Implant Debris: Clinical Data and Relevance

Hallab, NJ; Jacobs, JJ

doi:10.1016/b978-0-08-055294-1.00207-5

Cited by 4 publications

(6 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ursächlich könnte die mit einer möglichen Fremdkörperreaktion einhergehende erhöhte Osteoklastenaktivität sein, in deren Folge es zur periimplantären Knochenresorption kommt 46 . Denn die Aufnahme von Fremdpartikeln aktiviert Makrophagen zur Sekretion von TNF-α, IL- 1b, IL-6 und PGE2, was wiederum die Differenzierung von Osteoklastenvorläufern in reife Osteoklasten stimuliert.…”

Section: Vorläufige Ergebnisse Einer Quality-assessment-studieunclassified

“…Lösen diese sich beim Insertionsprozess des Implantats von der Oberfläche, so nehmen Makrophagen die Partikel durch Phagozytose auf und setzen in der Folge proinflammatorische Zytokine frei. Die Folge ist eine sich ausweitende Zone von Weichteilschäden und Entzündungen 46 . Einzelne verunreinigte Implantatmuster wurden im Nachgang der Studie zusätzlich einer aufwendigen ToF-SIMS-Analyse unterzogen.…”

Section: Vorläufige Ergebnisse Einer Quality-assessment-studieunclassified

See 1 more Smart Citation

Update Oberflächenanalysen: steril verpackte Implantate unter der Lupe

Duddeck¹,

Bollen²

2022

Zahnmedizin up2date

View full text Add to dashboard Cite

Section: Vorläufige Ergebnisse Einer Quality-assessment-studieunclassified

Update Oberflächenanalysen: steril verpackte Implantate unter der Lupe

Duddeck¹,

Bollen²

2022

Zahnmedizin up2date

View full text Add to dashboard Cite

“…As described earlier, these metal combinations (though in different proportions) are present in stents, prosthodontic and orthopaedic implants, such as ASTM F90 (Co-20Cr-15W-10Ni) [93][94][95][96]. No such carcinogenicity has been reported for these applications.…”

Section: Toxicity Of Tungstenmentioning

confidence: 99%

The use of tungsten as a chronically implanted material

Idil

Donaldson

2018

J. Neural Eng.

View full text Add to dashboard Cite

This review paper shows that tungsten should not generally be used as a chronically implanted material. The metal has a long implant history, from neuroscience, vascular medicine, radiography, orthopaedics, prosthodontics, and various other fields, primarily as a result of its high density, radiopacity, tensile strength, and yield point. However, a crucial material criterion for chronically implanted metals is their long-term resistance to corrosion in body fluids, either by inherently noble metallic surfaces, or by protective passivation layers of metal oxide. The latter is often assumed for elemental tungsten, with references to its 'inertness' and 'stability' common in the literature. This review argues that in the body, metallic tungsten fails this criterion, and will eventually dissolve into the soluble hexavalent form W, typically represented by the orthotungstate [Formula: see text] (monomeric tungstate) anion. This paper outlines the metal's unfavourable corrosion thermodynamics in the human physiological environment, the chemical pathways to either metallic or metal oxide dissolution, the rate-limiting steps, and the corrosion-accelerating effects of reactive oxidising species that the immune system produces post-implantation. Multiple examples of implant corrosion have been reported, with failure by dissolution to varying extents up to total loss, with associated emission of tungstate ions and elevated blood serum levels measured. The possible toxicity of these corrosion products has also been explored. As the field of medical implants grows and designers explore novel solutions to medical implant problems, the authors recommend the use of alternative materials.

show abstract

“…Recently, several in vitro and in vivo studies reported the action of macrophages in the implant neighboring, where important amounts of degradation products (ions and debris) may be present. [66][67][68][69][70] Particularly, Lee et al 71 studied the migration and activation of live macrophages close to titanium biomaterials and their degradation products. They found that macrophages were more abundant in the vicinity of metallic surfaces than in more remote areas, suggesting that the concentration of the degradation products would be inversely proportional to the distance from the biomaterial.…”

Section: Effect Of Individual Ions and Synergistic Cytotoxic Effects mentioning

confidence: 99%

Synergistic cytotoxic effects of ions released by zinc–aluminum bronze and the metallic salts on osteoblastic cells

Grillo

Morales

Mirífico

et al. 2013

J Biomedical Materials Res

View full text Add to dashboard Cite

The use of copper-based alloys for fixed dental crowns and bridges is increasingly widespread in several countries. The aim of this work is to study the dissolution of a zinc-aluminum-bronze and the cytotoxic effects of the ions released on UMR-106 osteoblastic cell line. Two sources of ions were used: (1) ions released by the metal alloy immersed in the cell culture and (2) salts of the metal ions. Conventional electrochemical techniques, atomic absorption spectroscopy [to obtain the average concentration of ions (AC) in solution], and energy dispersive X-ray (EDX) spectroscopy analysis were used to study the corrosion process. Corrosion tests revealed a strong influence of the composition of the electrolyte medium and the immersion time on the electrochemical response. The cytotoxicity was evaluated with (a) individual ions, (b) combinations of two ions, and (c) the mixture of all the ions released by a metal disc of the alloy. Importantly, synergistic cytotoxic effects were found when Al-Zn ion combinations were used at concentration levels lower than the cytotoxic threshold values of the individual ions. Cytotoxic effects in cells in the vicinity of the metal disc were also found. These results were interpreted considering synergistic effects and a diffusion controlled mechanism that yields to concentration levels, in the metal surroundings, several times higher than the measured AC value.

show abstract

Implant Debris: Clinical Data and Relevance

Cited by 4 publications

References 73 publications

Update Oberflächenanalysen: steril verpackte Implantate unter der Lupe

Update Oberflächenanalysen: steril verpackte Implantate unter der Lupe

The use of tungsten as a chronically implanted material

Synergistic cytotoxic effects of ions released by zinc–aluminum bronze and the metallic salts on osteoblastic cells

Contact Info

Product

Resources

About