Implantation treatment method of slow release anticancer doxorubicin containing hydroxyapatite (DOX-HAP) complex. A basic study of a new treatment for hepatic cancer

Kunieda, K; Seki, Toshihito; Nakatani, S; Wakabayashi, Masayuki; Shiro, Tomohiro; Inoue, Kenji; Sougawa, Mitsuharu; Kimura, Ryoji; Harada, Katsuhiro

doi:10.1038/bjc.1993.124

Cited by 27 publications

(21 citation statements)

References 18 publications

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“…Experiments are performed on the study of slow releasing anticancer drug implantation treatment as a new therapy for hepatocellular carcinoma. HAP was chosen as the carrier material for doxorubicin hydrochloride (DOX), an anticancer agent 5. DOX‐HAP was produced by adsorbing DOX on porous HAP particles of 1375 μm diameter using the freeze drying method.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of HAP/carboxymethyl chitosan nanocomposites

Sreedhar

Aparna

Sairam

et al. 2007

J of Applied Polymer Sci

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Nanocomposites of modified chitosan, carboxymethyl chitosan (CMCh) with hydroxyapatite (HAP) have been prepared by coprecipitation technique. Totally three nanocomposites containing 80/20, 50/50, and 20/80 of HAP/CMCh have been prepared and were characterized by using transmission electron microscopy (TEM), X-ray diffraction (XRD), fourier transformed infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), thermogravimetry (TG), and scanning electron microscopy (SEM). Modified chitosan, CMCh, which is water soluble can be used for drug delivery application. TEM micrographs of the nanocomposites revealed the formation of small HAP crystallites of about 230 nm in length and 30 nm in width that are aggregated to form elliptical shapes or morphology. TGA thermograms showed that the thermal stability of the CMCh increased with incorporation of HAP. FTIR, XRD, and XPS analysis of CMCh/HAP nanocomposites showed the peaks corresponding to CMCh as well as HAP and confirm the formation of HAP/CMCh nanocomposites.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of HAP/carboxymethyl chitosan nanocomposites

Sreedhar

Aparna

Sairam

et al. 2007

J of Applied Polymer Sci

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“…[28] These 1375f.lm particles each contain doxorubicin O.Img. Stable drug concentrations, in excess of 10 f.lg/g, were achieved at the implantation site for up to 21 days in experimental animals.…”

Section: Implantationmentioning

confidence: 99%

Clinical Pharmacokinetic Advantages of New Drug Delivery Methods for the Treatment of Liver Tumours

Anderson¹,

Warren²,

McArdle³

1994

Clinical Pharmacokinetics

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Response rates following systemic chemotherapy for hepatic tumours are disappointing. The drugs used have a narrow therapeutic ratio, which limit the scope for dose escalation of these potentially toxic agents. Therefore, alternative delivery methods that optimise the efficacy of currently available cytotoxic agents have been explored. Several novel approaches have attempted to 'target' treatment so that it reaches the tumour whilst minimising systemic exposure. There is some evidence to suggest that certain agents, including monoclonal antibodies and liposomes, selectively lodge in tumours following intravenous administration. Alternatively, the route of administration may be modified to enhance targeting of the administered drug. Delivery via the hepatic arterial, portal venous, and peritoneal routes as well as drug delivery via direct implantation may provide certain pharmacokinetic advantages. Infusion rates may be adjusted to optimise the pharmacokinetic profile. Chemoembolisation with microspheres, microcapsules or macromolecules might enhance targeting further. Variations in particle characteristics or by modifying hepatic arterial blood flow with vasoactive substances may be used to further refine this technique. The ultimate 'magic bullet', which allows total delivery of treatment to malignant cells whilst eliminating exposure of healthy tissues to these toxic agents, has not been developed as yet. However, currently available techniques allow considerable dose escalation that, whilst not providing a significant survival advantage, certainly improves response rates.

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“…Son varios los trabajos reportados acerca de la liberación de diversos medicamentos como los anticancerígenos (9)(10)(11)(12)(13)(14)(15)(16)(17)(18) y antibióticos (19)(20)(21)(22) incluyendo el estudio de los biomateriales en los cuales están soportadas dichas drogas.…”

Section: Diferentes Tipos De Sistemas (Biomateria-droga)unclassified

Sistemas biomaterial-droga para la liberación controlada de antibióticos

Grenier¹,

González²

1994

biomedica

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RESUMENEn el presente trabajo se recogen las principales características de los sistemas de liberación sostenidade medicamentossoportadosen diferentes biomateriales y que son utilizados fundamentalmente en el tratamiento de lesiones óseas. Sobre la base de una revisión bibliográfica actualizada en este tema, se analizan en detalle los tipos de biomateriales más utilizados, así como las ventajas y desventajas que los mismos presentan en tal aplicación. SUMMARYThe purpose of this paper was to review the main characteristics of a drug delivery System supported on different biomaterials and particularly the systerns applied on the treatmet of bone diseases. The advantages and disadvantages of thistype of biomaterial utilised with this objective are analysed in detail, based on the study of up-to-date literature in this area.Actualmente, la administración local de medicamentos ha despertado gran atención debido a que constituye un método seguro y eficiente mediante el cual se obtienen efectos quimioterapéuticos superiores.En el-caso del uso local de antibióticos, se cuenta con varias formas de aplicación como son por ejemplo: el método de irrigación-succión encerrada (1.2); perfusión regional de un miembro (3); bombasdeantibióticos implantables (4), y más recientemente sistemas de liberación usando materiales que pueden retener el medicamento.Los sistemas de liberación controlada de medicamentos fueron concebidos debido a la necesidad de unaterapia local y actualmentevan adquiriendo cada vez más importancia debido a las diversas ventajas que presentan. Entre tales ventajas se encuentran las siguientes:Se logra una administración local de la droga.La acción de la droga es más efectiva, ya que a diferencia de la administración por vía oral o por perfusión, los virus u organismos extraños son atacados directamente. Evita segundas intervencionesSe logra un mayor control de la enfermedad en cuestión. traciones del medicamento por vía sistémica.

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Implantation treatment method of slow release anticancer doxorubicin containing hydroxyapatite (DOX-HAP) complex. A basic study of a new treatment for hepatic cancer

Cited by 27 publications

References 18 publications

Preparation and characterization of HAP/carboxymethyl chitosan nanocomposites

Preparation and characterization of HAP/carboxymethyl chitosan nanocomposites

Clinical Pharmacokinetic Advantages of New Drug Delivery Methods for the Treatment of Liver Tumours

Sistemas biomaterial-droga para la liberación controlada de antibióticos

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