1993
DOI: 10.1139/y93-046
|View full text |Cite
|
Sign up to set email alerts
|

Impairment of endothelium-dependent relaxation of superior mesenteric artery in genetically diabetic WBN/Kob rats

Abstract: The endothelium-dependent relaxation of superior mesenteric arteries of Wistar and genetically diabetic WBN/Kob rats was compared. Endothelium-dependent relaxation induced by acetylcholine (ACh) and A23187 was depressed in WBN/Kob rats. Relaxation induced by sodium nitroprusside, an endothelium-independent agent, in strips from WBN/Kob rats was similar to that in strips from Wistar rats. Indomethacin (5 x 10(-6) M) enhanced the relaxation responses to ACh in strips from both WBN/Kob and Wistar rats; however, e… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
3
0

Year Published

1996
1996
2016
2016

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 13 publications
(5 citation statements)
references
References 0 publications
2
3
0
Order By: Relevance
“…In two genetic models of IDDM, a similar impaired relaxation has been documented in the aorta [Durante et al, 1988;Pieper et al, 1996] and mesenteric arteries [Heygate et al, 1995;Lindsay et al, 1997] of diabetes-prone BB/W or BB/E rats. Similar results are reported for aorta and mesenteric arteries [Miyata et al, 1993] of the diabetes-prone WBN/Kob rat. Also, cGMP levels are low in aortas of diabetic rats, suggesting that basal concentrations of NO are reduced in these vessels.…”
Section: Microvascular Dysfunction In Type-1 Diabetes Mellitussupporting
confidence: 89%
“…In two genetic models of IDDM, a similar impaired relaxation has been documented in the aorta [Durante et al, 1988;Pieper et al, 1996] and mesenteric arteries [Heygate et al, 1995;Lindsay et al, 1997] of diabetes-prone BB/W or BB/E rats. Similar results are reported for aorta and mesenteric arteries [Miyata et al, 1993] of the diabetes-prone WBN/Kob rat. Also, cGMP levels are low in aortas of diabetic rats, suggesting that basal concentrations of NO are reduced in these vessels.…”
Section: Microvascular Dysfunction In Type-1 Diabetes Mellitussupporting
confidence: 89%
“…In two genetic models of IDDM, similar impaired relaxation has been documented in aorta [31][32][33] and mesenteric arteries 34,35 of diabetes-prone BB/Wor or BB/E rats and in aorta 36 and mesenteric arteries 37 of the diabetes-prone WBN/Kob rat. Almost without exception, studies that have shown impaired endothelium-dependent relaxation have found normal relaxation to nitrovasodilators.…”
Section: Impaired Endothelium-dependent Relaxation Experimental Diabesupporting
confidence: 53%
“…A reduction in the release of endothelium‐derived relaxing factor (EDRF) from the vascular endothelium or a decrease in endothelium‐dependent relaxation has been demonstrated in vascular tissues obtained from cholesterol‐fed rabbits and in human atherosclerotic coronary arteries (Freiman et al ., 1986; Habib et al ., 1986; Verbeuren et al ., 1986; Bossaller et al ., 1987; Jayakody et al ., 1987; Forsterman et al ., 1988; Shimokawa & Vanhoutte, 1989; Simon et al ., 1983). Impaired endothelium‐dependent relaxation has also been observed in the blood vessels of genetically diabetic rats (Durante et al ., 1988; Miyata et al ., 1992; 1993). STZ‐induced diabetic rats (Oyama et al ., 1986; Pieper & Gross, 1988; Kamata et al ., 1989a,b; 1992; Abiru et al ., 1993; Poston & Taylor, 1995) and alloxan‐induced diabetic rabbits (Tesfamariam et al ., 1989; Abiru et al ., 1990a,b; 1991).…”
Section: Discussionmentioning
confidence: 99%