Impaired language performance as a precursor or consequence of Rolandic epilepsy?

Overvliet, Geke M.; Aldenkamp, Albert P.; Klinkenberg, Sylvia; Vles, J. S. H.; Hendriksen, Jos G.M.

doi:10.1016/j.jns.2011.02.009

Cited by 55 publications

(40 citation statements)

References 23 publications

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“…(Camfield and Camfield, 2014) However, there is growing evidence that points toward a less benign nature of this epilepsy syndrome in which affected children exhibit a variety of cognitive impairments (Danielsson and Petermann, 2009) linked largely but not exclusively to language function. (Datta et al, 2013; Overvliet et al, 2011b; Overvliet et al, 2013) Here we found that, compared to HC, new-onset drug-naïve BECTS patients exhibited increased ReHo while chronic BECTS on medication exhibited decreased ReHo in bilateral sensorimotor regions including the rolandic cortex, the putative source for abnormal epileptiform activity in BECTS. This result suggests that antiepileptic drugs (AEDs) may reverse this abnormal activity observed in the new-onset drug-naïve BECTS and even reach a lower level when compared with HC.…”

Section: Discussionmentioning

confidence: 61%

“…Some studies have found correlations between motor and language processes in children with BECTS suggesting that disruptions in sensorimotor regions are indeed negatively affecting aspects of language. (Besseling et al, 2013; Overvliet et al, 2011b) Specifically, Besseling et al found a reduction in functional connectivity between Broca’s and the rolandic network, which they hypothesized, was due to the link between epileptiform activity in sensorimotor cortex and language difficulties. (2013) Our results show that regional coherence in treated chronic BECTS patients approach normal patterns in the sensorimotor regions but continue to exhibit abnormal coherence patterns in the language regions.…”

Section: Discussionmentioning

confidence: 99%

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Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study

et al. 2015

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Objective The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data. Methods Resting state fMRI data was collected from three groups of children aged 6 to13, including new onset drug naïve BECTS, chronic BECTS with medication, and HC; the data analyzed by ReHo method. Mandarin school exams scores were acquired and compared across groups. Results There were three main findings. Firstly, compared with HC, abnormally increased ReHo was observed in bilateral sensorimotor regions in new onset BECTS which normalized or even reversed in the chronic BECTS group. Secondly, enhanced ReHo was found in the left frontal language region in the two BECTS groups, with even higher ReHo value in the chronic group. Lastly, decreased ReHo was found in regions of the default mode network (DMN), bilateral occipital lobes and cerebellum in both the new onset and chronic BECTS groups, lower in chronic BECTS. Behavioral analyses of school scores showed the chronic BECTS group presented significantly lower scores compared to HC (p < .05). Significance The coherence of low frequency fluctuations is disrupted in sensorimotor, language and DMN-related regions in new-onset BECTS. Some of these effects seem to be selectively normalized in chronic BECTS, thus allowing us to explore possible chronicity and AED-induced effects on BECTS. Abnormal ReHo in left language and DMN regions could be responsible for impairments of cognitive function.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study

et al. 2015

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“…The latter notably involves a range of impaired language abilities, such as oromotor deficits, problems in phonological awareness, compromised written language skills, reading disability, and speech sound disorder (Lundberg et al, 2005; Papavasiliou et al, 2005; Clarke et al, 2007; Northcott et al, 2007; Overvliet et al, 2011). These language impairments can clinically be of greater concern than the seizures, especially since they may persist after spontaneous seizure remission, which in RE is typically seen before the age of 16 years (Hommet et al, 2001; Panayiotopoulos et al, 2008; Monjauze et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Delayed convergence between brain network structure and function in rolandic epilepsy

Besseling

Jansen

Overvliet

et al. 2014

Front. Hum. Neurosci.

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Introduction: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE.Methods: Twenty-two children with RE (age, mean ± SD: 11.3 ± 2.0 y) and 22 healthy controls (age 10.5 ± 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01–0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis.Results: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization.Conclusion: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of epileptiform activity, and bear relevance for language function.

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“…For future research, we propose to follow up over many years, from the moment of seizure onset (or even before, e.g. based on the identification of a predictive profile of language impairment (Overvliet et al, 2011a(Overvliet et al, , 2011b) until well into adulthood. In addition to timely inclusion, adequate assessment of characteristics such as seizure frequency is expected to be especially challenging in such longitudinal studies of RE, given its mild and typically nocturnal seizure semiology.…”

Section: Methodological Considerationsmentioning

confidence: 99%

“…An often reported comorbidity of RE is language impairment (Monjauze et al, 2005;Northcott et al, 2007;Overvliet et al, 2010;Papavasiliou et al, 2005). It has been suggested that the diagnosis of language impairment may even precede that of RE (Overvliet et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

Early onset of cortical thinning in children with Rolandic epilepsy

Overvliet

Besseling

Jansen

et al. 2013

Journal of the Neurological Sciences

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Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers) Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Introduction: Rolandic epilepsy, a childhood epilepsy associated with language impairments, was investigated for language-related cortical abnormalities. Methods: Twenty-four children with rolandic epilepsy and 24 controls (age 8-14 years) were recruited and underwent the Clinical Evaluation of Language Fundamentals test. Structural MRI was performed at 3 T (voxel size 1 × 1 × 1 mm 3 ) for fully automated quantitative assessment of cortical thickness. Regression analysis was used to test for differences between patients and controls and to assess the effect of age and language indices on cortical thickness. Results: For patients the core language score (mean ± SD: 92 ± 18) was lower than for controls (106 ± 11, p = 0.0026) and below the norm of 100 ± 15 (p = 0.047). Patients showed specific impairments in receptive language index (87 ± 19, p = 0.002) and language content index (87 ± 18, p = 0.0016). Cortical thickness was reduced in patients (p b 0.05, multiple-comparisons corrected) in left perisylvian regions. Furthermore, extensive cortical thinning with age was found in predominantly left-lateralized frontal, centro-parietal and temporal regions. No associations were found between cortical thickness and language indices in the regions of aberrant cortex. Conclusion: The cortical abnormalities described represent subtle but significant pathomorphology in this critical phase of brain development (8-14 years) and suggest that rolandic epilepsy should not be considered merely a...

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Impaired language performance as a precursor or consequence of Rolandic epilepsy?

Cited by 55 publications

References 23 publications

Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study

Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTS): A resting state fMRI study

Delayed convergence between brain network structure and function in rolandic epilepsy

Early onset of cortical thinning in children with Rolandic epilepsy

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