Impairment of the phosphotransfer network and performance in broiler chickens experimentally infected by Eimeria spp.: The role of the oxidative stress

Fortuoso, Bruno F.; Baldissera, Matheus D.; Souza, Carine F.; Griss, Luiz Gustavo; Casagrande, Renata Assis; Cristo, Thierry Grima de; Santiani, Fábio; Cunha, Marily G. da; Boiago, Marcel Manente; Stefani, Lenita M.; Silva, Aleksandro S. Da

doi:10.1016/j.parint.2019.01.004

Cited by 10 publications

(5 citation statements)

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“…According to literature (Fortuoso et al, 2019;Galli et al, 2019;Griss et al, 2019;Khatlab et al, 2019;Muraina et al 2020) we found that the expression of MDA in renal coccidiosis of geese increased significantly in different life forms of the parasite. We interpreted this increase in MDA expression as lipid peroxidation-based oxidative stress may play an important role in the pathogenesis of the disease.…”

Section: Discussionmentioning

confidence: 84%

“…In our study, in addition to these clinical symptoms, we identified different clinical symptoms such as respiratory distress, tremor, inability to get up, balance disorders, rotational movement around their axis, and wheezing. We thought that this diversity observed in clinical symptoms may be related to the fact that parasitic factors weaken the immune system and predispose to the formation of other diseases (Liu et al, 2018;Fortuoso et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that coccidiosis in animals causes an increase in ROS and reactive nitrogen species (RNS), causes changes in antioxidant enzyme activities and a decrease in the concentrations of antioxidants (Khatlab et al, 2019). Fortuoso et al, (2019) found that serum ROS levels and lipid peroxidation increased in broiler chickens experimentally infected with Eimeria. In another study, an increase in intestinal ROS production with lipid peroxidation has been reported in chicks experimentally infected with Eimeria species (Galli et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Coccidiosis is a serious protozoan disease that causes hemorrhagic diarrhea, depression, weakening, wing drooping, sensitivity to other diseases and loss of body weight, as well as deaths, especially in young animals, caused by various Eimeria species (Sarı and Çakmak, 2008;Liu et al, 2018;Fortuoso et al, 2019). Coccidiosis, which is common in many parts of the world, causes serious problems in many animal species such as cattle, sheep, goats, dogs, cats, pigs and rabbits, especially in poultry (Dumanlı and Aktaş, 2015;Song et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Investigation of Lipid Peroxidation in Renal Coccidiosis of Geese

Yıldız¹,

Karakurt²

2021

Turkish Journal of Veterinary Research

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Objective: In this study, we aimed to evaluate the oxidative damage caused by lipid peroxidation due to renal coccidiosis by histopathological and immunohistochemical methods.Material-Method: The material of this study was made up of tissue samples taken from 139 geese whose average age was 10 weeks, who were brought to our department dead between 2013-2020. Tissue samples taken were fixed in 10% buffered formaldehyde solution. 5 µm-thick sections were taken from the paraffin blocks prepared after routine tissue follow-up procedures. Hematoxylin & Eosin staining was applied to the sections in order to detect histopathological changes. Sections were examined and photographed under a light microscope. Results: Various clinical signs such as fever, respiratory distress, weakness, anorexia, tremors, inability to get up from the ground, balance disorders, rotational movement, diarrhea, wheezing were detected in geese. In systemic necropsies of geese, large and small white nodular structures were detected in the kidney. In histopathological examinations, coccidiosis agents (E. truncata) were found in the tubular epithelium of the kidney. Necrosis and mononuclear cell infiltration were observed in the tubules due to the presence of E. truncata. In addition, edema and hyperemia in the lungs, multifocal necrosis in the liver, cell infiltration in the portal spaces, and enteritis were other important histopathological findings. In one case, aspergillosis was detected together with renal coccidiosis. We observed that MDA expression was more severe in the oocyst stages, which is the mature form of the parasite, compared to other parasitic life stages. Conclusion: Based on the results obtained from this study, it was revealed that renal coccidiosis in geese caused lipid peroxidation / oxidative damage through the increase in MDA expression.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Investigation of Lipid Peroxidation in Renal Coccidiosis of Geese

Yıldız¹,

Karakurt²

2021

Turkish Journal of Veterinary Research

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“…Coccidiosis is associated with oxidative stress caused by free radicals released by damaged tissue during coccidial infection (Fortuoso et al, 2019). E. tenella has been shown to impair broiler chicken's antioxidant status during infection (Georgieva et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Haematological Profile and Oxidative Stress Indices of Broiler Chickens Infected with Eimeria tenella and Treated with the Methanolic Extract of Vernonia amygdalina Leaf and Its Fractions

Biallah¹,

Lawal²,

Abdu³

et al. 2022

ijird

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Eimeria tenella infection in broiler chickens is associated with haemorrhagic typhlitis and anemia. The study aimed to evaluate the haematological parameters and oxidative stress profile of caecal coccidiosis in broiler chickens infected with E. tenella following the administration of the methanolic leaf extract of Vernonia amygdalina and its fractions. To evaluate the parameters, 210 broiler chickens were divided into seven groups with two replicates (n=15). The experimental groups were negative control (NC), positive control (PC), standard amprolium control (SC), crude methanol extract (ME), hexane fraction (HF), butanol fraction (BF), and aqueous residue fraction (AF). All birds were infected with 105 sporulated oocysts of E. tenella except those in the NC group and treated accordingly. The haematological parameters and oxidative stress markers were assessed at 7 and 14 days post-infection as evaluation criteria for the evaluation of the anticoccidial efficacy of treatments. The packed cell volume (PCV) of the NC group showed a significant decrease at 7 days post-infection but markedly improved at 14 days post-infection. There was a non-significant difference in the antioxidant values of the birds in all groups (p > 0.05), as no definite trend in the value measured parameters were recorded. It was concluded that treating infected birds with V. amygdalina effectively decreased blood loss and improved oxidative defence during caecal coccidiosis.

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Saprolegnia parasitica impairs branchial phosphoryl transfer network in naturally infected grass carp (Ctenopharyngodon idella): prejudice on bioenergetic homeostasis

et al. 2019

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Impairment of the phosphotransfer network and performance in broiler chickens experimentally infected by Eimeria spp.: The role of the oxidative stress

Cited by 10 publications

References 28 publications

Immunohistochemical Investigation of Lipid Peroxidation in Renal Coccidiosis of Geese

Immunohistochemical Investigation of Lipid Peroxidation in Renal Coccidiosis of Geese

Haematological Profile and Oxidative Stress Indices of Broiler Chickens Infected with Eimeria tenella and Treated with the Methanolic Extract of Vernonia amygdalina Leaf and Its Fractions

Saprolegnia parasitica impairs branchial phosphoryl transfer network in naturally infected grass carp (Ctenopharyngodon idella): prejudice on bioenergetic homeostasis

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