Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats

Adedara, Isaac A.; Abolaji, Amos O.; Odion, Blessing E.; Okwudi, Isioma J.; Omoloja, Abiola A.

doi:10.1155/2014/239240

Cited by 20 publications

(28 citation statements)

References 33 publications

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“…Exposure of rats to fluoride at 15 mg/L of drinking water for 45 consecutive days significantly decreased the absolute weight and organo-somatic index of the kidney in the treated rats, thus indicating an overt renal toxicity in the rats. The organo-somatic index is an important index of swelling, atrophy, or hypertrophy [32]. The decrease in the kidney of fluoride-exposed rats in the present study indicates atrophy which may be due to a direct effect of fluoride on the kidney.…”

Section: Discussionmentioning

confidence: 42%

Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride

Adedara

Ojuade

Olabiyi

et al. 2016

Biol Trace Elem Res

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Excessive exposure to fluoride poses several detrimental effects to human health particularly the kidney which is a major organ involved in its elimination from the body. The influence of taurine on fluoride-induced renal toxicity was investigated in a co-exposure paradigm for 45 days using five groups of eight rats each. Group I rats received normal drinking water alone, group II rats were exposed to sodium fluoride (NaF) in drinking water at 15 mg/L alone, group III received taurine alone at a dose of 200 mg/kg group IV rats were co-administered with NaF and taurine (100 mg/kg), while group V rats were co-administered with NaF and taurine (200 mg/kg). Administration of taurine significantly reversed the fluoride-mediated decrease in absolute weight and organo-somatic index of the kidney in the exposed rats. Taurine significantly prevented fluoride-induced elevation in plasma urea and creatinine levels in the exposed rats. Moreover, taurine restored fluoride-mediated decrease in the circulatory concentrations of triiodothyronine, thyroxine, and the ratio of triiodothyronine to thyroxine. Taurine ameliorated fluoride-mediated decrease in renal antioxidant status by significantly enhancing the antioxidant enzyme activities as well as glutathione level in the exposed rats. Additionally, taurine inhibited fluoride-induced renal oxidative damage by markedly decreasing the hydrogen peroxide and malondialdehyde levels as well as improved the kidney architecture in the treated rats. Collectively, taurine protected against fluoride-induced renal toxicity via enhancement of thyroid gland function, renal antioxidant status, and histology in rats.

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Section: Discussionmentioning

confidence: 42%

Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride

Adedara

Ojuade

Olabiyi

et al. 2016

Biol Trace Elem Res

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“…It might be due to the formation of highly reactive radicals and subsequent lipid peroxidation induced by BE. 22,32 In conclusion, significant sero-clinical and pathological observations were associated with the sub-acute exposure of BE to rats especially at the doses of 5 mg/ kg and 3 mg/kg. Extrapolation of research findings from the laboratory to the bedside involves variables such as age, season, diet, general health, contaminant interaction, and interspecies differences in metabolism, but there exists the possibility that indigenous human population could be sensitive to BE.…”

Section: Bementioning

confidence: 88%

Alterations in morphology and hepatorenal indices in rats subacutely exposed to bitumen extract

et al. 2016

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Bitumen is a complex mixture of dense and extremely viscous organic liquids produced by distillation of crude oil during petroleum refining. Nigeria has a large deposit of natural bitumen, yet to be fully exploited. Discharges of petroleum hydrocarbons and other petroleum-derived products have caused environmental pollution and adverse human health effects in several oil-rich communities. In this study, bitumen obtained from a seepage source in Agbabu, the town of first discovery, was used in sub-acute toxicity studies in a rat experimental model, in order to assess potential health risks posed to local populace sequel to full exploitation of bitumen. Dosages were chosen to accommodate low to high cases of environmental exposures. Male Wistar rats were administered, per os, dosages of bitumen extract at 5, 3, 2, and 1 mg/kg body weight. Following euthanasia 28 days later, histological findings revealed severe portal congestion and cellular infiltration in the liver, while in the kidney there were protein casts in the tubular lumen. The relative liver and kidney weights in the 5 mg/kg groups were 34% and 40% higher than in the controls, with a concomitant decrease in food and water consumption. Furthermore, plasma clinical analyses revealed marked elevation in aspartate aminotransferase and triglycerides levels in bitumen extract-intoxicated rats. The results indicate the potential hepatorenal toxicity in adult rats following repeated exposure to bitumen extract. ARTICLE HISTORY

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“…Clinical surveys and animal model experiments have revealed that raised levels of ALT and AST activities are indicative of organ damage, specifically, in pathologic and toxicologic events leading to cardiac and hepatic necrosis [29,[42][43][44] . Precisely, earlier studies had associated raised serum ALT activity with non-diabetic non-alcoholic fatty liver disease and insulin resistance [45][46][47][48][49][50] .…”

Section: Discussionmentioning

confidence: 99%

“…The hepatic tissues play a central role in the biotransformation of xenobiotics and endogenous molecules prior to their elimination from the body [26][27][28] . The biotransformation of xenobiotics in the hepatocytes may elicit the formation of noxious and highly reactive compounds or potentially toxic metabolites, which in the process of their metabolism predisposes the hepatocytes to injuries and dysfunction [29] . The renal tissues are highly specialized in ensuring delicate balance in selective excretion or retention of body biomolecules, according to their physiologic renal threshold indices [30] .…”

Section: Introductionmentioning

confidence: 99%

Pathological research on acute hepatic and renal tissue damage in Wistar rats induced by cocoa

Ibegbulem

Chikezie

Dike

2016

Journal of Acute Disease

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A B S T R A C TObjective: To ascertain the functional integrity of renal and hepatic tissues of Wistar rats fed with processed cocoa bean-based beverages and raw cocoa bean products-containing diets by using biochemical and histological methods. Methods: Thirty Wistar rats were designated on the basis of experimental diets which were given for 28 days. At the end of the feeding period, blood samples were drawn, and renal and hepatic tissues were excised from the experimental rat groups for functional tests and histological examinations, respectively. Results: Serum alanine aminotransferase activities of the experimental rat groups showed no significant difference (P > 0.05) and were within a relatively narrow range of (32.17 ± 4.98) IU/L to (41.00 ± 10.85) IU/L, whereas serum aspartate aminotransferase activities gave wide variation within the range of (15.67 ± 2.13) IU/L to (34.83 ± 8.31) IU/L with P < 0.05. Serum bilirubin concentrations of experimental rat groups were less than 1 mg/dL. Serum total protein and albumin concentrations varied within a relatively narrow range. Serum creatinine concentration was significantly lower (P < 0.05) than serum urea concentration. Histology showed evidence of moderate disarrangement of hepatic tissue architecture and degenerated tubules as well as glomerular turfs. Conclusions: The pattern of alanine aminotransferase activity being more active than aspartate aminotransferase one in serum appeared to correlate with the extent of disarrangement of hepatic tissue architecture. The experimental rat groups exhibited no hyperbilirubinemia. Also, diets containing processed cocoa bean and raw cocoa bean products did not substantially interfere with the capacity of the hepatocytes to biosynthesize plasma proteins and the functionality of renal tissues.

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Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats

Cited by 20 publications

References 33 publications

Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride

Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride

Alterations in morphology and hepatorenal indices in rats subacutely exposed to bitumen extract

Pathological research on acute hepatic and renal tissue damage in Wistar rats induced by cocoa

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