Impairment of primary expulsion of <i>Trichuris muris</i> in mice concurrently infected with <i>Nematospiroides dubius</i>

Jenkins, Simon N; Behnke, Jerzy M.

doi:10.1017/s0031182000048332

Cited by 115 publications

(73 citation statements)

References 11 publications

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“…The strain of H. bakeri used was obtained from Professor Jerzy Behnke (University of Nottingham, UK), and maintained in our laboratory through passages in C57BL/6 mice (see Jenkins and Behnke, 1977 for full origin details). The parasite corresponds to H. polygyrus bakeri reported by Durett-Desset et al (1972).…”

Section: Infection Protocol and Experimental Designmentioning

confidence: 99%

Interactive effects of protein nutrition, genetic growth potential andHeligmosomoides bakeriinfection pressure on resilience and resistance in mice

Coltherd

Babayan

Bünger³

et al. 2011

Parasitology

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SUMMARYThe ability of animals to cope with an increasing parasite load, in terms of resilience and resistance, may be affected by both nutrient supply and demand. Here, we hypothesized that host nutrition and growth potential interact and influence the ability of mice to cope with different parasite doses. Mice selected for high (ROH) or low (ROL) body weight were fed a low (40 g/kg; LP) or high (230 g/kg; HP) protein diet and infected with 0, 50, 100, 150, 200 or 250 L3infectiveHeligmosomoides bakerilarvae. ROH-LP mice grew less at doses of 150 L3and above, whilst growth of ROH-HP and of ROL mice was not affected by infection pressure. Total worm burdens reached a plateau at doses of 150L3, whilst ROH mice excreted fewer worm eggs than ROL mice. Serum antibodies increased with infection dose and ROH mice were found to have higher parasite-specific IgG1 titres than ROL mice. In contrast, ROL had higher total IgE titres than ROH mice, only on HP diets. The interaction between host nutrition and growth potential appears to differentially affect resilience and resistance in mice. However, the results support the view that parasitism penalises performance in animals selected for higher growth.

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Section: Infection Protocol and Experimental Designmentioning

confidence: 99%

Interactive effects of protein nutrition, genetic growth potential andHeligmosomoides bakeriinfection pressure on resilience and resistance in mice

Coltherd

Babayan

Bünger³

et al. 2011

Parasitology

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“…The methods used for maintenance and infection of mice and recovery of adult worms at autopsy were essentially as described by Jenkins & Behnke (1977).…”

Section: Heligmosomoides Polygyrusmentioning

confidence: 99%

The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype

2003

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T helper cell (Th1 and Th2) associated responses were examined following a primary infection with the gastrointestinal nematode Heligmosomoides polygyrus in five inbred strains of mice with different resistance phenotypes. Levels of (i) mast cell protease, (ii) specific IgE, (iii) nitric oxide and (iv) specific IgG2a, as markers of Th2 and Th1 associated responses, respectively, were determined in sera and intestinal fluids and correlated with worm burdens. The 'fast' responder (resistant) strains SWR and SJL produced strong Th2 and Th1 associated responses respectively in a mutually exclusive fashion. The F 1 hybrid (SWR £ SJL) F 1 , showed rapid expulsion of the parasite and expressed both intense Th1 and Th2 responses, suggesting synergism between Th1 and Th2 activity in these mice. The results indicate that both Th2 and Th1 responses operate in mice following a primary infection with H. polygyrus and that each Th response may be involved to a greater or lesser degree within certain strains. Resistance to H. polygyrus was found to correlate only to the intensity of either the gut-associated mastocytosis or nitric oxide production in these strains but not to either specific IgE or IgG2a titres. Chronic infections in the 'slow' response phenotype mouse strains CBA and C57BL/10, were associated with both poor Th2 and poor Th1-associated responses attributed to a general parasite-mediated immunosuppression of the host immune response to infection.

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“…Originally IL-4 was considered to be necessary for lgGl responses but the recent demonstration that in vivo depletion of 1L-4 abrogated IgE responses but did not and recovery of worms at autopsy have all been described previously (Jenkins & Behnke 1977).…”

Section: Parasite 1987) On the Other Hand H Pol%yrus Elicits Promimentioning

confidence: 99%

Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): parasite specific IgG1 antibody responses and primary response phenotype

Wahid

Behnke

1993

Parasite Immunology

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Impairment of primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius

Cited by 115 publications

References 11 publications

Interactive effects of protein nutrition, genetic growth potential andHeligmosomoides bakeriinfection pressure on resilience and resistance in mice

Interactive effects of protein nutrition, genetic growth potential andHeligmosomoides bakeriinfection pressure on resilience and resistance in mice

The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype

Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): parasite specific IgG1 antibody responses and primary response phenotype

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