Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients

Vavougios, George D.; Ntoskas, Konstantinos T.; Doskas, Triantafyllos

doi:10.1016/j.mehy.2020.110475

Cited by 8 publications

(12 citation statements)

References 59 publications

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“…Se levels are lower in patients with COVID-19 than in healthy subjects [ 99 , 100 ]. Furthermore, Se deficiency has been associated with the risk of COVID-19 complications and mortality, although the relationship between Se and COVID-19 severity is not definitively demonstrated [ 101 , 102 , 103 , 104 , 105 , 106 , 107 ]. Besides, an association between soil Se content and COVID-19 incidence was found in different cities in Hubei Province, as well as an association between soil Se content and the reported outcomes of COVID-19 cases in China [ 108 , 109 ].…”

Section: Other Pathophysiological Conditions Beyond Intake Potentially Affecting Se Levels and The Relationship With Thyroid Functionmentioning

confidence: 99%

Selenium: An Element of Life Essential for Thyroid Function

et al. 2021

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Selenium (Se), a microelement essential for life, is critical for homeostasis of several critical functions, such as those related to immune–endocrine function and signaling transduction pathways. In particular, Se is critical for the function of the thyroid, and it is particularly abundant in this gland. Unfortunately, Se deficiency is a very common condition worldwide. Supplementation is possible, but as Se has a narrow safety level, toxic levels are close to those normally required for a correct need. Thus, whether the obtaining of optimal selenium concentration is desirable, the risk of dangerous concentrations must be equally excluded. This review addressed the contribution by environment and food intake on Se circulating levels (e.g., geographical factors, such as soil concentration and climate, and different quantities in food, such as nuts, cereals, eggs, meat and fish) and effects related to its deficiency or excess, together with the role of selenium and selenoproteins in the thyroid pathophysiology (e.g., Hashimoto’s thyroiditis and Graves’ disease).

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Section: Other Pathophysiological Conditions Beyond Intake Potentially Affecting Se Levels and The Relationship With Thyroid Functionmentioning

confidence: 99%

Selenium: An Element of Life Essential for Thyroid Function

et al. 2021

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“…In summary, there is a mechanism proposed by [14] by which selenium might suppress the life cycle and mutation to virulence of SARS-COV-2 while attenuating viral-induced oxidative stress, organ damage and the cytokine storm. Adding these findings, a current question has been posed speculating whether the disturbances induced by SARS-CoV-2 in the homeostasis of selenium contribute to the manifestation of COVID-19 coagulopathy [150].…”

Section: Selenium Immune System and Covid-19mentioning

confidence: 99%

Nutritional risk of vitamin D, vitamin C, zinc, and selenium deficiency on risk and clinical outcomes of COVID-19: A narrative review

Pedrosa

Barros

Leite-Lais

2022

Clinical Nutrition ESPEN

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The pathogenicity of the current coronavirus disease shows postulates that optimal status of essential nutrients is crucial in supporting both the early viraemic and later hyperinflammatory phases of COVID-19. Micronutrients such as vitamin C, D, zinc, and selenium play roles in antioxidant, antiinflammatory, antithrombotic, antiviral, and immuno-modulatory functions and are useful in both innate and adaptive immunity. The purpose of this review is to provide a high-level summary of evidence on clinical outcomes associated with nutritional risk of these micronutrients observed in patients with COVID-19. A literature search was performed on PubMed and Google Scholar to obtain findings of crosssectional and experimental studies in humans. The search resulted in a total of 1212 reports including all nutrients, but only 85 were included according to the eligibility criteria. Despite the diversity of studies and the lack of randomized clinical trials and prospective cohorts, there is evidence of the potential protective and therapeutic roles of vitamin C, D, zinc, and selenium in COVID-19. The findings summarized in this review will contribute to guide interventions in clinical practice or in future clinical studies.

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“…Moreover, ACE2 can also be inhibited by Se in the form of selenoneine [109] . Sodium selenite has shown a protective function by inactivating the new coronavirus through the oxidation of thiol groups of the protein dissulfite isomerase and avoiding its penetration into healthy host cells [110] . Although the essential level of intake is very low, Se deficiency is prevalent in a large part of the population, especially in some European countries, sub-Saharan Africa, and several provinces in China [97] , [110] .…”

Section: Trace Elements Homeostasis and Viral Infectionmentioning

confidence: 99%

“…Sodium selenite has shown a protective function by inactivating the new coronavirus through the oxidation of thiol groups of the protein dissulfite isomerase and avoiding its penetration into healthy host cells [110] . Although the essential level of intake is very low, Se deficiency is prevalent in a large part of the population, especially in some European countries, sub-Saharan Africa, and several provinces in China [97] , [110] . Most studies have demonstrated that Se deficit leads to increase host-susceptibility to viral infections, as well as serious diseases and fatal outcomes, since a Se deficiency promotes the weakening of the antioxidant defense and immune response, favoring mutation, replication and increased in viral virulence [106] , [109] .…”

Section: Trace Elements Homeostasis and Viral Infectionmentioning

confidence: 99%