Implantes de hidroxiapatita em falhas ósseas produzidas no fêmur de ratos submetidos ao tabagismo passivo

Pinheiro, Thiago Cerizza; Santos, Felipe Faganelli Caboclo dos; Shirane, Henrique Yassuhiro; Cunha, Marcelo Rodrigues da

doi:10.1590/s0102-36162008001000003

Cited by 6 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Camilli et al (23) implanted hydroxyapatite subperiosteally in the femur of rats and observed good bone neoformation in the area of the implant, as well as biocompatibility. Similar results were also described by Pinheiro et al (24) from implantation of hydroxyapatite in a bone defect created experimentally in the distal third of rats. Cunha et al (8) implanted collagen in defects in the femur of rats and noted that there was good closure of the area because large quantities of bone had formed.…”

Section: Discussionsupporting

confidence: 89%

“…Raab et al (25) stated that the mechanical function of the bone influenced the resistance and formation of the bone tissue. Thus, it can be seen in the literature that most studies on biomaterials have used the femur and tibia of rats because of their good biomechanical capacity and endochondral origin, which is important for the osteogenic function of the bone 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Biomaterial Implants in Bone Fractures Produced in Rats Fibulas

Shirane

Oda

Pinheiro

et al. 2010

Revista Brasileira de Ortopedia (English Edition)

Self Cite

View full text Add to dashboard Cite

To evaluate the importance of collagen and hydroxyapatite in the regeneration of fractures experimentally induced in the fibulas of rats. Method: 15 rats were used. These were subjected to surgery to remove a fragment from the fibula. This site then received a graft consisting of a silicone tubes filled with hydroxyapatite and collagen. Results: Little bone neoformation occurred inside the tubes filled with the biomaterials. There was more neoformation in the tubes with collagen. Conclusion: The biomaterials used demonstrated biocompatibility and osteoconductive capacity that was capable of stimulating osteogenesis, even in bones with secondary mechanical and morphological functions such as the fibula of rats.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Biomaterial Implants in Bone Fractures Produced in Rats Fibulas

Shirane

Oda

Pinheiro

et al. 2010

Revista Brasileira de Ortopedia (English Edition)

Self Cite

View full text Add to dashboard Cite

show abstract

“…According to Frayssinet et al (1992) the health conditions of bone are fundamental for its interaction with the implant biomaterial. Factors that increase the risk for osteoporosis development include a low calcium intake, smoking, alcoholism, lack of physical activity, and hormonal disorders resulting from early menopause or late menarche (Pinheiro et al, 2008;Shen et al, 2000). The risk of osteoporosis is also increased with ovariectomization (Lincoln and Tyler, 1999), considering that female gonadal hormones such as estrogen stimulate bone growth and mineralization (Wronski et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

View full text Add to dashboard Cite

2012Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats MICROSCOPY RESEARCH AND TECHNIQUE, MALDEN, v. 75, n. 2, pp. 133-137, FEB, 2012 http://www.producao.usp.br/handle/BDPI/42523 ABSTRACT Osteoporosis is a global public health that affects postmenopausal women due to the deficiency of estrogen, a hormone that plays an important role in the microarchitecture of bone tissue. Osteoporosis predisposes to pathological bone fracture that can be repaired by conventional methods. However, depending on the severity and quantity of bone loss, the use of autogenous grafts or biomaterials such as hydroxyapatite might be necessary. The latter has received increasing attention in the medical field because of its good biological properties such as osteoconductivity and biocompatibility with bone tissue. The objective of this study was to evaluate using histologic and radiographic analyses, the osteogenic capacity of hydroxyapatite implanted into the femur of rats with ovariectomy-induced osteoporosis. Eighteen rats were divided into three groups with six animals in each: group nonovariectomized, bilaterally ovariectomized not receiving estrogen replacement therapy, and bilaterally ovariectomized submitted to estrogen replacement therapy. Defects were created experimentally in the distal epiphysis of the femur with a surgical drill and filled with porous hydroxyapatite granules. The animals were sacrificed 8 weeks after surgery. The volume of newly formed bone in the implant area was quantified by morphometrical methods. The results were analyzed by ANOVA followed by the Tukey test (P < 0.05). The hydroxyapatite granules showed good radiopacity. Histological analysis revealed less quantity of newly formed bone in the ovariectomized group not submitted to hormone replacement therapy. In conclusion, bone neoformation can be expected even in bones compromised by estrogen deficiency, but the quantity and velocity of bone formation are lower. Microsc. Res. Tech. 75:133-137, 2012. V

show abstract

“…Defeitos com perda de massa óssea frequentemente são reparados com enxertos ósseos autógenos. No entanto, eles apresentam algumas desvantagens, como morbidade da área doadora, reabsorção pósoperatória, contornos irregulares dos enxertos angulares e complicações como dor crônica e lesões vasculares durante o procedimento cirúrgico [2]. Diante disto, têm se buscado biomateriais hábeis para promover esta substituição, evitando o uso de enxertos ou transplantes ósseos [3].…”

Section: Introductionunclassified

Desenvolvimento e caracterização de esferas de quitosana/ Dysphania ambrosioides (L.) Mosyakin & Clemants

et al. 2020

View full text Add to dashboard Cite

RESUMO O objetivo do presente trabalho foi produzir e caracterizar um biomaterial na forma de esferas de quitosana/ Dysphania ambrosioides (L.) Mosyakin & Clemants (mastruz) a fim de associar características positivas de ambos materiais, a quitosana com potencial osteoindutor e o mastruz capacidade de regeneração óssea, formando biomaterial a ser utilizado na formação e regeneração óssea. A planta foi coletada, identificada botanicamente e obtido extrato alcoólico bruto de Dysphania ambrosioides (L.) Mosyakin & Clemants (EAB). Para produção das esferas de quitosana e quitosana com EAB utilizou-se a técnica de Gelificação Ionotrópica. As esferas foram divididas em três grupos: um grupo de quitosana pura, outro com concentração menor de EAB e o terceiro com a maior concentração de EAB. Estas foram caracterizadas por Microscopia Óptica (MO), Microscopia Eletrônica de Varredura (MEV) e análise do Grau de Intumescimento (GI). A MO evidenciou nas superfícies externa e interna, esferas com limites definidos e com mudança de cor à medida que o percentual do EAB foi aumentado, tornando-se mais escuras. A MEV revelou, em esferas de maior concentração, quando comparado as de menor concentração: uma diminuição no tamanho e aumento da quantidade e da intercomunicação dos poros, além da alteração do formato geométrico tanto das esferas quanto dos seus poros. Na análise do Grau de intumescimento não houve diferenças significativas entre os grupos. Conclui-se que foi possível a produção de esferas de quitosana e quitosana/ Dysphania ambrosioides (L.) Mosyakin & Clemants (mastruz), que no grupo com maior percentual de EAB as amostras apresentaram-se mais escuras e com maior quantidade e intercomunicação dos poros e que embora tenha havido o intumescimento, não foi observada diferença significativa entre os grupos.

show abstract

Implantes de hidroxiapatita em falhas ósseas produzidas no fêmur de ratos submetidos ao tabagismo passivo

Cited by 6 publications

References 23 publications

Biomaterial Implants in Bone Fractures Produced in Rats Fibulas

Biomaterial Implants in Bone Fractures Produced in Rats Fibulas

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Desenvolvimento e caracterização de esferas de quitosana/ Dysphania ambrosioides (L.) Mosyakin & Clemants

Contact Info

Product

Resources

About