Impaired interhemispheric connectivity in medicationnaive patients with major depressive disorder

Xu, Ke; Jiang, Wenyan; Ren, Ling; Ouyang, Xuan; Jiang, Yifeng; Wu, Feng; Kong, Liang; Womer, Fay Y.; Liu, Zhening; Blumberg, Hilary P.; Tang, Yanqing; Wang, Fei

doi:10.1503/jpn.110132

Cited by 56 publications

(38 citation statements)

References 48 publications

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“…Suppressive ART may therefore be contributing to both depressive symptoms and to alterations in the CC. Incidentally, it may be relevant that measurable MTR and DTI changes in the CC have been reported in association with depression (Gunning-Dixon et al 2008; Benedetti et al 2011; Cole et al 2012; Guo et al 2012; Seok et al 2013; Xu et al 2013). Therapeutic ART could directly or indirectly result in CC changes, which in turn may manifest clinically as depression and functional difficulties.…”

Section: Discussionmentioning

confidence: 99%

Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

Kelly

Taiwo

et al. 2014

J. Neurovirol.

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Section: Discussionmentioning

confidence: 99%

Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

Kelly

Taiwo

et al. 2014

J. Neurovirol.

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“…Altered inter-hemispheric connectivity may be a hallmark of a number of psychiatric disorders and has been reported in autism (Lo et al, 2011), depression (Xu et al, 2012) and anxiety (Compton et al, 2008). It has also been found in disorders of consciousness (Ovadia-Caro et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression

Guo

Kendrick

Zhang

et al. 2013

NeuroImage: Clinical

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Schizophrenia is associated with disconnectivity in the brain although it is still unclear whether changes within or between hemispheres are of greatest importance. In this paper, an analysis of 152 schizophrenia patients compared with 122 healthy controls was carried out. Comparisons were also made with 39 depression patients and 37 controls to examine whether brain-wide changes in inter- or intra-hemispheric functional connectivity are most associated with the disorder and can distinguish it from depression. The authors developed new techniques (first and second order symmetry) to investigate brain-wide changes in patients (45 regions per hemisphere) and their association with illness duration and symptom severity. Functional connectivity between the same regions in left- and right-hemispheres (first order symmetry) was significantly reduced as was that between the same pairs of regions in the left- and right-hemispheres (second order symmetry) or using all possible inter-hemispheric connections in schizophrenia patients. By contrast, no significant changes were found for brain-wide intra-hemispheric links. First order symmetry changes correlated significantly with positive and negative symptom severity for functional connections linked via the anterior commissure and negative symptoms for those linked via the corpus callosum. Support vector machine analysis revealed that inter-hemispheric symmetry changes had 73–81% accuracy in discriminating schizophrenia patients and either healthy controls or depressed patients. In conclusion, reduced brain-wide inter-hemispheric functional connectivity occurs in schizophrenia, is associated with symptom severity, and can discriminate schizophrenia patients from depressed ones or healthy controls. Brain-wide changes in inter-hemispheric connections may therefore provide a useful potential biomarker for schizophrenia.

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“…83 One DTI study demonstrated that abnormalities in the structural integrity of the anterior genu of the CC may contribute to impairment of interhemispheric connectivity in medication-naive patients with MDD. 84 Therefore, FA reductions in the genu and body of the CC may indicate the functional impairment of frontal lobe information transfer between hemispheres and may be associated with impairment of working memory and emotion processing in patients with MDD. 83 A recent DTI study investigating the association between catechol-O-methyltransferase gene polymorphisms and white matter tract integrity in patients with MDD has found that MDD may be associated with the dysfunctional white matter changes in the CC, and the valine homozygote of catechol-O-methyltransferase gene may enhance these pathological changes.…”

Section: Fractional Anisotropy Reductions In the Corpus Callosummentioning

confidence: 99%

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging

Jiang

Zhao

et al. 2017

JPN

122

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Impaired interhemispheric connectivity in medicationnaive patients with major depressive disorder

Cited by 56 publications

References 48 publications

Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging

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