Impaired left ventricular diastolic function during isometric exercise in asymptomatic patients with hyperlipidaemia

Salmasi, Abdul-Majeed; Fröst, Peter; Dancy, Mark

doi:10.1016/j.ijcard.2003.06.005

Cited by 15 publications

(10 citation statements)

References 47 publications

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“…Diastolic dysfunction has been found during exercise in patients with unchanged diastolic function at rest [35]. Thus, it is possible that during exercise and increased heart rate, our patients did present improved diastolic function following exercise training.…”

Section: Discussionmentioning

confidence: 83%

Combined exercise training in asymptomatic elderly with controlled hypertension: Effects on functional capacity and cardiac diastolic function

et al. 2012

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SummaryBackgroundAging is associated with changes in cardiac structure and function that are associated with left ventricular diastolic dysfunction. Whether diastolic functional alterations during senescence are manifestations of the intrinsic aging process or related to cardiac adaptations to a more sedentary lifestyle is still unsettled. This was a prospective study evaluating the effects of a 6-month combined exercise training period on functional capacity and diastolic function in sedentary elderly patients with controlled arterial hypertension.Material/MethodsFunctional capacity was assessed by exercise stress test and muscle strength was evaluated by the one-repetition maximum test. Cardiac structures and function were analyzed by transthoracic echocardiography.ResultsFifteen patients, 68±8 years old, completed the training program. Exercise training significantly improved physical capacity (distance walked: 551±92 vs. 630±153 m, P<0.05; work load: 7.2±1.7 vs. 8.5±3.0 METs, P<0.05) and upper and lower extremity muscle strength (P<0.001). Arterial blood pressure significantly decreased after training (systolic blood pressure: 134±9 vs. 128±8 mmHg; diastolic blood pressure: 82±7 vs. 77±6 mmHg; P<0.05). Cardiac structures and left and right systolic and diastolic function did not change after combined training (P>0.05).ConclusionsCombined and supervised training for a 6-month period increases physical capacity and muscle strength in elderly patients with controlled arterial hypertension without changing resting left ventricular diastolic function.

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Section: Discussionmentioning

confidence: 83%

Combined exercise training in asymptomatic elderly with controlled hypertension: Effects on functional capacity and cardiac diastolic function

et al. 2012

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“…Evidence of an exercise induced impairment of diastolic function caused by myocardial ischemia was found in patients with coronary artery disease [48] and angina pectoris [49]. Exercise induced diastolic dysfunction could also be found in patients with type 1 diabetes mellitus [4] and in patients with hyperlipidemia and a normal stress ECG [3]. It was hypothesized that exercise induced diastolic dysfunction in these patients might be an early sign of subclinical myocardial ischemia.…”

Section: Diastolic Dysfunction In Exercisementioning

confidence: 99%

“…Parameters that are used to evaluate diastolic function are usually obtained at rest. However, there is evidence that diastolic dysfunction can be present at exercise in patients with normal diastolic function at rest [3,4]. The finding of diastolic dysfunction by abnormal mechanical properties of the left ventricle in diastole does not imply the presence of clinical symptoms.…”

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confidence: 99%

Diastolic dysfunction in exercise and its role for exercise capacity

et al. 2008

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Diastolic dysfunction is frequent in elderly subjects and in patients with left ventricular hypertrophy, vascular disease and diabetes mellitus. Patients with diastolic dysfunction demonstrate a reduced exercise capacity and might suffer from congestive heart failure (CHF). Presence of symptoms of CHF in the setting of a normal systolic function is referred to as heart failure with normal ejection fraction (HFNEF) or, if evidence of an impaired diastolic function is observed, as diastolic heart failure (DHF). Reduced exercise capacity in diastolic dysfunction results from a number of pathophysiological alterations such as slowed myocardial relaxation, reduced myocardial distensibility, elevated filling pressures, and reduced ventricular suction forces. These alterations limit the increase of ventricular diastolic filling and cardiac output during exercise and lead to pulmonary congestion. In healthy subjects, exercise training can enhance diastolic function and exercise capacity and prevent deterioration of diastolic function in the course of aging. In patients with diastolic dysfunction, exercise capacity can be enhanced by exercise training and pharmacological treatment, whereas improvement of diastolic function can only be observed in few patients.

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“…Hypercholesterolaemia may sensitize the myocardium to the additional insults (e.g., haemodynamic overloading, myocardial ischaemia, diabetes) by altering the membrane lipid bilayer and disturbing intracellular calcium handling [43]. These changes may result in alterations in active relaxation, ventricular compliance, resulting in increased diastolic stiffness that impairment in left ventricular diastolic function may manifest before the exercise ECG becomes positive [44].…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of antilipidaemic therapy on left ventricular function in patients with dyslipidaemia: multigated radionuclide ventriculography study

Entok¹,

Ünalır²,

Çavuşoğlu³

et al. 2005

Nuclear Medicine Communications

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Impaired left ventricular diastolic function during isometric exercise in asymptomatic patients with hyperlipidaemia

Cited by 15 publications

References 47 publications

Combined exercise training in asymptomatic elderly with controlled hypertension: Effects on functional capacity and cardiac diastolic function

Combined exercise training in asymptomatic elderly with controlled hypertension: Effects on functional capacity and cardiac diastolic function

Diastolic dysfunction in exercise and its role for exercise capacity

Long-term effects of antilipidaemic therapy on left ventricular function in patients with dyslipidaemia: multigated radionuclide ventriculography study

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