Impaired Mechanical Response to Calcium of Diabetic Rat Hearts

Magnetic resonance imaging analysis of cardiac cycle events in diabetic rats: the effect of angiotensin‐converting enzyme inhibition

“…). The basic physiological parameters of body weight, blood glucose concentrations, heart rates and systolic blood pressures in both control and experimental groups agreed with earlier reports from this diabetic system (Pierce & Dhalla, 1981, 1983, 1985 a,b ; Afzal et al 1988; Maeda et al 1995; Shimabukuro et al 1995; Hicks et al 1998; Al‐Shafei et al 2002).…”

“…The findings obtained here are therefore comparable with earlier independent studies using the same model that used conventional invasive or ex vivo physiological techniques. These have included physiological studies of papillary muscle function (Fein et al 1980; Fein & Sonnenblick, 1994; Warley et al 1995), myocardial contraction and relaxation (Jackson et al 1985; Afzal et al 1988), diastolic and peak systolic pressures (Miller, 1979; Afzal et al 1988; Shimabukuro et al 1995; Rodrigues & McNeill, 1986; Paulson et al 1987; Lopaschuk & Spafford, 1989; Rodrigues et al 1988; Goyal et al 1998) and heart rates (Jackson & Carrier, 1983; Afzal et al 1988; Hicks et al 1998). Despite their rapid heart rates, the cine MRI methods successfully imaged both ventricles at twelve time points which substantially covered the cardiac cycle and completely covered the ventricular anatomy.…”

Decreased RhoA expression in myocardium of diabetic rats

“…Recent studies have suggested that diabetic patients may develop myocardial dysfunction in the absence of coronary heart disease and hypertension (Kita et al 1991). STZ-induced diabetic animals such as rats, dogs, and rabbits have an increased ratio of heart/body mass as well as prolonged myocardial contraction and relaxation (Fein et al 1985;Dai et al 1994;Shimabukuro et al 1995;Verma and McNeill 1994;Litwin et al 1990). The impaired cardiac function is suggested to result from abnormalities of the contractile and regulatory proteins in diabetic heart muscle (Malhotra and Sanghi 1997); however, the pathogenesis of diabetic cardiomyopathy remains unclear.…”

Non‐invasive magnetic resonance imaging assessment of myocardial changes and the effects of angiotensin‐converting enzyme inhibition in diabetic rats

“…For example, earlier anatomical studies examined for light microscopic evidence of interstitial fibrosis (Factor et al 1981) and ultrastructural changes (Jackson et al 1985; Warley et al 1995) over similar age periods. There have also been physiological studies of papillary muscle function (Fein et al 1980; Fein & Sonnenblick, 1994; Warley et al 1995), myocardial contraction and relaxation (Jackson et al 1985; Afzal et al 1988), diastolic and peak systolic pressures (Miller, 1979; Rodrigues & McNeill, 1986; Paulson et al 1987; Afzal et al 1988; Rodrigues et al 1988; Lopaschuk & Spafford, 1989; Shimabukuro et al 1995; Goyal et al 1998) and heart rates (Jackson & Carrier, 1983; Afzal et al 1988; Hicks et al 1998).…”