Implantable Nanofiber Membranes with Synergistic Photothermal and Autophagy Inhibition Effects for Enhanced Tumor Therapy Efficacy

Mu, Jiaxiang; Meng, Ziyang; Liu, Xinran; Guan, Ping; Lian, He

doi:10.1007/s42765-023-00311-6

Adv. Fiber Mater.

2023

DOI: 10.1007/s42765-023-00311-6

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Implantable Nanofiber Membranes with Synergistic Photothermal and Autophagy Inhibition Effects for Enhanced Tumor Therapy Efficacy

Jiaxiang Mu

Ziyang Meng

Xinran Liu

et al.

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2024

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Cited by 14 publications

References 47 publications

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Erythrocyte‐Membrane‐Camouflaged Magnetic Nanocapsules With Photothermal/Magnetothermal Effects for Thrombolysis

Zhu,

Lian,

et al. 2024

Adv Healthcare Materials

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Venous/arterial thrombosis poses significant threats to human health. However, drug‐enabled thrombolysis treatment often encounters challenges such as a short half‐life and low bioavailability. To address these issues, we report the design of erythrocyte‐membrane (EM) camouflaged nanocapsules (USIO/UK@EM) incorporating ultra‐small iron oxide (USIO) and urokinase (UK) drug, which exhibit remarkable photothermal/magnetothermal effects and drug delivery ability for venous and arterial thrombolysis. USIO, UK, and EM were coextruded to fabricate USIO/UK@EM with average sizes of 103.7 nm. Since USIO/UK@EM possesses wide photoabsorption characteristics and good magnetic properties, its solution demonstrates a remarkable temperature increase to 41.8‐42.9 °C within 5 min when exposed to an 808 nm laser (0.33 mW cm−2) or an alternating magnetic field (AMF). Such photothermal/magnetothermal effect along with UK confers impressive thrombolytic rates of 82.4% and 74.2%, higher than that (∼15%) achieved by UK alone. Furthermore, the EM coating extends the circulating half‐life (t1/2 = 3.28 h). When USIO/UK@EM are administered to mice and rabbits, tail vein thrombus in mice and femoral artery thrombus in rabbits can be dissolved by the synergetic effect of thermothrombolysis and UK. Therefore, this study not only offers insights into the rational design of multifunctional biomimetic nanocapsules but also showcases a promising thrombolysis strategy utilizing nanomedicine.This article is protected by copyright. All rights reserved

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Erythrocyte‐Membrane‐Camouflaged Magnetic Nanocapsules With Photothermal/Magnetothermal Effects for Thrombolysis

Zhu,

Lian,

et al. 2024

Adv Healthcare Materials

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Biomimetic Transparent Slippery Surface for the Locomotion of Photocontrol Droplets and Bubbles

Yu,

Guo

2024

Small

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Directed transportation and collection of liquids and bubbles play a vital role in the survival of ecosystems. Among them, the optical response control is widely used in the fields of microfluidic chips and chemical synthesis because of its high remote operation and fast response speed. However, due to poor light transmission, the development direction of traditional near‐infrared (NIR) absorbing materials in the field of visualization is limited, and there are few reports of manufacturing an operating platform that can realize the directional movement of droplets/bubbles on a single platform. Here, a transparent photo‐responsive PBFS platform is prepared for droplet and bubble manipulation by coating the etched glass substrate with Prussian blue (PB) nanocubes. When near‐infrared (NIR) irradiation on the PBFS platform, PB nanocubes trigger heat production by photothermal means, due to the action of Marangoni force, the surface tension on the left and right sides of the droplets and bubbles is not uniform, forming a surface tension gradient, thereby driving the movement of the droplets and bubbles. The control platform has good application potential in the field of microchemical reaction and biomedical engineering and brings new solutions to the field of transparent photothermal materials.

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Dressing and undressing MOF nanophotosensitizers to manipulate phototoxicity for precise therapy of tumors

Tao,

Yu,

Ren

et al. 2024

Acta Biomaterialia

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Implantable Nanofiber Membranes with Synergistic Photothermal and Autophagy Inhibition Effects for Enhanced Tumor Therapy Efficacy

Cited by 14 publications

References 47 publications

Erythrocyte‐Membrane‐Camouflaged Magnetic Nanocapsules With Photothermal/Magnetothermal Effects for Thrombolysis

Erythrocyte‐Membrane‐Camouflaged Magnetic Nanocapsules With Photothermal/Magnetothermal Effects for Thrombolysis

Biomimetic Transparent Slippery Surface for the Locomotion of Photocontrol Droplets and Bubbles

Dressing and undressing MOF nanophotosensitizers to manipulate phototoxicity for precise therapy of tumors

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