Imperatorin: A review of its pharmacology, toxicity and pharmacokinetics

Deng, Mao; Xie, Long; Zhong, Li; Liao, Yanmei; Liu, Luona; Li, Xiaofang

doi:10.1016/j.ejphar.2020.173124

Cited by 60 publications

(29 citation statements)

References 115 publications

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“…To date, a total of 153 coumarins have been isolated from the root and stem of A. dahurica, include 18 simple coumarins (1-18), 93 furanocoumarins (19-111), 41 coumarins glycosides (112-147), 3 other coumarins (148-150) and 3 coumarin derivatives (151-153). Among them, furanocoumarins are the most abundant coumarins, which are mainly divided into linear and angular types based on the location (Deng et al, 2020). Moreover, Other furanocoumarins such as isoimperatorin (19), oxypeucedanin (20), phellopterin (26) and byakangelicin (41) are also characteristic constituents of A. dahurica root with a wide range of bioactivities (Cho et al, 2006;Kang et al, 2008;Lee, B.W.…”

Section: Coumarinsmentioning

confidence: 99%

“…There are more than 150 coumarins have been identified from A. dahurica, including simple coumarins, furanocoumarins, coumarins glycosides, other coumarins and coumarin derivatives. Among them, furanocoumarin imperatorin (22, IMP, Figure 1) is the most representative coumarin in A. dahurica root (Deng et al, 2020). The volatile oils isolated from A. dahurica mainly include terpenes, aromatics, alcohols, aldehydes, ketones, acids, esters and alkanes.…”

Section: Introductionmentioning

confidence: 99%

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The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Zhao¹,

Feng

Wang

et al. 2022

Front. Pharmacol.

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Angelica dahurica (A. dahurica) root is a famous edible medicinal herb that has been used in China for thousands of years. To date, more than 300 chemical constituents have been discovered from A. dahurica. Among these ingredients, coumarins and volatile oils are the major active compounds. Moreover, a few other compounds have also been isolated from the root of A. dahurica, such as alkaloids, phenols, sterols, benzofurans, polyacetylenes and polysaccharides. Modern pharmacological studies demonstrated that the root of A. dahurica and its active components displayed various bioactivities such as anti-inflammation, anti-tumor, anti-oxidation, analgesic activity, antiviral and anti-microbial effects, effects on the cardiovascular system, neuroprotective function, hepatoprotective activity, effects on skin diseases and so on. Based on these studies, this review focused on the research publications of A. dahurica and aimed to summarize the advances in the traditional uses, phytochemistry and pharmacology which will provide reference for the further studies and applications of A. dahurica.

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Section: Coumarinsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Zhao¹,

Feng

Wang

et al. 2022

Front. Pharmacol.

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“…Imperatorin inhibits Sp1 and inhibits cyclin D1 expression, which stops the cell cycle at phase G1 (phase regulated by Sp1) [ 121 ]. On the other hand, in addition to the antiviral activity reported for this compound, it has been described as anti-inflammatory, anticancer, neuroprotective, antihypertensive, and antibacterial activity [ 122 , 123 ].…”

Section: Coumarinsmentioning

confidence: 99%

Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1

Serna-Arbeláez

Florez-Sampedro

Orozco

et al. 2021

Advances in Virology

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Infections caused by human immunodeficiency virus (HIV) are considered one of the main public health problems worldwide. Antiretroviral therapy (ART) is the current modality of treatment for HIV-1 infection. It comprises the combined use of several drugs and can decrease the viral load and increase the CD4+ T cell count in patients with HIV-1 infection, thereby proving to be an effective modality. This therapy significantly decreases the rate of morbidity and mortality owing to acquired immunodeficiency syndrome (AIDS) and prolongs and improves the quality of life of infected patients. However, nonadherence to ART may increase viral resistance to antiretroviral drugs and transmission of drug-resistant strains of HIV. Therefore, it is necessary to continue research for compounds with anti-HIV-1 activity, exhibiting a potential for the development of an alternative or complementary therapy to ART with low cost and fewer side effects. Natural products and their derivatives represent an excellent option owing to their therapeutic potential against HIV. Currently, the derivatives of natural products available as anti-HIV-1 agents include zidovudine, an arabinonucleoside derivative of the Caribbean marine sponge (Tectitethya crypta), which inhibits the reverse transcriptase of the virus. This was the first antiviral agent approved for treatment of HIV infection. Additionally, bevirimat (isolated from Syzygium claviflorum) and calanolide A (isolated from Calophyllum sp.) are inhibitors of viral maturation and reverse transcription process, respectively. In the present review, we aimed to describe the wide repertoire of natural compounds exhibiting anti-HIV-1 activity that can be considered for designing new therapeutic strategies to curb the HIV pandemic.

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“…Many authors discuss the photoreactivity of LF and its effects upon dermal administration [1,2,16]. Although the exact mechanisms underlying these effects are still unclear, literature attributes to the condensed aromatic system of Psoralens pro-oxidant properties [43,44]. In this sense, some reports supported this interpretation due to the increased formation of reactive oxygen species in the presence of LF and similar compounds [19,32,[44][45][46].…”

Section: Figurementioning

confidence: 99%

Exploring Cheminformatic Toolsets for Predicting the Dermal Toxicity of Furanocoumarins

Thomaz

Oliveira

Silva

et al. 2021

PoS

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Linear furanocoumarins are skin sensitizers and anticancer agents whose appeal in skincare therapeutics is widely exploited. Owing to the need to predict the biological activities of medicines, this work aimed the investigate the predicted dermal toxicity of linear furanocoumarins through chemoinformatic approaches. Therefore, eight major linear furanocoumarins of interest in medicine were selected, and their pharmacophores / toxicophores were modelled and inputted in several databases and cheminformatic toolsets previously described in the literature. Moreover, Principal Components Analysis was performed to allow multivariable comparisons. Results showcased that the first two PCs accounted for 95.48% of all variance in the model, and molecular weight and polar surface showcased a positive correlation to Log P and Log K p , which may be involved in skin penetration. Moreover, the pharmacophore modelling evidenced superimposition between linear furanocoumarins, ethidium bromide and acridine orange, thereby suggesting that these compounds share similar biological effects, supported by their acknowledged DNA intercalating activities. Therefore, this work showcased the application of various cheminformatic tools to screen the dermal toxicity of chemicals.

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Imperatorin: A review of its pharmacology, toxicity and pharmacokinetics

Cited by 60 publications

References 115 publications

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1

Exploring Cheminformatic Toolsets for Predicting the Dermal Toxicity of Furanocoumarins

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