Impedance Characteristics of Stimulation Contacts in Deep Brain Stimulation of the Anterior Nucleus of the Thalamus and Its Relationship to Seizure Outcome in Patients With Refractory Epilepsy

Möttönen, Timo; Peltola, Jukka; Järvenpää, Soila; Haapasalo, Joonas; Kai, Li

doi:10.1016/j.neurom.2022.04.047

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…The contacts most centrally located within the ANT were selected for stimulation based on postoperative imaging whenever available. Impedance measurements were used to ensure that selected stimulation contacts were within brain tissue (and not cerebrospinal fluid) 38,39 . Thus, the conventional programming paradigm is to begin stimulation at 5 V with progressive increases at each clinic visit depending on seizure control or side effects.…”

Section: Discussionmentioning

confidence: 99%

Initial case series of a novel sensing deep brain stimulation device in drug‐resistant epilepsy and consistent identification of alpha/beta oscillatory activity: A feasibility study

et al. 2023

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ObjectiveHere, we report a retrospective, single‐center experience with a novel deep brain stimulation (DBS) device capable of chronic local field potential (LFP) recording in drug‐resistant epilepsy (DRE) and explore potential electrophysiological biomarkers that may aid DBS programming and outcome tracking.MethodsFive patients with DRE underwent thalamic DBS, targeting either the bilateral anterior (n = 3) or centromedian (n = 2) nuclei. Postoperative electrode lead localizations were visualized in Lead‐DBS software. Local field potentials recorded over 12–18 months were tracked, and changes in power were associated with patient events, medication changes, and stimulation. We utilized a combination of lead localization, in‐clinic broadband LFP recordings, real‐time LFP response to stimulation, and chronic recordings to guide DBS programming.ResultsFour patients (80%) experienced a >50% reduction in seizure frequency, whereas one patient had no significant reduction. Peaks in the alpha and/or beta frequency range were observed in the thalamic LFPs of each patient. Stimulation suppressed these LFP peaks in a dose‐dependent manner. Chronic timeline data identified changes in LFP amplitude associated with stimulation, seizure occurrences, and medication changes. We also noticed a circadian pattern of LFP amplitudes in all patients. Button‐presses during seizure events via a mobile application served as a digital seizure diary and were associated with elevations in LFP power.SignificanceWe describe an initial cohort of patients with DRE utilizing a novel sensing DBS device to characterize potential LFP biomarkers of epilepsy that may be associated with seizure control after DBS in DRE. We also present a new workflow utilizing the Percept device that may optimize DBS programming using real‐time and chronic LFP recording.

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Section: Discussionmentioning

confidence: 99%

Initial case series of a novel sensing deep brain stimulation device in drug‐resistant epilepsy and consistent identification of alpha/beta oscillatory activity: A feasibility study

et al. 2023

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“…Electrode contacts localizations within the anterior thalamic nuclei were confirmed by post-op MRI. The active stimulating leads were selected according to anatomical localization in the inferior aspect of the anterior thalamic nuclei as well as impedance measurements between neighboring leads, with a minimum value of 600 Ω set to ensure that contacts avoided CSF or the superficial area of the ATN [15] . DBS treatment was initiated a month after implantation, with initial stimulation parameters set to 5 V stimulation potential, 90 µs pulse width, 145 Hz, “ON” one minute and “OFF” five minutes.…”

Section: Methodsmentioning

confidence: 99%

Anterior thalamic deep brain stimulation in epilepsy patients refractory to vagus nerve stimulation: A single center observational study

Miron

Strauss

Fried

et al. 2022

Epilepsy & Behavior Reports

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Advancing thalamic neuromodulation in epilepsy: Bridging adult data to pediatric care

Samanta,

Aungaroon,

Albert

et al. 2024

Epilepsy Research

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Impedance Characteristics of Stimulation Contacts in Deep Brain Stimulation of the Anterior Nucleus of the Thalamus and Its Relationship to Seizure Outcome in Patients With Refractory Epilepsy

Cited by 5 publications

References 25 publications

Initial case series of a novel sensing deep brain stimulation device in drug‐resistant epilepsy and consistent identification of alpha/beta oscillatory activity: A feasibility study

Initial case series of a novel sensing deep brain stimulation device in drug‐resistant epilepsy and consistent identification of alpha/beta oscillatory activity: A feasibility study

Anterior thalamic deep brain stimulation in epilepsy patients refractory to vagus nerve stimulation: A single center observational study

Advancing thalamic neuromodulation in epilepsy: Bridging adult data to pediatric care

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