The feasibility of using compression bioimpedance measurements to quantify peripheral edema

Abstract

The accurate assessment of body fluid volume is important in many clinical situations, especially in the determination of "dry weight" in a dialysis setting. Currently, no clinically applicable diagnostic system exists to determine the mechanical properties that accurately characterize peripheral edema in an objective and quantitative manner. We have developed a method for quantifying the impact of compression on the electrical properties of tissue by measuring stress-induced changes in bioimpedance (BIS). Using this method, we simultaneously measured the impedance and mechanical response of a tissue mimicking material (tofu) under both quasi-static and dynamic loading conditions. Our results demonstrate a temporal quantification of viscoelastic properties using a viscoelastic phantom tissue model.

A LabVIEW-based electrical bioimpedance spectroscopic data interpreter (LEBISDI) for biological tissue impedance analysis and equivalent circuit modelling

“…The resistive path created by the ICF in biological cells to an electric signal ( Figure 4a) is represented as a resistive element called ICF resistance (RICF). Alternatively, the capacitance [74] offered by the protein-lipid-protein structure [62][63] of the cell membrane is modeled as cell membrane capacitance (C CM ) [5][6] ( Figure 4a).…”

“…The electrical behavior of the tissues is usually quantified by its complex bioelectrical impedance [1][2][3][4], which is the physical quantity that we reconstruct from the experimental measurements. Because bioelectrical impedance depends on the physiological and physiochemical status of the probed tissue and because it also varies from subject to subject and with changes in the health status of the tissue [5][6], such as inflammation, infection and disease, studying how a tissue responds to frequency can provide valuable information about its anatomy and physiology. Many researchers [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] have investigated electrical bioimpedance as an effective, noninvasive method to probe the pathological status of biological tissues.…”