Impedimetric Plant Biosensor Based on Minimally Invasive and Flexible Microneedle Electrodes

Bukhamsin, Abdullah; Moussi, Khalil; Patel, Niketan S.; Przybysz, Alexander; Wang, Yajun; Krattinger, Simon G.; Kosel, Jürgen

doi:10.1109/mems46641.2020.9056158

Cited by 5 publications

(8 citation statements)

References 41 publications

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“…Previously, we demonstrated that analyzing the impedance spectrum of Barley leaves ( Hordeum vulgare ) has shown that the impedance at 10 Hz cycles in a diurnal fashion entrained by light. [ 10 ] Although the physiological phenomena explaining this cycling pattern are unclear, it may serve as a useful tool to assess light exposure of crops in a field, which is crucial for photosynthetic activities. As such, a specimen of Arabidopsis thaliana is monitored using the MNs‐equipped sensor for 12 d to discern if there is a cycling pattern that is also entrained by light similar to that of Barley.…”

Section: Resultsmentioning

confidence: 99%

“…Previously, we demonstrated that analyzing the impedance spectrum of Barley leaves (Hordeum vulgare) has shown that the impedance at 10 Hz cycles in a diurnal fashion entrained by light. [10] Although the physiological phenomena explaining this cycling pattern are unclear, it may serve as a useful tool to assess light exposure of crops in a field, which is crucial for Figure 6. A) Magnitude of electrical impedance recorded over time for frequencies between 10 Hz and 100 kHz.…”

Section: Elements Respectively For the Faraday Cage And Open-air Testsmentioning

confidence: 99%

“…[7] Borrowing a page from medicine, [8] minimally invasive microneedles (MNs) were developed to directly probe the relevant plant tissue, thereby bypassing the cuticle. As this approach gained traction, MNs were used for DNA extraction from leaves, [9] EIS measurement of plant tissue to probe the content of the EF [10,11] and to assess sap flow through the plant's stem. [12] Due to the breadth of their applications, several MN fabrication techniques were devised.…”

Section: Introductionmentioning

confidence: 99%

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Robust, Long‐Term, and Exceptionally Sensitive Microneedle‐Based Bioimpedance Sensor for Precision Farming

et al. 2021

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Precision farming has the potential to increase global food production capacity whilst minimizing traditional inputs. However, the adoption and impact of precision farming are contingent on the availability of sensors that can discern the state of crops, while not interfering with their growth. Electrical impedance spectroscopy offers an avenue for nondestructive monitoring of crops. To that end, it is reported on the deployment of impedimetric sensors utilizing microneedles (MNs) that can be used to pierce the waxy exterior of plants to obtain sensitive impedance spectra in open‐air settings with an average relative noise value of 3.83%. The sensors are fabricated using a novel micromolding and release method that is compatible with UV photocurable and thermosetting polymers. Assessments of the quality of the MNs under scanning electron microscopy show that the replication process is high in fidelity to the original design of the master mold and that it can be used for upward of 20 replication cycles. The sensor's performance is validated against conventional planar sensors for obtaining the impedance values of Arabidopsis thaliana. As a change is detected in impedance due to lighting and hydration, this raises the possibility for their widespread use in precision farming.

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Section: Resultsmentioning

confidence: 99%

“…Previously, we demonstrated that analyzing the impedance spectrum of Barley leaves (Hordeum vulgare) has shown that the impedance at 10 Hz cycles in a diurnal fashion entrained by light. [10] Although the physiological phenomena explaining this cycling pattern are unclear, it may serve as a useful tool to assess light exposure of crops in a field, which is crucial for Figure 6. A) Magnitude of electrical impedance recorded over time for frequencies between 10 Hz and 100 kHz.…”

Section: Elements Respectively For the Faraday Cage And Open-air Testsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Robust, Long‐Term, and Exceptionally Sensitive Microneedle‐Based Bioimpedance Sensor for Precision Farming

et al. 2021

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“…the first step of molding was eliminated. Bukhamsin et al [40] employed two-photon polymerization technique to form IP-S resin negative mold, which is similar to the previous mentioned 3D printing process for master molding [51]. Zhang et al [44] designed a novel method that mixed ferrofluid with trimethylolpropane ethoxylate triacrylate (ETPTA) to fabricate the ETPTA-based negative mold.…”

Section: Negative Moldmentioning

confidence: 99%

“…Due to the interspace of negative microneedle-shaped holes are too narrow to allow the casted liquid filling up spontaneously, vacuumization [40,43,46,48,55,56,59,92], centrifugation [47,[49][50][51][52][53]55] and positive pressure [42,45] are often employed to drive the liquid into the negative holes. Gao et al [43] added silk fibroin into the microneedles before casting the PEGDA prepolymer solution.…”

Section: Swellable Materialsmentioning

confidence: 99%

Recent advances on fabrication of microneedles on the flexible substrate

Huang

et al. 2021

J. Micromech. Microeng.

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Microneedles are able to penetrate into the skin and offer great chances in various biomedical applications including transdermal drug delivery, stable bio-signal monitoring, sampling and bio-sensing. Owing to the micro-scale feature size, microneedles have advantages of minimal invasiveness, pain, high biosafety and simple operation. However, it is still challenging to fabricate solid microneedles on a flexible substrate. This review primarily introduces recent studies about microneedles on the flexible substrate, various fabrication methods of microneedles on the flexible substrate, including micromolding, silicon dry/wet etching, electrochemical etching, drawing-lithography, electro-drawing lithography, magnetorheological drawing lithography, three-dimensional printing, vapor–liquid–solid grown, hot embossing, and assembly, and corresponding materials have been summarized and discussed in details. In the end, regular biomedical applications of microneedle on the flexible substrate are categorized into drug delivery, vaccine delivery, electrophysiological interaction, sampling and bio-sensing. Recent advances of each application have been discussed.

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Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives

Rad

2022

Adv Eng Mater

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The global food supply constantly faces the threats of emerging crop diseases initiated by pathogens such as bacteria, fungi, and viruses. Plant diseases can cause significant economic and production losses in the agriculture industry, and early disease detection significantly mitigates losses. Monitoring the food quality and detecting pathogens during the food supply chain is essential in confirming the food's safety and reducing crop loss. This results in lowering production costs and increasing average yield in the agriculture industry. Considering the significant development of nanotechnology in biomedicine for human health monitoring, diagnostics, and treatment, there is an increasing interest in using nanotechnology in crop production, health, and plant science. This technology can allow continuous monitoring of plant health and on‐site diagnostics of plant diseases. While many microneedle‐based devices are previously reported for human health monitoring, diagnostics, and treatment, the application of this technology to agriculture started relatively recently. This review investigates the recent development of microneedle technology in food and crop health, where the most state‐of‐the‐art microneedle‐based devices are utilized for plant drug delivery, disease monitoring, and diagnosis. Finally, the current challenges and future directions in developing microneedle technology for food and crop health are discussed.

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Impedimetric Plant Biosensor Based on Minimally Invasive and Flexible Microneedle Electrodes

Cited by 5 publications

References 41 publications

Robust, Long‐Term, and Exceptionally Sensitive Microneedle‐Based Bioimpedance Sensor for Precision Farming

Robust, Long‐Term, and Exceptionally Sensitive Microneedle‐Based Bioimpedance Sensor for Precision Farming

Recent advances on fabrication of microneedles on the flexible substrate

Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives

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