Impairment of dynamic thiol–disulphide homeostasis in patients with idiopathic Parkinson’s disease and its relationship with clinical stage of disease

Vural, Gönül; Gümüşyayla, Şadiye; Bektaş, Hesna; Denız, Orhan; Alışık, Murat; Erel, Özcan

doi:10.1016/j.clineuro.2016.12.009

Cited by 24 publications

(19 citation statements)

References 40 publications

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“…Furthermore, it has been demonstrated that lower NT levels were associated with higher infarct volume and higher National Institutes of Health Stroke Scale score [41][42][43] Headache including migraine and tension-type headache in childhood was investigated in a study. It has been established that there was no significant difference in patient group compared to control group in terms of TDH.…”

Section: Neurological Diseasesmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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Section: Neurological Diseasesmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…Loss of DA leads to symptoms such as resting tremor, rigidity, bradykinesia, sleep disorder, cognitive deficits, and depression (429). PD has been associated with decreased levels of GSH and other thiols, which are vital for the maintenance of redox balance (387,391,392,523). The generation and sources of ROS in PD include the metabolism of DA, mitochondrial dysfunction, iron deposition, inflammation, aberrant calcium handling, and aging.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities

Sbodio

Snyder

Paul

2019

Antioxidants & Redox Signaling

108

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Due to the importance of redox control in physiologic processes, organisms have evolved multiple pathways to counteract redox imbalance and maintain homeostasis. Cells and tissues address stress by harnessing an array of both endogenous and exogenous redox active substances. Targeting these pathways can help mitigate symptoms associated with neurodegeneration and may provide avenues for novel therapeutics. Antioxid. Redox Signal. 00, 000-000.

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“…Additionally, in that study, it was demonstrated that there was an increase in disulphide-to-native thiol and disulphide-to-total thiol ratios in patients with Parkinson's disease. 29 A previous study revealed that there were increased dynamic disulphide levels in with children with attention deficit and hyperactivity disorder. However, the difference was not statistically significant compared to the control group.…”

Section: Discussionmentioning

confidence: 97%

“…In those studies, levels of native and total thiols were found to be significantly low. 29,30 A study conducted by Vural et al 29 demonstrated that total thiol and native thiol levels were decreased in patients with Parkinson's disease compared to the control group. Additionally, in that study, it was demonstrated that there was an increase in disulphide-to-native thiol and disulphide-to-total thiol ratios in patients with Parkinson's disease.…”

Section: Discussionmentioning

confidence: 99%

Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder

Asoğlu¹,

Kılıçaslan²,

Beginoğlu³

et al. 2017

Anadolu Psikiyatri Derg

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Impairment of dynamic thiol–disulphide homeostasis in patients with idiopathic Parkinson’s disease and its relationship with clinical stage of disease

Cited by 24 publications

References 40 publications

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities

Thiol/disulphide homeostasis as a new oxidative stress marker in untreated patients with generalized anxiety disorder

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