Impairment of Urate Excretion in Patients With Cardiac Disease

Mace, Sharon E.; Newman, Arthur J.; Liebman, Jerome

doi:10.1001/archpedi.1984.02140490067017

Cited by 11 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12,16 In our study, urinary uric acid excretions were also lower in the cyanotic patients than in the acyanotic patients, although these differences did not reach statistical significance. Enhanced urate reabsorption appears to result from renal hypoperfusion reinforced by high filtration fraction.…”

Section: Time Groupscontrasting

confidence: 66%

The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

Akıncı

Kanbak

et al. 2011

Renal Failure

View full text Add to dashboard Cite

Background: There are few data on the effects of anesthesia and cardiopulmonary bypass (CPB) on perioperative renal function in children with cyanotic congenital heart disease undergoing open heart surgery. This study aims to investigate the perioperative renal function in cyanotic versus acyanotic children undergoing sevoflurane anesthesia for open heart surgery. Methods: After receiving ethical committee approval, 12 acyanotic patients (preoperative oxygen saturation: SaO 2 > 85%) and 12 cyanotic children (SaO 2 < 85%) were included. Sevoflurane was administered at concentration levels of 2% before CPB and 1-2% during CPB after standard anesthesia induction. Inorganic fluoride, electrolytes, creatinine, urea nitrogen in serum and urine samples, and N-acetyl-β-D-glucosaminidase (NAG) in urine samples were measured before induction, before CPB, during CPB, after CPB, at the end of surgery, and at 24th h postoperatively. Results: The levels of serum uric acid levels were higher in the cyanotic group (p < 0.05). There were no differences in the levels of serum creatinine and urine creatinine, urea nitrogen, and electrolytes between the two groups. Serum inorganic fluoride levels were always higher in the acyanotic group than in the cyanotic group, but these differences between the groups reached statistical significance at two measurement times (before CPB and end of surgery) (p < 0.05). Urinary inorganic fluoride levels increased with time in both groups. Although urinary NAG increased significantly after the CPB in the cyanotic group, the differences between the two groups did not reach statistical significance. Conclusions: We have concluded that renal function was not affected during open heart surgery with sevoflurane anesthesia, in both cyanotic and acyanotic children.

show abstract

Section: Time Groupscontrasting

confidence: 66%

The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

Akıncı

Kanbak

et al. 2011

Renal Failure

View full text Add to dashboard Cite

show abstract

“…Hyperuricemia has been recently reported in patients with ischemic heart disease. 6,7 Uric acid (UA) can be released from ischemic tissues, 8,9 including the heart, during angi-na, 8,10,11 and hyperuricemia has been suggested as a risk factor for the development of atherothrombotic diseases. 12 A possible explanation for this relates to the inhibition of adenosine diphosphate degradation by UA and the subsequent stabilization of platelet aggregates.…”

mentioning

confidence: 99%

Hyperuricemia in Severe Pulmonary Hypertension

Voelkel

Wynne

Badesch

et al. 2000

Chest

114

View full text Add to dashboard Cite

“…One small study [15] detected an impairment in urinary excretion of uric acid in children with low cardiac output. Our findings suggest that the hyperuricemia may be caused, in part, by a reduction in urinary excretion of uric acid.…”

Section: Discussionmentioning

confidence: 99%

Uric acid renal excretion and renal insufficiency in decompensated severe heart failure

Ochiai

Barretto

Oliveira

et al. 2005

European J of Heart Fail

View full text Add to dashboard Cite

Objective: To evaluate uric acid renal excretion, hyperuricemia, renal dysfunction, and prognosis in patients with decompensated severe heart failure, as there are few data available. Methods: One hundred and twenty-two patients, hospitalized for heart failure decompensation, in NYHA class IV, were classified into 3 groups as follows. Pilot group [ejection fraction (EF)V0.45, n=16], group 1 (EFV0.45, n=90), and group 2 (EFN0.45 and valvular dysfunction, n=16). The patients in groups 1 and 2 underwent assessment of creatinine and uric acid clearance before and after pyrazinamide, to estimate uric acid tubular secretion. Uric acid clearance b6.8 mL/min and secretion b170 Ag/min were considered reduced. In groups 1 and pilot (n=106), mortality was analyzed by Cox regression model, and the prognostic value of hyperuricemia was assessed by ROC curve. Results: In groups 1 and 2, respectively, serum uric acid was 511.7 and 422.5 Amol/L, and creatinine clearance was 46.7 and 61.4 mL/min. Uric acid clearance (3.2 vs. 3.9 mL/min) and tubular secretion (116 vs. 128 Ag/min) were not different, but lower than normal values. In groups 1 and pilot, the 12-month mortality was 46.4% (CI 95%: 36.7%-56.0%). At end of follow-up, mortality was associated with impaired creatinine clearance ( pb0.001), but not with hyperuricemia ( p=0.236). Conclusions: In patients with decompensated severe heart failure, the tubular secretion and the clearance of uric acid were reduced. Renal dysfunction was associated with mortality, but hyperuricemia was not.

show abstract

Impairment of Urate Excretion in Patients With Cardiac Disease

Cited by 11 publications

References 34 publications

The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

Hyperuricemia in Severe Pulmonary Hypertension

Uric acid renal excretion and renal insufficiency in decompensated severe heart failure

Contact Info

Product

Resources

About