Impaired Telomere Length and Telomerase Activity in Peripheral Blood Leukocytes and Granulosa Cells in Patients With Biochemical Primary Ovarian Insufficiency

Xu, Xiaofei; Chen, Xinxia; Zhang, Xiruo; Liu, Yi‐Xun; Wang, Zhao; Wang, Peng; Du, Yanzhi; Qin, Yingying; Chen, Zi‐Jiang

doi:10.1097/01.ogx.0000513118.72411.50

Cited by 21 publications

(33 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research has shown that extremely short telomeres may trigger a p53-dependent cell cycle arrest and cause DNA damage, which in turn activates cellular senescence pathways [115]. Another study indicated that the granulosa cells of women with primary ovarian insufficiency had lower telomerase activity and shorter telomeres, thereby demonstrating the potential application of telomerase activity and telomere length as molecular markers of ovarian insufficiency [116]. These results show that the normal aging process of oocytes is accompanied by telomere shortening, and pathological telomere shortening leads to the acceleration of oocyte aging.…”

Section: Telomere Shortening Causes Oocyte Agingmentioning

confidence: 99%

The Molecular Regulation in the Pathophysiology in Ovarian Aging

Lin

Tsai

et al. 2021

Aging and disease

View full text Add to dashboard Cite

The female reproductive system is of great significance to women's health. Aging of the female reproductive system occurs approximately 10 years prior to the natural age-associated functional decline of other organ systems. With an increase in life expectancy worldwide, reproductive aging has gradually become a key health issue among women. Therefore, an adequate understanding of the causes and molecular mechanisms of ovarian aging is essential towards the inhibition of age-related diseases and the promotion of health and longevity in women. In general, women begin to experience a decline in ovarian function around the age of 35 years, which is mainly manifested as a decrease in the number of ovarian follicles and the quality of oocytes. Studies have revealed the occurrence of mitochondrial dysfunction, reduced DNA repair, epigenetic changes, and metabolic alterations in the cells within the ovaries as age increases. In the present work, we reviewed the possible factors of aging-induced ovarian insufficiency based on its clinical diagnosis and performed an in-depth investigation of the relevant molecular mechanisms and potential targets to provide novel approaches for the effective improvement of ovarian function in older women.

show abstract

Section: Telomere Shortening Causes Oocyte Agingmentioning

confidence: 99%

The Molecular Regulation in the Pathophysiology in Ovarian Aging

Lin

Tsai

et al. 2021

Aging and disease

View full text Add to dashboard Cite

show abstract

“…Healthy follicles showed > amounts of TA, as compared to decreased GTA =>enhancement of atretic follicles [15]. Subjects having subtle and biochemical premature ovarian insufficiency (POI) further demonstrated reduced TA in their granulosa cells [16,17]. Overall these observations point that GTA might work as an ovarian function biomarker.…”

Section: Prmmsid000570 3(4)2020mentioning

confidence: 94%

How Can We Optimize the Granulose Cell Function of Oocytes from an Endometriosis Patient to Improve the Reproductive Outcomes-A Short Communication?

Kaur¹

2020

PRM

View full text Add to dashboard Cite

show abstract

“…In this respect, it has been reported that women with ovarian insufficiency presented shorter leukocyte telomeres than healthy controls. 62,63 Furthermore, when they studied, the granulose cells found a reduced TL and telomerase activity in these women. 62,63 Results established by Aydos et al who evidenced a significant relation between TL and women reproductive life span were consistent with this study.…”

Section: Disruption Of Telomere Homeostasis and Female Reproductive Problemsmentioning

confidence: 95%

“…62,63 Furthermore, when they studied, the granulose cells found a reduced TL and telomerase activity in these women. 62,63 Results established by Aydos et al who evidenced a significant relation between TL and women reproductive life span were consistent with this study. 13 This shows that an accelerated TL reduction may be related to an early loss of ovarian reserve and fertility capacity.…”

Section: Disruption Of Telomere Homeostasis and Female Reproductive Problemsmentioning

confidence: 95%

Understanding the Role of Telomere Dynamics in Normal and Dysfunctional Human Reproduction

Arias-Sosa

2018

Reprod Sci

View full text Add to dashboard Cite

In modern society, fertility problems and demand of treatment seem to be on the rise, which led to an increased interest in research regarding human reproduction. Among these efforts, the study of the molecular senescence process has gain notorious popularity as aging is one of the most important variables involved in reproductive capacity and since the comprehension of telomere dynamics has become an important and influential theme. This new knowledge regarding the reproductive aging process is expected to offer new tools to understand the acquisition, maintenance, and loss of fertility potential. Therefore, this review seeks to clarify the relevance of molecular aging (evaluated by telomere shortening) in human reproduction, showing that it is a dynamic and variable process modulated according to the specific tissue and stage of development. As well, it is discussed how telomere status influence the development and progression of some fertility pathologies, the outcome of assisted reproductive treatments, and programming of aging in the offspring.

show abstract

Impaired Telomere Length and Telomerase Activity in Peripheral Blood Leukocytes and Granulosa Cells in Patients With Biochemical Primary Ovarian Insufficiency

Cited by 21 publications

References 0 publications

The Molecular Regulation in the Pathophysiology in Ovarian Aging

The Molecular Regulation in the Pathophysiology in Ovarian Aging

How Can We Optimize the Granulose Cell Function of Oocytes from an Endometriosis Patient to Improve the Reproductive Outcomes-A Short Communication?

Understanding the Role of Telomere Dynamics in Normal and Dysfunctional Human Reproduction

Contact Info

Product

Resources

About