2016
DOI: 10.2147/copd.s113657
|View full text |Cite|
|
Sign up to set email alerts
|

Impaired training-induced adaptation of blood pressure in COPD patients: implication of the muscle capillary bed

Abstract: Background and aimsTargeting the early mechanisms in exercise-induced arterial hypertension (which precedes resting arterial hypertension in its natural history) may improve cardiovascular morbidity and mortality in COPD patients. Capillary rarefaction, an early event in COPD before vascular remodeling, is a potential mechanism of exercise-induced and resting arterial hypertension. Impaired training-induced capillarization was observed earlier in COPD patients; thus, this study compares the changes in blood pr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
11
1

Year Published

2019
2019
2024
2024

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 8 publications
(12 citation statements)
references
References 52 publications
(74 reference statements)
0
11
1
Order By: Relevance
“…Interestingly, during healthy aging there appears to be local feedback that coordinates capillary rarefaction in order to preserve appropriate supply to the individual fibre requirements [63]. However, there are a number of pathologies that are accompanied by impaired peripheral microvascular supply that may not maintain this relationship; including COPD [65], CHF [66][67][68], diabetes [30,35,48,69,70], PVD [44] and spinal cord injury (SCI) [71]. This supply-demand mismatch is an obvious candidate driving development of the observed exercise intolerance, and hence exercise-induced angiogenesis would appear to be a worthwhile therapeutic goal.…”
Section: Exercise-induced Angiogenesis In Diseasementioning
confidence: 99%
“…Interestingly, during healthy aging there appears to be local feedback that coordinates capillary rarefaction in order to preserve appropriate supply to the individual fibre requirements [63]. However, there are a number of pathologies that are accompanied by impaired peripheral microvascular supply that may not maintain this relationship; including COPD [65], CHF [66][67][68], diabetes [30,35,48,69,70], PVD [44] and spinal cord injury (SCI) [71]. This supply-demand mismatch is an obvious candidate driving development of the observed exercise intolerance, and hence exercise-induced angiogenesis would appear to be a worthwhile therapeutic goal.…”
Section: Exercise-induced Angiogenesis In Diseasementioning
confidence: 99%
“…“Angiogenesis” was observed to be significantly decreased among COPD patients versus controls. This suggested the possibility of blunted “angiogenesis” in COPD patients, who showed impaired training-induced blood pressure adaptation related to a change in muscle capillarizatio [ 34 , 35 ]. Hepatocyte growth factor was involved in the pathogenesis of various lung diseases as it was significantly higher in COPD patients compared to control patients.…”
Section: Resultsmentioning
confidence: 99%
“…The divergent functional response to different angiogenic stimuli highlights the potential pitfall in pharmacologically induced vascular expansion. Of course, such interpretation comes with the caveat that this experimental work used healthy, young animals; contrasting results may be found after pharmacological expansion of the capillary bed in muscle that exhibits a compromised microcirculation due to diseases like COPD, 44 heart failure 6 or spinal cord injury. 45 In this case, even stochastic vessel growth might prove beneficial in replacing otherwise lost capillaries.…”
Section: Discussionmentioning
confidence: 99%