Impairment of male reproductive function after sleep deprivation

Alvarenga, Tathiana A.; Hirotsu, Camila; Mazaro-Costa, Renata; Tufik, Sérgio; Andersen, Mônica Levy

doi:10.1016/j.fertnstert.2015.02.002

Cited by 74 publications

(81 citation statements)

References 40 publications

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“…In addition, the period gene controls the duration of courtship song and mating time . The same impact on sexual maturation has been observed in rodents mutated for clock genes or subjected to circadian disruption . In humans, conditions of circadian disruption like shift work also impact sexual health and fertility .…”

Section: The Circadian Clock and Its Effect On Sexual Development Andmentioning

confidence: 86%

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

2019

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Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 diabetes, or neurological disorders. However, it is unclear to what extent a perturbation of pathways regulated by both the circadian clock and microbiota is involved in the development of these disorders. It is speculated that these perturbations are associated with impaired growth hormone (GH) secretion and sexual development. The GH axis is a broadly neglected pathway and could be the main converging point for the interaction of both circadian clock and microbiota. Here, the links between the circadian clock and microbiota are reviewed. Finally, the effects of chronodisruption and dysbiosis on physiology and pathology are discussed and it is speculated whether a common deregulation of the GH pathway could mediates those effects.

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Section: The Circadian Clock and Its Effect On Sexual Development Andmentioning

confidence: 86%

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

2019

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“…Previous reports have shown that acute sleep loss decreases plasma testosterone concentration (Alvarenga, Andersen, Velázquez‐Moctezuma, & Tufik, ; Alvarenga, Hirotsu, Mazaro‐Costa, Tufik, & Andersen, ; Andersen, Bignotto, Machado, & Tufik, ; Andersen, Martins, D'Almeida, Bignotto, & Tufik, ; Wu et al., ); a progressive reduction in plasma testosterone has been observed in male rats along 4 days of sleep loss with a 57% decrease in the first day and a 88% decrease in the 4th day (Andersen et al., ). Interestingly, plasma testosterone levels did not return to basal levels despite sleep recovery periods of 96 hr after 4 days of sleep deprivation (Andersen et al., ).…”

Section: Introductionmentioning

confidence: 91%

“…Interestingly, plasma testosterone levels did not return to basal levels despite sleep recovery periods of 96 hr after 4 days of sleep deprivation (Andersen et al., ). In addition, acute sleep loss increases Hsd11b1 mRNA expression in the testis (Alvarenga et al., ), resulting in reduced testosterone local effects at the blood–testis barrier. The reduced testosterone levels, both systemic and local, may impact male fertility by altering the androgen‐dependent steps during spermatogenesis, spermiation (Smith & Walker, ) and sperm maturation (Foldesy & Bedford, ).…”

Section: Introductionmentioning

confidence: 99%

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Chronic sleep loss disrupts blood–testis and blood–epididymis barriers, and reduces male fertility

Domı́nguez-Salazar

Hurtado‐Alvarado

Medina-Flores

et al. 2019

Journal of Sleep Research

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Sleep loss increases blood-brain barrier permeability. As the blood-brain barrier and the blood-tissue barriers in the reproductive tract (blood-testis and bloodepididymis barriers) share common characteristics, we hypothesized that sleep restriction may also modify their barrier function. Previous reports showed that sleep loss decreased sperm viability and progressive fast mobility, which may be a consequence of altered blood-testis and blood-epididymis barrier. Therefore, we quantified changes in blood-testis and blood-epididymis barrier after sleep loss and related them to male fertility. Adult male Wistar rats were sleep restricted using the multiple-platform technique in a protocol of 20 hr daily sleep deprivation plus 4 hr of sleep recovery in the home-cage. At the 10th day, barrier permeability assays were performed with Na-fluorescein, 10 kDa Cascade blue-dextrans and Evans blue, and the expression of tight junction proteins, actin and androgen receptor was quantified. At the 10th day of sleep restriction and after sleep recovery days 1-7, males were placed with sexually receptive females, sexual behaviour was tested, and the percentage of pregnancies was calculated. Sleep restriction increased the barrier permeability to low-and high-molecular-weight tracers, and decreased the expression of tight junction proteins, actin and androgen receptor. Concomitantly, sleep restriction reduced the percentage of ejaculating males and the number of pregnancies. Sleep recovery for 2-3 days progressively re-established fertility, as indicated by a higher percentage of ejaculating males and impregnated females. In conclusion, chronic sleep loss alters fertility concomitantly with the disruption of the blood-tissue barriers at the reproductive tract, the mechanism involves androgen signalling. K E Y W O R D S 10 kDa Cascade blue-dextrans, androgen receptor, blood-testis barrier, claudin 11, Evans blue, male fertility, male sexual behaviour, Na-fluorescein, occludin, sleep restriction S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Domínguez-Salazar E, Hurtado-Alvarado G, Medina-Flores F, et al. Chronic sleep loss disrupts blood-testis and blood-epididymis barriers, and reduces male fertility. J Sleep Res. 2020;29:e12907. https ://doi.

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“…Hence, sleep disruption may be associated with hormonal imbalance. In a study on male rodents, sleep deprivation led to lower testosterone levels and worse sperm viabilities than in controls [32]. Jauch-Chara et al .…”

Section: Obstructive Sleep Apnea and Gonadsmentioning

confidence: 99%

Obstructive sleep apnea and hormones – a novel insight

Ruchała

Bromińska

Cyrańska-Chyrek

et al. 2017

aoms

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Obstructive sleep apnea (OSA), a disorder characterized by repetitive collapse of the upper respiratory tract during sleep, occurs in about 4% of middle-aged men and 2% of women. The incidence of the disorder is rising due to an increase in obesity and ageing of the population. Patients with obstructive sleep apnea are at elevated risk of some endocrinal and metabolic disorders, which may lead to serious consequences including shortening of life expectancy. The recognition and understanding of interactions between local upper airway dysfunction and its endocrinal consequences is therefore vital. In this review we will focus on the influence of OSA on bone metabolism and endocrine homeostasis.

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Impairment of male reproductive function after sleep deprivation

Cited by 74 publications

References 40 publications

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

Chronic sleep loss disrupts blood–testis and blood–epididymis barriers, and reduces male fertility

Obstructive sleep apnea and hormones – a novel insight

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