Implantable drug delivery systems

Major, Ian; Lastakchi, Sarah; Dalton, Maurice; McConville, Christopher

doi:10.1016/b978-0-08-102548-2.00005-6

Cited by 11 publications

(4 citation statements)

References 198 publications

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“…One of the most prominent earlier examples of a clinically used polymer IDDS is Gliadel wafer, a chemotherapy drug-eluting device applied in treatment of glioblastoma [ 83 , 84 ]. There is also a significant market segment taken by non-biodegradable and reservoir-type implants [ 85 , 86 ]. The approval procedure for IDDS depends on the classification criteria, roughly discriminating between the “drug”, “biological agent”, “device” or a “combination product” [ 82 ].…”

Section: Discussionmentioning

confidence: 99%

Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis

et al. 2021

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Peri-implant fibrosis (PIF) increases the postsurgical risks after implantation and limits the efficacy of the implantable drug delivery systems (IDDS). Pirfenidone (PF) is an oral anti-fibrotic drug with a short (<3 h) circulation half-life and strong adverse side effects. In the current study, disk-shaped IDDS prototype combining polylactic acid (PLA) and PF, PLA@PF, with prolonged (~3 days) PF release (in vitro) was prepared. The effects of the PLA@PF implants on PIF were examined in the rabbit ear skin pocket model on postoperative days (POD) 30 and 60. Matching blank PLA implants (PLA0) and PLA0 with an equivalent single-dose PF injection performed on POD0 (PLA0+injPF) served as control. On POD30, the intergroup differences were observed in α-SMA, iNOS and arginase-1 expressions in PLA@PF and PLA0+injPF groups vs. PLA0. On POD60, PIF was significantly reduced in PLA@PF group. The peri-implant tissue thickness decreased (532 ± 98 µm vs. >1100 µm in control groups) approaching the intact derma thickness value (302 ± 15 µm). In PLA@PF group, the implant biodegradation developed faster, while arginase-1 expression was suppressed in comparison with other groups. This study proves the feasibility of the local control of fibrotic response on implants via modulation of foreign body reaction with slowly biodegradable PF-loaded IDDS.

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Section: Discussionmentioning

confidence: 99%

Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis

et al. 2021

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“…The congealed mass was allowed to air dry for 72 h at room temperature in an aseptic cabinet. After drying, the implants were removed from the petri dish and cut into 4 mm wide and 2 mm long rods with a stainless-steel cutter (Rajgor et al, 2011).…”

Section: Preparation Of Implantsmentioning

confidence: 99%

“…Pharmaceutical implants are small sterile solid masses containing a highly potent and purified active pharmaceutical ingredient that are intended to be subcutaneously implanted beneath the skin using a suitable special injector or surgical incision to provide continuous release of the active medicament over a long period of time (Wang et al, 2010;Rajgor et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Influence of carnauba wax on the release profile of ibuprofen implants

AİREMWEN

ISESELE²,

OBARİSİAGBON³

et al. 2022

EMU Journal of Pharmaceutical Sciences

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Pharmaceutical implants are small sterile solid masses usually cylindrical consisting of a highly potent and purified drug intended to be subcutaneously implanted beneath the skin by suitable special injector or by surgical incision for the purpose of providing the continuous release of the active medicament over a prolonged period of time. The purpose of this study was to evaluate the influence of carnauba wax on the release profile of ibuprofen implants. The implants were prepared with gelatin, hydroxypropyl methylcellulose admixture (80:20) and varying amount of carnauba wax (2.5%, 5%, 7.5%) using the solvent casting technique. Another batch of the implant was formulated without the incorporation of carnauba wax. Glycerin was used as the plasticizing agent. The physicochemical properties and the release kinetics of the implants were evaluated. The implant pellets had a similar appearance with minimal batch to batch variation. The mean diameter/thickness of the implants ranged from 2.46±0.10-2.86±0.03 mm, the percentage drug content was ≤96.92±0.12% and the swelling index values were between 2.68±0.01 -4.87±0.01%. The rate of drug release from the ibuprofen implants was significantly affected by the incorporation of carnauba wax. The higher the amount of carnauba wax incorporated in the formulation, the more retarded the rate of drug release. This can be exploited in the formulation of sustained release ibuprofen implants for the management of chronic diseases such as arthritis.

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“…(e.g., dominated by either passive diffusion, supported by artificial osmotic gradients, or enhanced by mechanically , thermally , magnetically , etc.–activated convection). The diversity of IDDSs, including the material, engineering, and drug release features, is comprehensively reviewed elsewhere [ 7 , 9 , 12 , 14 , 15 , 18 , 19 , 20 ]. For the purposes of this review, the most important categories are the anatomical placement of the IDDS, whether it has to be removed from the body after some time, and whether and to what extent it is biodegradable or bioerodible.…”

Section: Introductionmentioning

confidence: 99%

Implantable Drug Delivery Systems and Foreign Body Reaction: Traversing the Current Clinical Landscape

et al. 2021

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Precise delivery of therapeutics to the target structures is essential for treatment efficiency and safety. Drug administration via conventional routes requires overcoming multiple transport barriers to achieve and maintain the local drug concentration and commonly results in unwanted off-target effects. Patients’ compliance with the treatment schedule remains another challenge. Implantable drug delivery systems (IDDSs) provide a way to solve these problems. IDDSs are bioengineering devices surgically placed inside the patient’s tissues to avoid first-pass metabolism and reduce the systemic toxicity of the drug by eluting the therapeutic payload in the vicinity of the target tissues. IDDSs present an impressive example of successful translation of the research and engineering findings to the patient’s bedside. It is envisaged that the IDDS technologies will grow exponentially in the coming years. However, to pave the way for this progress, it is essential to learn lessons from the past and present of IDDSs clinical applications. The efficiency and safety of the drug-eluting implants depend on the interactions between the device and the hosting tissues. In this review, we address this need and analyze the clinical landscape of the FDA-approved IDDSs applications in the context of the foreign body reaction, a key aspect of implant–tissue integration.

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Implantable drug delivery systems

Cited by 11 publications

References 198 publications

Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis

Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis

Influence of carnauba wax on the release profile of ibuprofen implants

Implantable Drug Delivery Systems and Foreign Body Reaction: Traversing the Current Clinical Landscape

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