“…The most commonly used access is transfemoral (TF), which is the first option in most centers; however, there is a group of patients in whom TF access is not possible due to the size, tortuosity, or calcification of the femoral vessel. As a consequence, non-TF access alternative routes have been developed, which include transapical, transaortic (TAo), axillary, subclavian, and transcarotid access 3,4 . There are studies where femoral access was associated with a lower 30-day and 1-year mortality rate in comparison with non-TF access 5,6 , while others compare TF access with TAo and transapical access, with higher 30-day and 1-year mortality being shown in the transapical group 7 .…”