Angiogenesis is a complex, highly coordinated process whereby an interplay between metabolic and mechanical stimuli promotes expansion of an existing microvascular network. 1 This process is an essential component of postnatal adaptive remodelling, providing the microvascular capacity to support adequate tissue oxygenation. Clinical observations and experimental approaches highlight the importance of maintaining a healthy microcirculation in skeletal muscle, where expansion of the capillary bed accompanies improved fatigue resistance, 2-4 while capillary rarefaction is associated with functional impairment. 4-10 Further, the distribution of capillaries within muscle has a significant bearing on the functional capacity, as