Implantación de condrocitos autólogos versus microfracturas para el tratamiento de lesiones del  cartílago en la rodilla

Ortega-Orozco, Rafael; Olague-Franco, JK; Miranda-Ramírez, E

doi:10.35366/85425

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…There are several therapeutic modalities that aim to reduce pain and restoring cartilage function. These strategies can be medical treatments such as pharmacological therapy, or surgical treatments such as palliative therapies (e.g., chondroplasty and debridement), repair techniques (e.g., drilling and microfracture), restorative techniques (e.g., tissue engineering) or prosthetic replacement [90,[142][143][144][145][146][147].…”

Section: Methods Of Cartilage Tissue Reparationmentioning

confidence: 99%

Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects

Alcaide‐Ruggiero

Molina-Hernández

Granados

et al. 2021

IJMS

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Several collagen subtypes have been identified in hyaline articular cartilage. The main and most abundant collagens are type II, IX and XI collagens. The minor and less abundant collagens are type III, IV, V, VI, X, XII, XIV, XVI, XXII, and XXVII collagens. All these collagens have been found to play a key role in healthy cartilage, regardless of whether they are more or less abundant. Additionally, an exhaustive evaluation of collagen fibrils in a repaired cartilage tissue after a chondral lesion is necessary to determine the quality of the repaired tissue and even whether or not this repaired tissue is considered hyaline cartilage. Therefore, this review aims to describe in depth all the collagen types found in the normal articular cartilage structure, and based on this, establish the parameters that allow one to consider a repaired cartilage tissue as a hyaline cartilage.

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Section: Methods Of Cartilage Tissue Reparationmentioning

confidence: 99%

Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects

Alcaide‐Ruggiero

Molina-Hernández

Granados

et al. 2021

IJMS

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“…Some studies show that the fibrocartilaginous repair site can deteriorate 1-2 years postsurgery [15], while others revealed deterioration of function during the intermediate (2-5 years) postoperative period with intra-lesional osteophytic formation and bone overgrowth [8,15]. Revision rates of 2.5%-6% at 2 years postoperatively and 9%-31% at 5 years postoperatively have been reported [20].…”

Section: Introductionmentioning

confidence: 99%

Viable cartilage allograft outperforms existing treatments for focal knee cartilage defects

Desai,

Assid,

Jacobs

et al. 2024

Knee surg. sports traumatol. arthrosc.

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PurposeViable cartilage allograft (VCA) is a cartilage tissue matrix that contains cryopreserved viable allogeneic cartilage fibres. This study aimed to assess safety and benefits in treating focal knee cartilage defects with VCA. We hypothesized that VCA is a safe single‐stage procedure in isolated chondral defects.MethodIn vitro analysis, in vivo studies and a prospective case series were performed. VCA was evaluated in a goat cartilage repair model. Symptomatic International Cartilage Repair Society grade 3/4A lesions of the femoral condyle or patella were implanted with VCA. International Knee Documentation Committee (IKDC), Knee injury and Osteoarthritis Outcome (KOOS) subscales, Lysholm, Short Form‐12, Visual Analog Scale and pain frequency levels were assessed. Radiographic and magnetic resonance imaging (MRI) was performed at regular intervals postoperatively. Data were analysed by statisticians to determine the power and significance of the results.ResultsThe goat study confirmed that VCA is effective for cartilage repair. Twenty patients were implanted; the mean age was 28.1 (16–56), the mean body mass index (BMI) was 27.9 ± 5.6 and the mean follow‐up was 24.1 months (range = 12.0–36.0 months). Lesions were in either the femoral condyle (7) or patella (13). Lesion sizes ranged from 1.5 to 6.0 cm2 (mean = 4.58 cm2). Outcome scores improved from preoperative baseline (POB): IKDC (78.2), Lysholm (89.0), KOOS: Pain (95.8), Symptoms (86.3), ADL (87.8), Sports (85.0) and QOL (75.0). MRI imaging demonstrated excellent osteochondral allograft assimilation. Second‐look arthroscopy (two patients) demonstrated complete fill and incorporation (Brittberg scores 11/12). Functional scores were maintained at 24 (M): IKDC (86.24 ± 17.2), Lysholm (87.23 ± 15.0), KOOS: Pain (91.72 ± 17.3), Symptoms (84.92 ± 16.1), ADLs (93.80 ± 16.1), Sports (84.45 ± 27.7), QOL (81.30 ± 20.8).ConclusionVCA is an off‐the‐shelf, single‐stage, conformable allogeneic graft that treats chondral defects with no additional fixation. Preclinical and short‐term prospective clinical studies show that VCA can safely treat chondral defects with potential advantages to existing options.Level of EvidenceLevel IV study.

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“…[22][23][24][25]17 Surgical techniques such as Autologous Chondrocyte Implantation (ACI), Matrix Autologous Chondrocyte Implantation (MACI), and particulated juvenile allograft cartilage have been created to regenerate tissue at the lesion site and demonstrate promising clinical results. 26,[28][29][30][31][32][33][34][35] Osteochondral allografting is a procedure that has been around for decades and has demonstrated consistently good results in the treatment of isolated articular cartilage lesions. [36][37][38][39][40] One of the concerns with traditional osteochondral allografting is that a significant amount of recipient bone must be cored out to allow for implantation of the donor graft.…”

Section: Introductionmentioning

confidence: 99%

Short term clinical outcomes of a Prochondrix® thin laser-etched osteochondral allograft for the treatment of articular cartilage defects in the knee

Mehta

Santoro

et al. 2022

J Orthop Surg (Hong Kong)

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Objective: The purpose of this study is to evaluate the short-term clinical outcomes of Prochondrix® novel thin, laser-etched osteochondral allograft on isolated articular cartilage defects. Methods: Eighteen patients with isolated, symptomatic, full-thickness articular cartilage lesions were treated with marrow stimulation followed by placement of a T-LE allograft. Demographic and intra-operative data was recorded as well as pre- and post-operative International Knee Documentation Committee (IKDC), Short Form-36 (SF-36), Knee Injury and Osteoarthritis Outcome Score (KOOS), Visual Analogue Scale (VAS) and Tegner scores. Pre- and post-operative data was compared at 6, 12, 24 and 36 months post operatively. Failures requiring reoperation were also recorded. Results: At a mean follow-up of 2.5 years (6–43 months), VAS decreased from 6.55 to 2.55 ( p = .02) and subjective IKDC scores increased from 37.61 to 59.65 ( p = .02). Statistically significant increases were also seen in KOOS Function-Sports and Recreational Activities (+26.04, p = .04) and KOOS QOL (+18.76, p = .007) as well as in SF-36 Physical Functioning (+25.20, p = .04), Energy/Fatigue (+16.50, p = .02), Social Functioning (+11.79, p = .04), and Bodily Pain (+25.18, p = .04). There were two failures requiring reoperation: one conversion to a patellofemoral arthroplasty (PFA), and one graft dislodgement which required removal. Conclusion: Treatment of articular cartilage lesions of the knee with ProChondrix® has demonstrated sustained positive results out to a mean follow-up of two and a half years in this prospective case series with a low failure rate that required reoperation (2 patients) in this series. These results are comparable to the short-term results of other cartilage restoration procedures currently in use today. A meta-analysis of osteochondral allografting demonstrated a mean 86.7% survival rate at 5 years with significant improvements in clinical outcome scores reaching MCID values.

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Implantación de condrocitos autólogos versus microfracturas para el tratamiento de lesiones del cartílago en la rodilla

Cited by 4 publications

References 29 publications

Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects

Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects

Viable cartilage allograft outperforms existing treatments for focal knee cartilage defects

Short term clinical outcomes of a Prochondrix® thin laser-etched osteochondral allograft for the treatment of articular cartilage defects in the knee

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