Empowerment is an effort made by the authorities, regional Governments, the commercial enterprise global, and the community synergistically within the shape of climate boom and enterprise development for Micro, Small and Medium businesses in order that they're able to develop and develop into strong and independent businesses. Efforts to increase MSMEs require actual cooperation among the government, both valuable and local, on the only hand, and the business global and the network on the other. The role of the authorities in this situation is visible in the provision of concrete facilities to MSMEs and of direction also thru the formation of laws and policies that favour MSMEs. The reason of this research is to explain the implementation of MSME empowerment in Manado town and analyse the elements that have an impact on the implementation of MSME empowerment in Manado town. The studies method uses descriptive qualitative with commentary, interview and report collection techniques. The concept utilized by George C Edward III's public coverage implementation on coverage implementation is encouraged by four variables, specifically: (1) verbal exchange, (2) bureaucratic shape, (3) assets, (4) disposition. The influencing factors use Merilee S. Grindle's theory, particularly the policy content material includes the interests of the goal institution, the type of gain, the preferred degree of trade, the vicinity of selection making, implementation, the assets worried. The outcomes of the research on the implementation of MSME empowerment in Manado town show that conversation relations are executed intensively and always, and are supported with the aid of the involvement of stakeholders, non-public and non-governmental organizations and the usage of whatsapp technology media as a way of communique. The formation of an implementing shape and a clean division of duties, and supported by way of human resources and non-human assets, as well as the formation of hierarchical imposing dispositions and tendencies to stakeholders and enthusiastic implementing attitudes in implementing MSME empowerment guidelines.