Impaired global and segmental myocardial deformation assessed by two-dimensional speckle tracking echocardiography in patients with vitamin B12 deficiency

Kaya, Zekeriya; Biçer, Asuman; Yalçın, Funda; Er, Arzu; Camuzcuoğlu, Aysun; Korkmaz, Nurhan; Sezen, Yusuf

doi:10.5603/cj.a2013.0059

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…The most common nutritional sources are whole grains, bread, and pulses, while fruits and vegetables, the fundamentals of the gluten-free regimen, are less valuable [ 1 , 2 ]. Thus, a human’s dietary habits are of great importance and can be remarkably detrimental if left unbalanced, as observed in our patient [ 12 ]. The patient had adopted a gluten-free diet, depleted of micronutrients, including vitamin B1, without any medical consultation or medically proven gluten-related disease, which resulted in cardiogenic shock on the grounds of perimyocarditis in the course of fulminant beriberi disease.…”

Section: Discussionmentioning

confidence: 89%

Vitamin B1 Deficiency and Perimyocarditis Fulminans: A Case Study of Shoshin Syndrome in a Woman Following an Unbalanced Dietary Pattern Followed by a Literature Review

Rohun

Dorniak²,

Młodziński³

et al. 2023

Life

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(1) Background: vitamin B1 level depletion, known as a beriberi syndrome, can lead to severe cardiovascular complications, from which perimyocarditis fulminans is one of the most severe. (2) Methods: this is a retrospective case study that includes an adult patient with clinical presentations of acute heart failure (HF) symptoms following perimyocarditis on the grounds of thiamine deficiency. (3) Results: A 49-year-old woman presented with acute HF symptoms due to perimyocarditis. The patient suddenly developed refractory cardiogenic shock with metabolic acidosis requiring maximal medical management, including an intra-aortic balloon pump and extracorporeal membrane oxygenation. Due to additional peripheral polyneuropathy, beriberi disease was suspected after excluding other possible causes of the patient’s condition. After administration of vitamin B1, clinical improvement in the patient’s condition and the resolution of metabolic abnormalities were observed, which ultimately confirmed the diagnosis of Shoshin syndrome caused by the implementation of a gluten-free diet without indications for its adherence. (4) Conclusions: Fulminant beriberi disease, although considered rare, is a life-threatening condition and should always be included in the differential diagnosis of critically ill patients, notably those with malnutrition. An unbalanced diet can be detrimental and have severe consequences, i.e., perimyocarditis fulminans. However, treatment with thiamine can significantly improve the patient’s cardiac function and restore hemodynamic and metabolic parameters.

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Section: Discussionmentioning

confidence: 89%

Vitamin B1 Deficiency and Perimyocarditis Fulminans: A Case Study of Shoshin Syndrome in a Woman Following an Unbalanced Dietary Pattern Followed by a Literature Review

Rohun

Dorniak²,

Młodziński³

et al. 2023

Life

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show abstract

“…Individuals with COPD are at risk of vitamin B 12 deficiency ( Solomon, 2016 ) and hyperhomocysteinemia (HyCy) ( Seemungal et al, 2007 ; Fimognari et al, 2009 ). Accordingly, HyCy is linked to numerous cardiovascular alteration ( Ganguly and Alam, 2015 ) including histological changes in the heart ( Piquereau et al, 2017 ), impaired global and segmental cardiac contractility ( Kaya et al, 2014 ), or increased N-terminal-pro-B-type natriuretic peptide (NT-proBNP) secretion ( Herrmann et al, 2007 ; Guéant Rodriguez et al, 2013 ). This prepropeptide is synthesized and stored as a high molecular weight mass propeptide from both the atria and ventricles, and released mainly under pressure/volume overload of the cardiac chambers, after cleavage of the active form of BNP, inducing natriuresis and vasodilatation ( Calzetta et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin B12 Supplementation and NT-proBNP Levels in COPD Patients: A Secondary Analysis of a Randomized and Controlled Study in Rehabilitation

2020

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Purpose There is evidence of complex interaction between vitamin B 12 (vB 12 ) level, hyperhomocysteinemia (HyCy), and natriuretic peptide secretion. Exercise training could also modulate such interaction. In this secondary analysis of a Randomized Clinical Trial performed in a chronic obstructive pulmonary disease (COPD) rehabilitation setting, our primary objective was to investigate the interaction between vB 12 supplementation, exercise training, and changes in NT-proBNP levels after 8 weeks of intervention. Secondary objectives were to explore the correlations between acute changes in NT-proBNP levels with (i) acute exercise and (ii) oxygen uptake ( V ’O 2 ) kinetics during rest-to-exercise transition. Methods Thirty-two subjects with COPD were randomized into four groups: Rehabilitation+vB 12 ( n = 8), Rehabilitation ( n = 8), vB 12 ( n = 8), or Maltodextrin( n = 8). They were evaluated at baseline and after 8 weeks, during resting and immediately after maximal exercise constant work-rate tests (CWTs, T lim), for NT-proBNP plasmatic levels. Results After interaction analysis, the supplementation with vB 12 significantly changed the time course of NT-proBNP responses during treatment ( p = 0.048). However, the final analysis could not support a significant change in NT-proBNP levels owing to high-intensity constant work-rate exercise ( p -value > 0.05). There was a statistically significant correlation between V ’O 2 time constant and ΔNT-proBNP values ( T lim – rest) at baseline ( p = 0.049) and 2 months later ( p = 0.015), considering all subjects ( n = 32). Conclusion We conclude that vB 12 supplementation could modulate NT-proBNP secretion. Moreover, possibly, the slower the initial V ’O 2 adjustments toward a steady-state during rest-to-exercise transitions, the more severe the ventricular chamber volume/pressure stress recruitment, expressed through higher NT-proBNP secretion in subjects with larger V ’O 2 time constants, despite unchanged final acute exercise-induced neurohormone secretion.

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The relationship between vitamin B12 levels and electrocardiographic ventricular repolarization markers

Yılmaz¹,

Kurt²,

Vural³

et al. 2022

Nutr Hosp

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Impaired global and segmental myocardial deformation assessed by two-dimensional speckle tracking echocardiography in patients with vitamin B12 deficiency

Abstract: (Cardiol J 2014; 21, 1: 60-66)

Cited by 3 publications

References 31 publications

Vitamin B1 Deficiency and Perimyocarditis Fulminans: A Case Study of Shoshin Syndrome in a Woman Following an Unbalanced Dietary Pattern Followed by a Literature Review

Vitamin B1 Deficiency and Perimyocarditis Fulminans: A Case Study of Shoshin Syndrome in a Woman Following an Unbalanced Dietary Pattern Followed by a Literature Review

Vitamin B12 Supplementation and NT-proBNP Levels in COPD Patients: A Secondary Analysis of a Randomized and Controlled Study in Rehabilitation

The relationship between vitamin B12 levels and electrocardiographic ventricular repolarization markers

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