Impaired mineral metabolism in Cushing's syndrome: Parathyroid function, vitamin D metabolites and osteopenia.

Kugai, Nobuo; Koide, Yoshinobu; Yamashita, Kamejiro; Shimauchi, Takehide; Nagata, Noriko; Takatani, Osamu

doi:10.1507/endocrj1954.33.345

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…However, a recent study showed that PTH concentrations did not differ significantly between 12 dogs with PDH (before and after hypophysectomy) and control dogs (Corbee and others 2012). One possible explanation is that, in common with humans, the great variation in PTH concentrations in dogs with hyperadrenocorticism (HAC) may be due to the clinical stage of the disease (Kugai and others 1986). The pathogenesis of hyperphosphataemia in dogs with HC, a condition that is not observed in humans with Cushing's syndrome (Findling and others 1982, Faggiano and others 2003), remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for survival in dogs with pituitary‐dependent hypercortisolism treated with trilostane

et al. 2015

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Pituitary-dependent hypercortisolism (PDH) is one of the most frequent endocrinopathies in dogs, but prognostic factors are largely unknown. The aim of this retrospective case series study was to determine the prognostic value of different clinical and clinicopathological variables evaluated in dogs newly diagnosed with PDH that were subsequently treated with trilostane. Medical records from one referral centre were evaluated. Eighty-five dogs with PDH were included. The median survival time was 852 days (range 2-3210 days); 60/85 (70 per cent) and 25/85 (29 per cent) dogs survived more than one and three years, respectively. In multivariable model analysis the length of survival of older dogs (HR 1.24, 95% CI 1.09 to 1.40) and dogs with higher serum phosphate concentrations (HR 1.35, 95% CI 1.01 to 1.81) was shorter. Serum phosphate concentrations were above the reference range in 37/85 (44 per cent) of animals. Clinical signs, liver enzymes, serum cortisol concentrations of the endocrine tests, proteinuria, systolic hypertension, the presence of concomitant disorders, and the frequency of trilostane administration were not associated with survival time. Hyperphosphataemia is a common finding in dogs with newly diagnosed PDH and represents a negative prognostic factor.

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Section: Discussionmentioning

confidence: 99%

Prognostic factors for survival in dogs with pituitary‐dependent hypercortisolism treated with trilostane

et al. 2015

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“…Long‐term administration of prednisone at 1.5 mg/kg/day slightly decreases serum calcitriol concentrations, but not 25‐(OH)D concentrations, in healthy mixed‐breed dogs 28 . These findings are similar to what happens in humans undergoing long‐term steroid treatment or affected by naturally occurring Cushing's Syndrome, in which circulating concentrations of 25‐(OH)D and calcitriol are decreased or unchanged depending on the study 8,10,29‐31 . The controversial results reported in the human literature might be because of differences in the nature of the underlying diseases, the dose and duration of the glucocorticoid excess, and the degree of mineral bone disorders 32 .…”

Section: Discussionmentioning

confidence: 50%

“…are decreased or unchanged depending on the study. 8,10,[29][30][31] The controversial results reported in the human literature might be because of differences in the nature of the underlying diseases, the dose and duration of the glucocorticoid excess, and the degree of mineral bone disorders. 32 These hypotheses could also apply to the present results.…”

Section: Discussionmentioning

confidence: 99%

Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

Corsini

Dondi

Serio

et al. 2021

Veterinary Internal Medicne

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Background: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. Objectives: To evaluate circulating concentrations of whole parathormone (wPTH), 25-hydroxyvitamin D (25-(OH)D), calcitriol, and fibroblast growth factor-23 (FGF-23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. Animals: Twenty-three client-owned dogs with NOHC, and 12 client or staff-owned healthy dogs. Methods: Prospective cross-sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25-(OH)D, calcitriol and FGF-23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs.Results: Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03-2.44 vs 0.15%, range, 0.06-0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7-490 vs 24.6 pg/mL, range, 5.5-56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25-(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF-23 concentrations than controls (316.6 pg/mL, range, 120.8-575.6 vs 448.7 pg/mL, range, 244.8-753; P = .03).Conclusions and Clinical Importance: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism.

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“…However, subtle symptoms may have been present for a longer time but ignored by the patient. For example, presenting hypocalcemia and vitamin-D deficiency was likely a result of Cushing's syndrome 12,13 and strict vegetarian diet. His complaints of ''nasal stuffiness and sinus problems'' were attributed to a prior diagnosis of nasal polyps and sinusitis.…”

Section: Discussionmentioning

confidence: 99%

“…The scan also showed osteopenic-appearing vertebral bodies, 2 small benign-appearing lung nodules, and bilateral nodular enlargement of the adrenal glands. The adrenal findings led to the measurement of plasma cortisol of 123.5 lg/dL (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), ACTH 648 pg/mL (5-52), and urine-free cortisol of 11,640 lg/ day (20-90). The clinical picture was consistent with ectopic ACTH-dependent Cushing's syndrome (hyperpigmentation, volume overload, severe hypokalemia, and leukocytosis), and it was supported by the very high cortisol levels.…”

mentioning

confidence: 99%

Location of ectopic adrenocortical hormone‐secreting tumors causing Cushing's syndrome in the paranasal sinuses

et al. 2008

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Impaired mineral metabolism in Cushing's syndrome: Parathyroid function, vitamin D metabolites and osteopenia.

Cited by 12 publications

References 24 publications

Prognostic factors for survival in dogs with pituitary‐dependent hypercortisolism treated with trilostane

Prognostic factors for survival in dogs with pituitary‐dependent hypercortisolism treated with trilostane

Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

Location of ectopic adrenocortical hormone‐secreting tumors causing Cushing's syndrome in the paranasal sinuses

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