2021
DOI: 10.1111/all.15170
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Impaired skin barrier and allergic sensitization in early infancy

Abstract: Background Factors predicting allergic sensitization in the first 6 months of life are poorly understood. We aimed to determine whether eczema, dry skin, and high transepidermal water loss (TEWL) at 3 months were associated with allergic sensitization at 6 months of age and, secondarily, to establish whether these characteristics predicted sensitization from 3 to 6 months of age. Methods At 3 months of age, 1,994 infants from the population‐based PreventADALL birth cohort in Norway and Sweden were assessed for… Show more

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Cited by 42 publications
(35 citation statements)
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“…All three studies defined AS as an MWD of ≥2 mm to common food and inhalant allergens, while the SPT was read at 15 min in the COPSAC study [ 15 , 17 ] and at 10 min in the DARC cohort [ 16 ]. The prevalence of AS in our cohort is in line with the whole PreventADALL cohort of 1,994 children published previously (any sensitization 9.9%, food 8.9%, and inhalation 1.9%) [ 18 ]. The infants in our study were born almost 20 years after the two Danish infant populations [ 15 , 16 , 17 ].…”
Section: Discussionsupporting
confidence: 90%
“…All three studies defined AS as an MWD of ≥2 mm to common food and inhalant allergens, while the SPT was read at 15 min in the COPSAC study [ 15 , 17 ] and at 10 min in the DARC cohort [ 16 ]. The prevalence of AS in our cohort is in line with the whole PreventADALL cohort of 1,994 children published previously (any sensitization 9.9%, food 8.9%, and inhalation 1.9%) [ 18 ]. The infants in our study were born almost 20 years after the two Danish infant populations [ 15 , 16 , 17 ].…”
Section: Discussionsupporting
confidence: 90%
“…High TEWL: a mean TEWL value >8.83 g/m 2 /h (above the 75th percentile), in line with previous studies [24,44].…”
Section: Exposuressupporting
confidence: 90%
“…In AD, an inflammatory condition characterized by eczematous itchy skin lesions [15,21], reduced skin barrier function and dysregulation of the immune system play an important role [22,23]. Increased transepidermal water loss (TEWL), a non-invasive measurement of skin barrier function, has been associated with development of allergic sensitization [24,25] and AD [26,27], and has been shown to precede the clinical manifestations of AD [26,28]. Reduced skin barrier function may also play a role in the development and progression of asthma [29,30].…”
Section: Introductionmentioning
confidence: 99%
“…Warnberg и соавт. сделан вывод, что экзема, сухость кожи, высокая трансэпидермальная потеря воды являются предикторами аллергической сенсибилизации в возрасте 6 мес [10], что согласуется с полученными нами данными.…”
Section: оригинальная статья Original Articleunclassified