Implanted-Port-Catheter-Related Sepsis Caused by<i>Acidovorax avenae</i>and Methicillin-Sensitive<i>Staphylococcus aureus</i>

Malkan, Alpin D.; Strollo, Wendy; Scholand, Stephen J.; Dudrick, Stanley J.

doi:10.1128/jcm.01093-09

Cited by 24 publications

(13 citation statements)

References 18 publications

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“…Acidovorax spp., one of the bacterial signatures identified as significantly different between case and control in this study, is a flagellated, gram negative acid degrading member of the phylum Proteobacteria. Although, not much is known about its clinical epidemiology and pathogenicity in humans, it has been reported to also degrade nitro-aromatic compounds (Malkan et al, 2009). A potential mechanism for the Acidovoraxadenoma association could relate to the induction of local inflammation by increased flagellar proteins resulting from the higher abundance of Acidovorax (Tanaka et al, 2003;Takakura et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

Sanapareddy

Legge

Jovov³

et al. 2012

The ISME Journal

189

161

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Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.

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Section: Discussionmentioning

confidence: 99%

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

Sanapareddy

Legge

Jovov³

et al. 2012

The ISME Journal

189

161

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“…Acidovorax may promote colon neoplasia through increased metabolism of nitro-aromatic compounds [70] in the gut as well as induction of local inflammation by its flagellar proteins [71, 72]. …”

Section: Specific Gut Bacteria Adenoma and Crcmentioning

confidence: 99%

Gut Microbiome and Colorectal Adenomas

Dulal¹,

Keku²

2014

The Cancer Journal

103

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The trillions of bacteria that naturally reside in the human gut collectively constitute the complex system known the gut microbiome, a vital player for the host’s homeostasis and health. However, there is mounting evidence that dysbiosis, a state of pathological imbalance in the gut microbiome is present in many disease states. In this review, we present recent insights concerning the gut microbiome’s contribution to the development of colorectal adenomas and the subsequent progression to colorectal cancer (CRC). In the United States alone, CRC is the second leading cause of cancer deaths. As a result, there is a high interest in identifying risk factors for adenomas, which are intermediate precursors to CRC. Recent research on CRC and the microbiome suggest that modulation of the gut bacterial composition and structure may be useful in preventing adenomas and CRC. We highlight the known risk factors for colorectal adenomas and the potential mechanisms by which microbial dysbiosis may contribute to the etiology of CRC. We also underscore novel findings from recent studies on the gut microbiota and colorectal adenomas along with current knowledge gaps. Understanding the microbiome may provide promising new directions towards novel diagnostic tools, biomarkers, and therapeutic interventions for CRC.

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“…Patients with current H. pylori infection exhibited a decrease in the abundance of Acidovorax and Rhodococcus and an increase in Gemella and Erysipelotrichaceae UCG 004 [46]. This is an interesting finding, as Rhodococcus is an opportunistic pathogen and Acidovorax has been linked to colorectal neoplasia owing to its ability to increase the metabolism of nitro-aromatic compounds and trigger the immune response [47], while Gamella and Erysipelotrichaceae are members of commensal oral and gut microflora, respectively [5,48].…”

Section: Microbiota In Gastritismentioning

confidence: 94%

Microbiota Alterations in Gastrointestinal Cancers

2020

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Commensal microbiota plays a critical role in the maintenance of human health. Microbes influence energy metabolism and nutrient absorption and help defend the host organism against pathogens. The composition of the gut microbiota is delicately balanced, and any alterations may lead to proinflammatory immune responses and initiation of disease processes, including cancer. Experimental evidence indicates that the human intestinal microbiota can influence tumour development and progression in the gastrointestinal tract by damaging DNA, activation of oncogenic signaling pathways, production of tumour-promoting metabolites, and suppression of the anti-tumour immune response. The aim of this article was to outline differences in human microbiota between healthy subjects and patients with gastrointestinal malignancies such as esophageal, stomach, liver, biliary tract, pancreas and colon inflammations, and cancers. A better understanding of microbiota changes in various gastrointestinal malignancies will enable a greater insight into the relationship between human microbiota composition and cancer development.

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Implanted-Port-Catheter-Related Sepsis Caused byAcidovorax avenaeand Methicillin-SensitiveStaphylococcus aureus

Cited by 24 publications

References 18 publications

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

Gut Microbiome and Colorectal Adenomas

Microbiota Alterations in Gastrointestinal Cancers

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