Implantable Biosensors

Córcoles, Emma P.; Boutelle, Martyn G.

doi:10.1007/978-3-319-00360-3_5

Cited by 9 publications

(8 citation statements)

References 114 publications

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“…A device could sample a small percentage of the analyte with a high perfusion rate, achieving greater temporal resolution. However, capturing a high percentage of the source signal requires the concentrations on either side of the membrane to approach equilibrium, and, thus, a lower perfusion rate [72], and lower temporal resolution.…”

Section: Theorymentioning

confidence: 99%

Droplets for Sampling and Transport of Chemical Signals in Biosensing: A Review

2019

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The chemical, temporal, and spatial resolution of chemical signals that are sampled and transported with continuous flow is limited because of Taylor dispersion. Droplets have been used to solve this problem by digitizing chemical signals into discrete segments that can be transported for a long distance or a long time without loss of chemical, temporal or spatial precision. In this review, we describe Taylor dispersion, sampling theory, and Laplace pressure, and give examples of sampling probes that have used droplets to sample or/and transport fluid from a continuous medium, such as cell culture or nerve tissue, for external analysis. The examples are categorized, as follows: (1) Aqueous-phase sampling with downstream droplet formation; (2) preformed droplets for sampling; and (3) droplets formed near the analyte source. Finally, strategies for downstream sample recovery for conventional analysis are described.

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Section: Theorymentioning

confidence: 99%

Droplets for Sampling and Transport of Chemical Signals in Biosensing: A Review

2019

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“…When compared with other hyphenated techniques, the LC—MS technique is generally applicable with MD for separation and analysis. In recent years, MD–LC–MS has been widely used in the pharmacy, biology, clinical medicine and other fields, especially in the field of biopharmaceutical analysis analyzing complex biological matrices such as whole blood 69 , 70 , plasma 71 , 72 , and urine 73 , 74 , etc.…”

Section: New Technology Of On-line Biological Sample Processingmentioning

confidence: 99%

New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis

Peng

Tang

Zhou

et al. 2016

Acta Pharmaceutica Sinica B

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Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this paper summarizes several new techniques of on-line biological sample processing: solid phase extraction, solid phase micro-extraction, column switching, limited intake filler, molecularly imprinted solid phase extraction, tubular column, and micro-dialysis. We describe new developments, principles, and characteristics of these techniques, and the application of liquid chromatography–mass spectrometry (LC–MS) in biopharmaceutical analysis with these new techniques in on-line biological sample processing.

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“…The market for smart sensors is likely to increase to USD 6.7 billion by 2017, as advances in microelectromechanical systems (MEMS) fabrication techniques drive down sensor manufacturing costs (PRWeb, 2012). As the dimensions of smart sensors continue to decrease, new applications are sure to emerge, such as implantable biosensors (Córcoles et al, 2013).…”

Section: Smart Sensorsmentioning

confidence: 99%