Treatment of Peri-Implantitis and the Failing Implant

Robertson, Kevin; Shahbazian, Timothy; MacLeod, Stephen

doi:10.1016/j.cden.2014.10.007

Cited by 31 publications

(40 citation statements)

References 84 publications

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“…Therefore, the antimicrobial effect of chimeric peptide is not directly proportional to its length and number of structural groups, and there is a certain relationship between its function and the number of functional groups in microenvironment. 39,40 XPS analysis of the binding elements' compositions of the Ti surface conrmed the presence of C 1s, O 1s (531.18 eV), Na 1s (1071.83 eV), P 2p (133.19 eV), C l2p (198.69 eV), and Ti 2p 3 (458.30 eV) as the chief components, as shown in Fig. 3.…”

Section: Comparison Of the Structure And Function Of Chimeric Peptidesmentioning

confidence: 96%

“…The overall goal of controlling peri-implantitis is to address the inammation of peri-implant mucosa and to prevent the further loss of bone tissue. 3,4 Because of the structure of implants and other factors, pre-existing peri-implantitis results in unsatisfactory treatment outcomes. [5][6][7] Results from animal experiments show positive outcomes with the use of anti-infective measures and prevent peri-implantitis over the course of treatment.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the structure and function of a chimeric peptide modified titanium surface

et al. 2019

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Section: Comparison Of the Structure And Function Of Chimeric Peptidesmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Comparison of the structure and function of a chimeric peptide modified titanium surface

et al. 2019

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“…However, due to the special structure of the epithelial cuff, its defense ability weakened, and bacteria are easy to penetrate. Once bacteria break through the epithelial cuff, they can quickly colonize the bone tissue, causing the damage to the soft and hard tissue surrounding the implant, and forming in ammation of the tissue around the implant [3].…”

Section: Introductionmentioning

confidence: 99%

Development of An Immunogenomic Landscape For The Competing Endogenous RNAs Network of Peri-Implantitis

Zheng

Gong

et al. 2020

Preprint

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Background: Peri-implantitis is an inflammation that occurs around the implant, resulting in varying degrees of inflammatory damage to the soft and hard tissues. The characteristic criterion is the loss of the supporting bone in an inflammatory environment. However, the specific mechanisms and biomarkers involved in peri-implantitis remain to be further studied. Recently, competing endogenous RNAs (ceRNA) and immune microenvironment have been found to play a more important role in the inflammatory process. In our study, we analyzed the expression of immune related microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and message RNAs (mRNAs) in peri-implantitis by analyzing GSE33774 and GSE57631.Methods: In this study, we explored the expression profile data of immune-related lncRNAs, miRNAs and mRNAs, and constructed immune-related ceRNA network involved in the pathogenesis of peri-implantitis. In addition, the CIBERSORT was used to evaluate the content of immune cells in normal tissues and peri-implantitis to detect the immune microenvironment of peri-implantitis.Results: In the analysis, the corresponding lncRNAs, 14 DElncRNAs, 16 DEmiRNAs, and 18 DEmRNAs were used to establish an immune related ceRNA network constructed and the immune infiltration patterns associated with peri-implantitis was discovered. Through the mutual verification of the two datasets, we found that GSK3B and miR-1297 may have important significance in the immune microenvironment and pathogenesis of peri-implantitis and GSK3B was closely related to four types of immune cells, which needs to be further proved by later experiments. Conclusions: Through immune-related ceRNA network, IRGs and immune cell infiltration can further comprehensively understand the pathogenesis of peri-implantitis, which built up an immunogenomic landscape with clinical significance for peri-implantitis.One-sentences summary: GSK3B and miR-1297 may have important significance in the immune microenvironment and pathogenesis of peri-implantitis.

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“…Dental implants are widely used for reconstruction, for functional and aesthetic problems, in partially and fully edentulous patients. Although dental implants are a predictable treatment option, they occasionally fail for a variety of reasons [1]. One reason is peri-implantitis, which is a late complication of dental implants and the primary process that leads to late failure [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Novel Micro-Arc Oxidation Implant Material on Preventing Peri-Implantitis

Huang

Zhou

et al. 2019

Coatings

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Dental implants occasionally fail for many reasons, especially peri-implantitis. The adhesion of bacteria to the surface of titanium is the initial factor in peri-implantitis. Therefore, the aim of this study was to assess the effect of a novel micro-arc oxidation (MAO) titanium on bacteria inhibition and regulation through periodontitis, and on a healthy saliva-derived biofilm, in vitro. MAO, sandblasting and acid etching (SLA), machined titanium and plasma-sprayed hydroxyapatite (HA) were selected for further study. The metabolic activity and biomass accumulation were tested using MTT (3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide) and crystal violet assay after 24 h of anaerobic incubation. The structure was determined by scanning electron microscopy (SEM) and live/dead staining. Moreover, 16S rDNA sequencing was used to assess the microbial community. The results showed that biofilms on MAO were thinner compared to HA and SLA. In the periodontitis group, the biofilm accumulation and metabolic activity reached the highest levels in the HA group (p < 0.05); MAO titanium had the smallest biofilm accumulation and higher live/dead ratio; and the relative abundance of Lactobacillus in the SLA, HA and MAO groups increased significantly compared to the machined group (p < 0.05). In the healthy group, the relative abundance of Lactobacillus in the MAO group increased significantly compared to the other three groups (p < 0.05); the amount and metabolism activity of bacteria in the MAO group was lower (p < 0.05); MAO titanium had the least biofilm accumulation and a higher live/dead ratio. In conclusion, the novel MAO titanium had the ability to combat peri-implantitis by inhibiting the biofilm and regulating the microbial ecosystem to healthier conditions.

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Treatment of Peri-Implantitis and the Failing Implant

Cited by 31 publications

References 84 publications

Comparison of the structure and function of a chimeric peptide modified titanium surface

Comparison of the structure and function of a chimeric peptide modified titanium surface

Development of An Immunogenomic Landscape For The Competing Endogenous RNAs Network of Peri-Implantitis

Effect of Novel Micro-Arc Oxidation Implant Material on Preventing Peri-Implantitis

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