Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A

Chattopadhyay, Matangini; Mukherjee, Sandip; Chatterjee, Subhendu Kumar; Chattopadhyay, Dipanjan; Das, Snehasis; Majumdar, Subeer S.; Mukhopadhyay, Satinath; Mukherjee, Sutapa; Bhattarcharya, Samir

doi:10.1016/j.cellsig.2017.10.005

Cited by 31 publications

(20 citation statements)

References 53 publications

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“…Fetuin-A is abundant, but its roles in disease progression are poorly understood. Previous studies reported that fetuin-A is crucial in lipid metabolism [22]. In this study, fetuin-A was not correlated with HDL-C or LDL-C, although HDL-C was nonsignificantly lower in persons with moderate/severe periodontitis.…”

Section: Discussioncontrasting

confidence: 53%

Association of low fetuin-A levels with periodontitis in community-dwelling adults

et al. 2020

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Fetuin-A is a liver-secreted glycoprotein isolated from fetal bovine serum. Recent reports of its several pathological functions suggest an association between fetuin-A and systemic diseases. This study therefore examined the correlation between serum fetuin-A level and periodontal status. Data from 356 middle-aged and elderly adults who underwent health examinations in Goto, Japan, during the period from 2008 through 2010 were analyzed. Systemic and periodontal measurements were recorded, and serum fetuin-A level was determined by using an enzyme-linked immunosorbent assay. Fetuin-A levels for participants with moderate to severe periodontitis were significantly lower than those for participants with no or mild periodontitis. Additionally, fetuin-A level negatively correlated with periodontal clinical attachment loss. Moderate to severe periodontitis was significantly correlated with low serum fetuin-A levels (odds ratio, 1.69; 95% confidence interval, 1.01-2.69) in logistic regression analysis. Low serum fetuin-A level was correlated with worse periodontal status and could thus potentially serve as a marker of periodontitis.

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Section: Discussioncontrasting

confidence: 53%

Association of low fetuin-A levels with periodontitis in community-dwelling adults

et al. 2020

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“…In particular, fetuin-A is the contributor which plays a critical role in the impairment of two metabolic sensors, Sirtuin 1 and AMP-activated protein kinase, in inflamed adipocytes of high fat diet mice [20]. Several studies was proposed that increased circulating fetuin-A in humans after a chronic exercise program may promote increased weight loss and improved metabolic control through elevation of adiponectin expression [20] and decrease of inflammatory cytokines in the liver and muscle [21] via fetuin-A inhibition through the AMP-activated protein kinase-nuclear factor kappa-light-chain-enhancer of activated B cells pathway [4]. Furthermore, fetuin-A directly correlated with two cardiometabolic risk markers, Apo B and C-reactive protein that, together with insulin resistance, are important components of the metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: a systematic review and Meta-analysis

et al. 2019

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BackgroundElevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver disease. This meta-analysis investigated whether exercise interventions can reduce fetuin-A in adults.MethodsWe searched clinical trials that objectively assessed fetuin-A and included study arms with exercise intervention. The pre-intervention and post-intervention data were used for meta-analysis. The effect sizes were calculated as standardized mean differences or changes in fetuin-A and expressed as Hedges’ g using random-effects models.ResultsThe overall Hedges’ g for fetuin-A in all included interventions was − 0.640 (95%CI − 1.129 to − 0.151; n = 9), but this effect was not observed in obese (g = − 0.096; 95%CI, − 0.328 to 0.135) and type 2 diabetes/dysglycemia (g = − 0.56; 95%CI, − 1.348 to 0.236) individuals. Additionally, the random-effects meta-regression analysis showed that there was not a greater decrease in fetuin-A in individuals who achieved greater body mass index reductions (regression coefficient = 0.065; 95%CI, − 0.185 to 0.315).ConclusionSupervised exercise is associated with reductions in fetuin-A levels in adults and elderly. However, the results of the present meta-analysis should be interpreted with caution because of the variety of type of exercises and individual obesity related-disorders involve. Therefore, additional high-quality randomized controlled trials describing the effect of supervised exercise interventions on fetuin-A in adults are still needed. Electronic supplementary materialThe online version of this article (10.1186/s12944-019-0962-2) contains supplementary material, which is available to authorized users.

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“…On the other hand, the role of FetA in the pathogenesis of inflammation, both in the systemic and tissue-specific inflammation, has received substantial attention in recent years. As described previously, FetA could induce the synthesis and secretion of pro-inflammatory adipokines and synergistically inhibit the lipid efflux especially within macrophages [117, 118]. In addition, the adipocyte-derived FetA shows the effect on the transformation of the anti-inflammatory M2-phenotype macrophages into the pro-inflammatory M1-phenotype macrophages, thus promoting the inflammatory process in humans [116].…”

Section: Adipokines Are Pathogenic Factors Which Link Psoriasis and Omentioning

confidence: 87%

New insights into different adipokines in linking the pathophysiology of obesity and psoriasis

Kong

Zhang

et al. 2019

Lipids Health Dis

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Psoriasis is a chronic, systemic, hyper-proliferative immune-mediated inflammatory skin disease. The results of epidemiological investigations have shown that psoriasis affects around 2% of the general population worldwide, and the total number of psoriasis patients is more than 6 million in China. Apart from the skin manifestations, psoriasis has been verified to associate with several metabolic comorbidities, such as insulin resistance, diabetes and obesity. However, the underlying mechanism is still not elucidated. Adipocytes, considered as the active endocrine cells, are dysfunctional in obesity which displays increased synthesis and secretion of adipokines with other modified metabolic properties. Currently, growing evidence has pointed to the central role of adipokines in adipose tissue and the immune system, providing new insights into the effect of adipokines in linking the pathophysiology of obesity and psoriasis. In this review, we summarize the current understanding of the pathological role of adipokines and the potential mechanisms whereby different adipokines link obesity and psoriasis. Furthermore, we also provide evidence which identifies a potential therapeutic target aiming at adipokines for the management of these two diseases.

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Impairment of energy sensors, SIRT1 and AMPK, in lipid induced inflamed adipocyte is regulated by Fetuin A

Cited by 31 publications

References 53 publications

Association of low fetuin-A levels with periodontitis in community-dwelling adults

Association of low fetuin-A levels with periodontitis in community-dwelling adults

Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: a systematic review and Meta-analysis

New insights into different adipokines in linking the pathophysiology of obesity and psoriasis

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