Implantation of an Intraosseous Transcutaneous Amputation Prosthesis Restoring Ambulation After Amputation of the Distal Aspect of the Left Tibia in an Arabian Tahr (Arabitragus jayakari)

Golachowski, Andrzej; Ghabri, Masoud Rashid Al; Golachowska, Barbara; Abri, Hamood Al; Lubak, Marek; Sujeta, Michal

doi:10.3389/fvets.2019.00182

Cited by 4 publications

(12 citation statements)

References 13 publications

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“…On the other hand, a self‐assembly method was used to engineer a dermal tissue, grown around Ti pegs and subsequently evaluate the adhesion strength at the interface skin substitute/implant. To date, most of studies done to evaluate skin sealing around transcutaneous devices were performed in animal models, such as dogs 8 and arabien tahr 23 . However, in vivo studies are very laborious, time‐consuming and costly.…”

Section: Discussionmentioning

confidence: 99%

Fibronectin grafting to enhance skin sealing around transcutaneous titanium implant

Ghadhab

Bilem

Guay‐Bégin

et al. 2021

J Biomedical Materials Res

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Intraosseous transcutaneous amputation prosthesis is a new approach in orthopedic implants that overcomes socket prosthesis problems. Its long‐term performance requires a tight skin‐implant seal to prevent infections. In this study, fibronectin (Fn), a widely used adhesion protein, was adsorbed or grafted onto titanium alloy. Fn grafting was performed using two different linking arms, dopamine/glutaric anhydride or phosphonate. The characterization of Fn‐modified surfaces showed that Fn grating via phosphonate has led to the highest amount of Fn cell‐binding site (RGD, arginine, glycine, and aspartate) available on the surface. Interestingly, cell culture studies revealed a strong correlation between the amount of available RGD ligands and cellular behavior, since enhanced proliferation and spreading of fibroblasts were noticed on Fn‐grafted surfaces via phosphonate. In addition, an original in vitro mechanical test, inspired from the real situation, to better predict clinical outcomes after implant insertion, has been developed. Tensile test data showed that the adhesion strength of a bio‐engineered dermal tissue was significantly higher around Fn‐grafted surfaces via phosphonate, as compared to untreated surfaces. This study sheds light on the importance of an appropriate selection of the linking arm to tightly control the spatial conformation of biomolecules on the material surface, and consequently cell interactions at the interface tissue/implant.

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Section: Discussionmentioning

confidence: 99%

Fibronectin grafting to enhance skin sealing around transcutaneous titanium implant

Ghadhab

Bilem

Guay‐Bégin

et al. 2021

J Biomedical Materials Res

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“…For contraindicated cases of full-limb amputation or when owners are reluctant for such a procedure to be carried out, a distal partial limb amputation could be considered for replacing that injured portion with a prosthetic device (Fitzpatrick et al, 2011;Séguin and Weigel, 2012;Farrell et al, 2014;Mich, 2014;Phillips et al, 2017;Golachowski et al, 2019;Wendland et al, 2019). Prosthetic devices could be a socket prosthesis or exoendoprosthesis (Mich, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Besides, better proprioception, no delay in load transfer, comfort, and energetic efficiency all have been described (Fitzpatrick et al, 2011;DeVasConCellos et al, 2012;Pitkin, 2013;Phillips et al, 2017). Exo-endoprosthesis complications have been reported, such as device failure, aseptic loss, marsupialization or skin breakdown, avulsion, and infection (Drygas et al, 2008;Fitzpatrick et al, 2011;DeVasConCellos et al, 2012;Golachowski et al, 2019). There are published clinical reports for exo-endoprosthesis for different animal species (Drygas et al, 2008;Fitzpatrick et al, 2011;Golachowski et al, 2019) or experimental models (Hall, 1976;Pitkin, 2013;Farrell et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Exo-endoprosthesis complications have been reported, such as device failure, aseptic loss, marsupialization or skin breakdown, avulsion, and infection (Drygas et al, 2008;Fitzpatrick et al, 2011;DeVasConCellos et al, 2012;Golachowski et al, 2019). There are published clinical reports for exo-endoprosthesis for different animal species (Drygas et al, 2008;Fitzpatrick et al, 2011;Golachowski et al, 2019) or experimental models (Hall, 1976;Pitkin, 2013;Farrell et al, 2014). All these devices are of press-fit designs, while no screw-type endoprosthesis has been described for clinical cases as in the human medicine field (Brånemark et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…All of the reported animal exo-endoprostheses used different metal alloys as the main material (Drygas et al, 2008;Fitzpatrick et al, 2011;DeVasConCellos et al, 2012;Farrell et al, 2014;Golachowski et al, 2019). Two of these are fabricated by additive manufacturing for metal materials using direct metal laser sintering technology (DMLS) (DeVasConCellos et al, 2012;Golachowski et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Test of Designing and Manufacturing a Polyether Ether Ketone Endoprosthesis for Canine Extremities by 3D Printing

Mendaza-DeCal

Peso-Fernandez²,

Rodríguez-Quiros

2021

Front. Mech. Eng.

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Total limb amputation is quite common in small animals, although most of the indicated pathologies do not need such a restrictive procedure. Exo-endoprosthesis is a suggested alternative for the enhancement of the biomechanical situation of these patients. 3D printing of the internal part of exo-endoprostheses in polyether ether ketone (PEEK) is evaluated. Two different shapes of this internal part—one for radius’ and the other for cylindrical medullary cavities—were assessed. Proper PEEK temperature settings for 3D printing, the internal part of exo-endoprostheses, by fused filament fabrication (FFF) were obtained. Printing trials were carried out for different dimensions and printing orientation of these parts to achieve the best bone anchorage and thread strength outcomes. Pull-off strength tests for different surfaces of the internal part were performed with a best outcome for positive surfaces. All printed internal parts were inserted in canine tibiae and radii for an ex vivo assessment of bone anchorage and thread strength parameters. The best printing results were obtained at 410 and 130°C of the nozzle and bed temperatures, respectively. Also, a positive correlation was observed between the printing code, quality, and take-off time, while inverse correlation was shown between the take-off and the printing code, or quality, just like the print-bed temperature and the printing code. The positive surfaces had the best pull-off strength outcomes. Excellent bone anchorage and thread strength outcomes were obtained for one variant of each internal part shape. Designed devices had shown good threaded rod’s fitting inside the PEEK plug and perfect bone anchorage of the PEEK plug for tibiae and radii. In addition, iteration of manufacturing PEEK small devices by FFF technology has been shown due to small standard deviation of most variants.

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Biomechanical Test of a New Endoprosthesis for Cylindrical Medullary Canals in Dogs

et al. 2022

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Exo-endoprosthesis is a limb salvage procedure for animals, although only expensive metal devices have been described. Now-a-days, new materials for this type of implant could be considered due to novel and affordable manufacturing techniques. However, a factor of safety (FoS) should be considered. There are kinetic and kinematic studies of canine natural gaits, which can be used to establish an FoS for mechanical tests for new non-metallic devices. Polyetheretherketone (PEEK) is used in different specialties in human medicine. Its mechanical properties (and its close mechanical stiffness to that of bone) make this polymer an alternative to metals in veterinary traumatology. PEEK could also be used in 3D printing. The suitability of a novel inner part of an exo-endoprosthesis manufactured by fuse deposition modeling (FDM) was presented in this study for long canine bones. Mechanical characterization of 3D-printed PEEK material and ex vivo mechanical tests of a customized endoprosthesis were performed to address it. Young's modulus of 3D-printed PEEK suffered a reduction of 30% in relation to bulk PEEK. Customized 3D-printed PEEK endoprostheses had promising outcomes for the tibiae of 20 kg dogs. Pure compression tests of the non-inserted endoprostheses showed a maximum force of 936 ± 199 N. In the bending tests of non-inserted endoprostheses, the PEEK part remained intact. Quasistatic mechanical tests of bone-inserted endoprostheses (compression-bending and pure compression tests) reached a maximum force of 785 ± 101 N and 1,642 ± 447 N, respectively. In fatigue tests, the samples reached 500,000 cycles without failure or detriment to their quasistatic results. These outcomes surpass the natural weight-bearing of dogs, even during a galloping pace. In conclusion, the 3D-printed PEEK part of the endoprosthesis for an exo-endoprosthesis can withstand loading, even during a galloping pace.

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Implantation of an Intraosseous Transcutaneous Amputation Prosthesis Restoring Ambulation After Amputation of the Distal Aspect of the Left Tibia in an Arabian Tahr (Arabitragus jayakari)

Cited by 4 publications

References 13 publications

Fibronectin grafting to enhance skin sealing around transcutaneous titanium implant

Fibronectin grafting to enhance skin sealing around transcutaneous titanium implant

Test of Designing and Manufacturing a Polyether Ether Ketone Endoprosthesis for Canine Extremities by 3D Printing

Biomechanical Test of a New Endoprosthesis for Cylindrical Medullary Canals in Dogs

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