2023
DOI: 10.1002/admt.202201642
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Imparting Multi‐Scalar Architectural Control into Silk Materials Using a Simple Multi‐Functional Ice‐Templating Fabrication Platform

Abstract: Human tissues and organs exhibit complex hierarchical and gradient structures that are essential to their function and should be recapitulated within biomaterial scaffolds targeting their regeneration. Unidirectional freezing, an ice templating technique where ice acts as a porogen, is uniquely suited to recapitulating the architectural anisotropy, gradients, and hierarchical transitions of human tissues, but ice templating of polymeric systems, including silk fibroin, remains less well understood than their c… Show more

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Cited by 7 publications
(22 citation statements)
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“…Achieving uniform freezing throughout the scaffold is critical to avoid pore size and distribution heterogeneity, necessitating careful process optimization. [ 75 ] The non‐uniformity in the pore structure could compromise the overall integrity of the scaffold, potentially hindering its effectiveness in supporting cellular growth and tissue regeneration. In addition, maintaining the mechanical strength of the SF scaffold poses a critical challenge.…”
Section: Fabrication Techniques For Sf‐derived Fibrous Scaffoldsmentioning
confidence: 99%
“…Achieving uniform freezing throughout the scaffold is critical to avoid pore size and distribution heterogeneity, necessitating careful process optimization. [ 75 ] The non‐uniformity in the pore structure could compromise the overall integrity of the scaffold, potentially hindering its effectiveness in supporting cellular growth and tissue regeneration. In addition, maintaining the mechanical strength of the SF scaffold poses a critical challenge.…”
Section: Fabrication Techniques For Sf‐derived Fibrous Scaffoldsmentioning
confidence: 99%
“…These sponges have been shown to be advantageous due to their tunable initial mechanical properties and ability to maintain their structure while also providing adequate microenvironments for cell growth, differentiation, or maturation. [1][2][3][4][5][6][7] Previous work has demonstrated the tunability of silk sponge-like biomaterials through modulation of polymer molecular weight, polymer concentration, pore structure and diameter, and induced crystallinity within the silk fibroin protein. 3,5,8 These tunable factors allow for modulation of the initial internal structure and mechanical properties of the sponges.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4][5][6][7] Previous work has demonstrated the tunability of silk sponge-like biomaterials through modulation of polymer molecular weight, polymer concentration, pore structure and diameter, and induced crystallinity within the silk fibroin protein. 3,5,8 These tunable factors allow for modulation of the initial internal structure and mechanical properties of the sponges. Additionally, biomolecules can be included before or after the sponge formation to provide biologically relevant factors for different cellularized applications.…”
Section: Introductionmentioning
confidence: 99%
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