“…Although chlorhexidine is described in the CIST protocol, 69 the most effective treatment to detoxify the implant surface has not been identified. 73 Many other surface treatments aimed at eradication of the biofilm have been described [73][74][75][76][77][78] ; these include EDTA, citric acid, hydrogen peroxide, local anesthetic, cetylpyridinium chloride, and tetracycline, among others. Mechanical debridement alone, as described in protocol A, is considered to be inadequate for this group of lesions as a result of the increased pocket depth, thus necessitating the effort at antisepsis.…”