Impaired social cognition caused by perinatal protein malnutrition evokes neurodevelopmental disorder symptoms and is intergenerationally transmitted

Fesser, Estefanía A.; Gianatiempo, Octavio; Berardino, Bruno Gabriel; Alberca, Carolina D.; Urrutia, Leandro; Falasco, German; Sonzogni, Silvina V.; Chertoff, Mariela; Cánepa, Eduardo T.

doi:10.1016/j.expneurol.2021.113911

Cited by 6 publications

(4 citation statements)

References 68 publications

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“…Inadequate intake of nutrients can lead to cognitive impairment, especially in a young age. 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 The body weight of rat was closely monitored after surgery to ensure that the weight recovered and saw stable growth, which lasted for at least 2 weeks before MWM. The weight of rats in YC and OC groups recovered to the preoperative level after 2 and 13 days, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive decline in Sprague–Dawley rats induced by neuroplasticity changes after occlusal support loss

Wang,

Pang,

et al. 2024

CNS Neurosci Ther

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BackgroundTooth loss is closely related to cognitive impairment, especially affecting cognitive functions involving hippocampus. The most well‐known function of the hippocampus is learning and memory, and the mechanism behind is neuroplasticity, which strongly depends on the level of brain‐derived neurotrophic factor (BDNF). While research has delved into the possible mechanisms behind the loss of teeth leading to cognitive dysfunction, there are few studies on the plasticity of sensory neural pathway after tooth loss, and the changes in related indicators of synaptic plasticity still need to be further explored.MethodsIn this study, the bilateral maxillary molars were extracted in Sprague–Dawley rats of two age ranges (young and middle age) to establish occlusal support loss model; then, the spatial cognition was tested by Morris Water Maze (MWM). Quantitative real‐time PCR (qPCR) and Western Blotting (WB) were used to detect BDNF, AKT, and functional proteins (viz., PSD95 and NMDAR) of hippocampal synapses. Golgi staining was used to observe changes in ascending nerve pathway. IF was used to confirm the location of BDNF and AKT expressed in hippocampus.ResultsMWM showed that the spatial cognitive level of rats dropped after occlusal support loss. qPCR, WB, and IF suggested that the BDNF/AKT pathway was down‐regulated in the hippocampus. Golgi staining showed the neurons of ascending sensory pathway decreased in numbers.ConclusionOcclusal support loss caused plastic changes in ascending nerve pathway and induced cognitive impairment in rats by down‐regulating BDNF and synaptic plasticity.

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Section: Discussionmentioning

confidence: 99%

“…Inadequate intake of nutrients can lead to cognitive impairment, especially in a young age. [39][40][41][42][43][44][45][46] The body weight of rat was closely monitored after surgery to ensure that the weight recovered and saw stable growth, which lasted for at least 2 weeks before MWM.…”

Section: Discussionmentioning

confidence: 99%

Cognitive decline in Sprague–Dawley rats induced by neuroplasticity changes after occlusal support loss

Wang,

Pang,

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…Interestingly, a recent study showed that perinatal protein restriction in mice had transgenerational effects, impairing social motivation and recognition memory in F1 and F2 generations. The authors found reduced glucose metabolism in the prefrontal cortex and identified 21 autism-associated genes in an overall downregulated transcriptome ( 70 ).…”

Section: Neuroanatomical and Behavioral Consequencesmentioning

confidence: 99%

“…discovered that male mice subjected to perinatal malnutrition showed more anxiety-like behavior than females ( 52 ). Transcriptome analysis of the prefrontal cortices of mice exposed to perinatal protein deficiency revealed numerous dysregulated genes that were not shared between the sexes despite similar behavioral phenotypes ( 70 ). Other studies have shown comparable responses in both sexes.…”

Section: The Role Of Sex and Timingmentioning

confidence: 99%

Unraveling the Molecular Mechanisms of the Neurodevelopmental Consequences of Fetal Protein Deficiency: Insights From Rodent Models and Public Health Implications

Vancamp,

Frapin,

Parnet

et al. 2024

Biological Psychiatry Global Open Science

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Programming of future generations during breastfeeding: The intricate relation between metabolic and neurodevelopment disorders

2022

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Impaired social cognition caused by perinatal protein malnutrition evokes neurodevelopmental disorder symptoms and is intergenerationally transmitted

Cited by 6 publications

References 68 publications

Cognitive decline in Sprague–Dawley rats induced by neuroplasticity changes after occlusal support loss

Cognitive decline in Sprague–Dawley rats induced by neuroplasticity changes after occlusal support loss

Unraveling the Molecular Mechanisms of the Neurodevelopmental Consequences of Fetal Protein Deficiency: Insights From Rodent Models and Public Health Implications

Programming of future generations during breastfeeding: The intricate relation between metabolic and neurodevelopment disorders

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