Impaired Conflict Detection Differentiates Suicide Attempters From Ideating Nonattempters: Evidence From Event-Related Potentials

Albanese, Brian J.; Macatee, Richard J.; Gallyer, Austin J.; Stanley, Ian H.; Joiner, Thomas E.; Schmidt, Norman B.

doi:10.1016/j.bpsc.2019.05.015

Cited by 17 publications

(20 citation statements)

References 68 publications

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“…Electrophysiological responses to emotional stimuli also have been investigated in participants with suicidal thoughts and acts. Albanese et al [ 141 ] used a go/no-go task to distinguish participants with suicidal ideation from those who had made a suicide attempt. They found participants with a history of suicide attempts exhibited deficits in detecting “the need for inhibitory control,” as indexed by a more positive change in the N2 response of the ERP.…”

Section: Discussionmentioning

confidence: 99%

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Ehlers

Wills

Karriker‐Jaffe

et al. 2020

Behavioral Sciences

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Alcohol exposure typically begins in adolescence, and heavy binge drinking is associated with health risk behaviors. Event-related oscillations (EROs) may represent sensitive biomarkers or endophenotypes for early alcohol exposure as well as other risk behaviors such as suicidal thoughts and actions. In this study, young adults (age 18–30 years) of American Indian (AI) (n = 479) and Mexican American (MA) (n = 705) ancestry were clinically assessed, and EROs were generated to happy, sad and neutral faces. Extreme adolescent binge drinking (10+ drinks) was common (20%) in this population of AI/MA and associated with a significantly increased risk of a lifetime history of suicidal acts (SA, suicide attempts, deaths) but not suicidal thoughts (ST, ideation, plans). ST were reported among MA participants, whereas SA were more common among AI young adults. Extreme adolescent binge drinking was also associated with errors in detection of sad and neutral faces, increases in delta ERO energy, and decreases in phase locking (PL), particularly in parietal areas. A lifetime history of ST was associated with increases in delta ERO energy and PL, whereas SA were associated with decreases in both. These studies suggest that ERO measures may represent important potential biomarkers of adolescent extreme binge drinking and risk for suicidal behaviors.

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Section: Discussionmentioning

confidence: 99%

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Ehlers

Wills

Karriker‐Jaffe

et al. 2020

Behavioral Sciences

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“…As others have noted (Franklin et al, 2017;Gibb & Tyspes, 2019), any single indicator is unlikely to accurately predict future suicide risk. Therefore, the TB LPP should be examined along with other risk factors such as diminished external threat responsivity (e.g., Bauer et al, 2020;Weinberg et al, 2017), cognitive control impairments (Albanese, Macatee, Gallyer, et al, 2019), and abnormal reward responses (Tsypes, Owens, & Gibb, 2019Tyspes, Owens, & Gibb, 2021 to gain a more comprehensive understanding of neurobehavioral suicide risk factors.…”

Section: Discussionmentioning

confidence: 99%

Thwarted belongingness predicts greater neural reactivity to a novel social exclusion image set: Evidence from the late positive potential

Albanese

Capron

Macatee

et al. 2021

Suicide & Life Threat Behav

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Introduction: Thwarted belongingness (TB) is among the most well-researched risk factors for suicidal ideation (SI). Yet, there is little research examining neural mechanisms underlying this construct. The present study used a novel social exclusion image set in concert with the late positive potential (LPP) to test the role of neural reactivity social exclusion in TB and SI.Methods: Participants (n = 243) were recruited based on elevated suicide risk and completed an emotional picture viewing task. The LPP was used to index neural reactivity to a novel set of social exclusion images and international affective picture system (IAPS) neutral, positive, and negative images. Results:Greater TB predicted a larger social exclusion ΔLPP (social exclusion LPP relative to neutral LPP) and social exclusion LPP even when accounting for SI, biological sex, age, negative affect, and perceived burdensomeness. Moreover, the social exclusion LPP was uniquely related to TB beyond the LPP to other images. Last, a larger social exclusion LPP predicted greater SI via elevations in TB. Conclusion:Reactivity to social exclusion stimuli may play an important role in SI via elevated TB, but not perceived burdensomeness. Future research should further explore the neural mechanisms underlying other IPT constructs.

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“…Improving affect‐regulation and reflective functioning emerged as a broad theme. Difficulties in self‐regulation are evident across diagnostic categories (Cuthbert & Insel, 2010, 2013; Cuthbert & Kozak, 2013; Hayes et al, 2019; Hofmann & Hayes, 2019; Kotov et al, 2017; Ruggero et al, 2019) and are well documented in suicidal youth (Albanese et al, 2019a, 2019b; Miller et al, 2017; Turecki et al, 2019). Compared to adults, adolescents are more likely to react to situations based on their emotional state (Arain et al, 2013; Choudhury, Blakemore, & Charman, 2006; Peper, van den Heuvel, Mandl, Pol, & van Honk, 2011; Sales & Irwin, 2009; Somerville, Fani, & McClure‐Tone, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…For example, most of the supported interventions include nonsuicidal self‐injury, suicidal ideation and suicide attempts as a unitary construct; although when outcomes are partitioned for these different behaviours, interventions are not statistically significant at reducing suicide attempts (Calati & Courtet, 2016; Glenn, Esposito, Porter, & Robinson, 2019; Ougrin et al, 2015). Although suicidal behaviours may exist along a continuum (Rossouw & Fonagy, 2012; Vrouva, Fonagy, Fearon, & Roussow, 2010), there may be differences between the clinical profiles of people who engage in one type of behaviour versus another, which could have important implications for treatment (Albanese et al, 2019a, 2019b; Dougherty et al, 2009; Liu, Trout, Hernandez, Cheek, & Gerlus, 2017; Nagra, Lin, & Upthegrove, 2016). Understanding the mechanisms of change in therapy may clarify why interventions are effective or ineffective (Carper, Makover, & Kendall, 2017; Kazdin & Nock, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Clinician's experiences and observations of therapeutic processes could add to the evidence base and help improve clinical outcomes (Kazdin, 2007; Matua & Van Der Wal, 2015; McWilliams, Grenyer, & Shedler, 2018; Shedler, 2017; Smith, Flowers, & Larkin, 2009). Suicidal people are heterogeneous (Albanese et al, 2019a, 2019b; Dougherty et al, 2009; Liu et al, 2017; Nagra et al, 2016), and young people experiencing suicidality in particular are both less likely to seek help and have poorer clinical and functional outcomes than their nonsuicidal counterparts (Borges et al, 2010; Hom, Stanley, & Joiner, 2015; Iorfino et al, 2018). A more idiographic and contextually based approach to research would contribute to a better understanding of the causal processes of change in interventions (Carper et al, 2017; Hjelmeland & Knizek, 2019) and help improve clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Psychotherapy and youth suicide prevention: An interpretative phenomenological analysis of specialist clinicians' experiences

Janackovski

Deane

Hains

2020

Clin Psychology and Psychoth

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The study explored psychologists' experiences in delivering short‐term psychotherapy for suicidal adolescents and sought to clarify how these experiences fit with empirically supported interventions and the interpersonal psychological theory of suicide. Semistructured interviews were conducted with 12 psychologists' who provided short‐term psychotherapy in a suicide prevention programme for youth (12‐ to 25‐year‐olds). Interview transcripts were analysed using interpretative phenomenological analysis. Three superordinate themes were identified: (i) understand the experience and context of the suicidality and the importance of a formulation‐based approach to engagement and individualized treatment planning; (ii) involve broad support systems, and in particular families, to help the young person reduce feelings of burdensomeness and increase safety, connectedness and belonging; and (iii) improve affect regulation and reflective functioning, important not only for the young person but also for the support system to maximize the positive impact of supports via emotional coregulation and effective problem‐solving. Interventions and approaches as well as the potential underlying processes of change being targeted are discussed in light of these findings. As an example, the development of a suicide safety plan was an intervention that traversed these themes. When used as a process tool, it helped foster a collaborative, formulation, dimensional and biopsychosocial approach to treat psychopathology and suicidality and extended beyond the therapist–client dyad. Moreover, treatment needs to be extended beyond the therapist–client dyad to allow therapists to facilitate a systemic treatment response, as this was seen as a major component of interventions for suicidal youth.

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Impaired Conflict Detection Differentiates Suicide Attempters From Ideating Nonattempters: Evidence From Event-Related Potentials

Cited by 17 publications

References 68 publications

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Thwarted belongingness predicts greater neural reactivity to a novel social exclusion image set: Evidence from the late positive potential

Psychotherapy and youth suicide prevention: An interpretative phenomenological analysis of specialist clinicians' experiences

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