blot, and immunohistochemistry analysis to evaluate the cellular and molecular effects of EA at LI4 and LI11 in both weight drop-impact acceleration (WD)- and controlled cortical impact (CCI)-induced TBI models.ResultsBoth WD- and CCI-induced TBI caused behavioral dysfunction, increased cortical levels of HDAC1 and HDAC3 isoforms, activated microglia and astrocytes, and decreased cortical levels of BDNF as well as its downstream mediators phosphorylated-Akt and phosphorylated-GSK-3β. Application of EA reversed motor, sensorimotor, and learning/memory deficits. EA also restored overexpression of HDAC1 and HDAC3, and recovered downregulation of BDNF-associated signaling in the cortex of TBI mice.ConclusionThe results strongly suggest that acupuncture has multiple benefits against TBI-associated adverse behavioral and biochemical effects and that the underlying mechanisms are likely mediated by targeting HDAC overexpression and aberrant BDNF-associated Akt/GSK-3 signaling.

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Section: Methodsmentioning

confidence: 99%

Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3β signaling

Hung

Chung

Luo

et al. 2022

Front. Cell. Neurosci.

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“…Animal models of large artery stiffness on the other hand, allow researchers to better investigate the causative mechanisms linking both diseases, though each with their own strengths and limitations. Examples include murine models with a partial or complete eNOS deletion ( Austin et al, 2013 ; Tan et al, 2015 ; Li et al, 2018 ; Austin and Katusic, 2020 ), displaying heterozygous fibrillin 1 ( Leloup et al, 2018 ) and elastin ( Hughes et al, 2014 ; Said et al, 2018 ), carotid artery calcification ( Muhire et al, 2019 ; Neuner et al, 2019 ), and transverse aortic constriction ( Demer and Tintut, 2008 ; Steppan et al, 2012 ; Cooper and Mitchell, 2016 ). Common symptoms in these rodents comprise an increased (neuro)inflammatory state, changes in cerebrovascular structure and/or blood flow and a dementia phenotype alongside altered arterial stiffening and blood pressure features ( Figure 2 ).…”

Section: Link Between Arterial Stiffness and Alzheimer’s Diseasementioning

confidence: 99%

Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer’s Disease

Hendrickx

Martinet

Dam

et al. 2021

Front. Mol. Biosci.

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The average age of the world’s elderly population is steadily increasing. This unprecedented rise in the aged world population will increase the prevalence of age-related disorders such as cardiovascular disease (CVD) and neurodegeneration. In recent years, there has been an increased interest in the potential interplay between CVDs and neurodegenerative syndromes, as several vascular risk factors have been associated with Alzheimer’s disease (AD). Along these lines, arterial stiffness is an independent risk factor for both CVD and AD. In this review, we discuss several inflammaging-related disease mechanisms including acute tissue-specific inflammation, nitro-oxidative stress, impaired autophagy, and insulin resistance which may contribute to the proposed synergism between arterial stiffness and AD.

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“…El factor neurotrópico derivado del cerebro es una neurotrofina abundante en el cerebro que es esencial para la neurogénesis y la recuperación funcional de las habilidades cerebrales. Se ha demostrado que esta molécula está regulada por el ON endotelial y que en ratones con una disfunción endotelial donde esta molécula se encontraba baja, la recuperación después de un ictus tuvo peor prognosis (17).…”

Section: Neuroreparación Posterior Al Ictusunclassified

Rol del óxido nítrico en la fisiopatología del ictus cerebral

Agudelo¹,

Corrales²,

Jara³

2020

Rev.méd.sinerg.

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En el ictus cerebral ocurren múltiples procesos fisiopatológicos complejos que determinan el daño cerebral primario y secundario. El óxido nítrico cumple un papel fundamental en la fisiopatología del ictus, representa es un componente primario en su desarrollo y progresión. Está íntimamente relacionado con la activación de la cascada inflamatoria, la alteración de la función mitocondrial, la angiogénesis y la neurogénesis. Estos últimos dos procesos son fundamentales para la neurorreparación posterior al ictus por lo cual han sido ampliamente estudiados. Las tres vías de producción del óxido nítrico se ven involucradas. El óxido nítrico puede desempeñarse como un agente perjudicial o protector dependiendo de donde se produzca.

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Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke

Abstract: This study's data support a role for eNOS in cognitive performance after stroke. This finding may lead to the development of novel interventions to treat poststroke cognitive deficits.

Cited by 21 publications

References 29 publications

Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3β signaling

Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3β signaling

Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer’s Disease

Rol del óxido nítrico en la fisiopatología del ictus cerebral

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