Impedance of tissue-mimicking phantom material under compression

Belmont, Barry; Dodde, Robert E.; Shih, Albert J.

doi:10.5617/jeb.443

Cited by 22 publications

(19 citation statements)

References 37 publications

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“…They suggest that the different resistivity of each type of tissue can be an indicator of its structure. Belmont's test [27] on a soft tissue-mimicking phantom showed a decrease in the admittance of the phantom under compression. They showed that tofu can be used as a suitable phantom for bioimpedance measurements under applied pressure.…”

Section: Introductionmentioning

confidence: 99%

Compression-dependency of soft tissue bioimpedance for in-vivo and in-vitro tissue testing

Moqadam

Grewal

Shokoufi

et al. 2015

Journal of Electrical Bioimpedance

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The present study determines the effect of compression over bioimpedance of healthy soft tissue (in-vitro and in-vivo). Electrical impedance spectroscopy (EIS) is a promising tissue characterization and tumor detection technique that uses tissue impedance or admittance to characterize tissue and identify tissue properties as well as cell structure. Variation in EIS measurements while applying pressure suggests that compression tends to affect soft tissue bioimpedance. Moreover, the displacements in tissue caused by applied compression may provide useful information about the structure and state of the tissue. Thus combining the changes to the electrical properties of tissue resulted by applied compression, with the changes in tissue displacements caused by applied compression, and consequently measuring the effect that electrical and mechanical properties have on each other, can be useful to identify tissue structure. In this study, multifrequency bioimpedance measurements were performed on in-vitro and invivo soft tissue at different pressure levels. Increasing compression on the in-vitro tissue results in an increase in both extracellular resistance and membrane capacitance while it causes a reduction in the intracellular resistance. However, as the compression over the in-vivo samples increases, the intracellular and extracellular resistance increase and the membrane capacitance decreases. The in-vivo measurements on human body are also tested on contralateral tissue sites and similar tissue impedance variation trends are observed in the contra-lateral sites of human body. The evidence from these tests suggests the possibility of using this EIS-Pressure combined measurement method to improve tumor detection in soft tissue. Based upon the observations, the authors envision developing an advanced model based upon the Cole model, which is dependent on tissue displacements.

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Section: Introductionmentioning

confidence: 99%

Compression-dependency of soft tissue bioimpedance for in-vivo and in-vitro tissue testing

Moqadam

Grewal

Shokoufi

et al. 2015

Journal of Electrical Bioimpedance

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“…3) was based on the tetrapolar BIS circuit designed and developed by Dodde et al [25,27,28,29]. Our system consisted of a BIS circuit, four platinum leaf probes, an oscilloscope (DSO7032B, Agilent Technologies, Santa Clara, CA), a single-axis programmable mechanical test stand (ESM301L, Mark-10, Copiague, NY), and a computer for automation and data acquisition.…”

Section: Methodsmentioning

confidence: 99%

“…Ohm's law was then used to calculate the impedance. Tetrapolar probes have been previously used in a number of BIS studies and are widely considered to be reliable [27,31]. The schematic for the circuit used in our compression BIS system is shown in Fig.…”

Section: Design and Characterization Of The Bis Circuitmentioning

confidence: 99%

“…The studies of Dodde et al [25] and Belmont et al [27] used an integrated tetrapolar probe. This probe was composed of a cylindrical composite plastic piece with holes drilled through its length and platinum wires inserted.…”

Section: Design and Characterization Of Bioimpedance Probesmentioning

confidence: 99%

“…Our work concentrated on strains up to approximately 33%, better relating to a clinical situation. Belmont et al examined the time-dependent electrical properties of a tissue mimicking material (tofu) under a constant strain loading [27]. Their work established the fundamental link between viscoelastic stress relaxation and impedance.…”

Section: Introductionmentioning

confidence: 99%

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The feasibility of using compression bioimpedance measurements to quantify peripheral edema

Koziol

Pitre

Bull

et al. 2014

Journal of Electrical Bioimpedance

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The accurate assessment of body fluid volume is important in many clinical situations, especially in the determination of "dry weight" in a dialysis setting. Currently, no clinically applicable diagnostic system exists to determine the mechanical properties that accurately characterize peripheral edema in an objective and quantitative manner. We have developed a method for quantifying the impact of compression on the electrical properties of tissue by measuring stress-induced changes in bioimpedance (BIS). Using this method, we simultaneously measured the impedance and mechanical response of a tissue mimicking material (tofu) under both quasi-static and dynamic loading conditions. Our results demonstrate a temporal quantification of viscoelastic properties using a viscoelastic phantom tissue model.

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Fabrication of a Gold Dual‐microelectrode Patterned on a Silicone Substrate Probe for the Discrimination of Different Tissues

et al. 2020

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A gold dual‐microelectrode probe patterned on a silicon substrate for bio‐impedance measurement was fabricated, characterised and tested on different types of tissues. The aim of this study is to fabricate a device capable of using bioimpedance to discriminate different tissue types. This proof of concept of the device was characterised on meat and a gel/lard phantom which mimics fat and muscle. The initial results demonstrated that the gold dual‐microelectrode probe had excellent electrochemical recording potential. The bio‐impedance data derived was capable of differentiation between biological tissues. Bio‐impedance measurement may enhance cancer diagnostics by providing novel data in relation to cancer and surrounding healthy tissue. This manuscript describes the design, fabrication and validation of a gold dual‐microelectrode bioimpedance sensor with a potential future application in cancer diagnostics.

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Impedance of tissue-mimicking phantom material under compression

Cited by 22 publications

References 37 publications

Compression-dependency of soft tissue bioimpedance for in-vivo and in-vitro tissue testing

Compression-dependency of soft tissue bioimpedance for in-vivo and in-vitro tissue testing

The feasibility of using compression bioimpedance measurements to quantify peripheral edema

Fabrication of a Gold Dual‐microelectrode Patterned on a Silicone Substrate Probe for the Discrimination of Different Tissues

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