Impairment in Natural Killer Cells Editing of Immature Dendritic Cells by Infection with a Virulent &lt;b&gt;&lt;i&gt;Trypanosoma cruzi&lt;/i&gt;&lt;/b&gt; Population

Batalla, E; Martínez, Agustina M. Pino; Poncini, Carolina Verónica; Duffy, Tomás; Schijman, Alejandro G.; Cappa, S. M. González; Soto, Catalina Dirney Alba

doi:10.1159/000350242

Cited by 16 publications

(15 citation statements)

References 37 publications

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“…We and others have previously reported myeloid cell recruitment into the spleen of T. cruzi infected mice [8,25,32]. Here we found that along the acute infection myeloid Ly6C high and Ly6C + CD11c + cells were particularly recruited into secondary lymphoid organs (Figs.…”

Section: Traffic Of Ly6c + Mo and Enlarged Cd11c + Population In The supporting

confidence: 65%

Dual role of monocyte‐derived dendritic cells in Trypanosoma cruzi infection

Poncini

González-Cappa

2017

Eur J Immunol

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Pathogens can cause inflammation when inoculated into the skin. The vector-transmitted protozoan parasite Trypanosoma cruzi induces poor cellular-infiltration and disseminates, causing high mortality in the experimental model. Here, we characterized the inflammatory foci at the parasite inoculation site and secondary lymphoid organs using a murine model. While no macrophages and few neutrophils and monocytes (Mo) were recruited into the skin, T. cruzi infection elicited the mobilization of Ly6C Mo to draining lymph nodes and spleen. Over time, this population became enriched in CD11b Ly6C CD11c MHCII CD86 cells resembling inflammatory dendritic cells (DCs). Adoptive transfer of Ly6C Mo purified from the bone marrow of CD11c-GFP transgenic mice confirmed the monocytic origin of Ly6C DCs found in the spleen of infected animals. Isolated Mo-derived cells not only produced TNF-α and nitric oxide, but also IL-10 and displayed a poor capacity to induce lymphoproliferation. Ablation of Mo-derived cells by 5-fluorouracil confirmed their dual role during infection, limiting the parasite load by inducible nitric oxide synthase-related mechanisms and negatively affecting the development of anti-parasite T-cell response. This study demonstrated that consistent with their antagonistic properties, these cells not only control the parasite spreading but also its persistence in the host.

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Section: Traffic Of Ly6c + Mo and Enlarged Cd11c + Population In The supporting

confidence: 65%

Dual role of monocyte‐derived dendritic cells in Trypanosoma cruzi infection

Poncini

González-Cappa

2017

Eur J Immunol

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“…This mechanism depends on the NK cell activation by IL-12, and involves the exocytosis of cytotoxic granules, but is perforin-independent (65, 66), which led to the conclusion that the role of NK cells in controlling the parasite burden has more to do with direct extracellular parasite killing than with the elimination of T. cruzi infected cells.…”

Section: Innate Immunitymentioning

confidence: 99%

“…On that regards, murine model experiments have shown that live parasites, unlike their lysate, affect NK cells cytotoxicity on immature DCs, and that this effect causes greater parasitaemia and lower mice survival, without affecting parasite burden (66). …”

Section: Innate Immunitymentioning

confidence: 99%

The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease

2018

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Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune response in a very complex and flowery manner. The history of host-parasite co-evolution has provided this protozoan with means of resisting, escaping or subverting the mechanisms of immunity and establishing a chronic infection. Despite many decades of research on the subject, the infection remains incurable, and the factors that steer chronic Chagas disease from an asymptomatic state to clinical onset are still unclear. As the relationship between T. cruzi and the host immune system is intricate, so is the amount and diversity of scientific knowledge on the matter. Many of the mechanisms of immunity are fairly well understood, but unveiling the factors that lead each of these to success or failure, within the coordinated response as a whole, requires further research. The intention behind this Review is to compile the available information on the different aspects of the immune response, with an emphasis on those phenomena that have been studied and confirmed in the human host. For ease of comprehension, it has been subdivided in sections that cover the main humoral and cell-mediated components involved therein. However, we also intend to underline that these elements are not independent, but function intimately and concertedly. Here, we summarize years of investigation carried out to unravel the puzzling interplay between the host and the parasite.

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“…Broad differences in biological properties among T. cruzi isolates have been recognized (Buscaglia and Di Noia, 2003, Alba Soto et al, 2003, Batalla et al, 2013. The wealth of T. cruzi genotypes and phenotypes are actually grouped into six DTU TcI-TcVI (Zingales et al, 2009).…”

Section: Myoblasts Loosely Adherent or Non-adherent Cells)mentioning

confidence: 99%