“…To a large extent, this shift has occurred in an environment of increased efforts to reduce the adverse consequences of prescription opioids (Compton et al, 2016), including improved prescriber education (Alford et al, 2015; ONDCP, 2014), strengthening of prescription drug monitoring programs (Brady et al, 2014; Davis et al, 2014; Surratt et al, 2014), targeted law enforcement activities (Florida Department of Law Enforcement, 2012; Hall, 2015; Surratt et al, 2014), abuse-deterrent opioid formulations (Cicero et al, 2012a), the development and implementation of opioid prescribing guidelines (Frieden and Houry, 2016), and stewardship programs in healthcare settings to reduce the supply of opioids (Ghafoor et al, 2013). Although there is evidence to suggest that these types of initiatives have contributed to reductions in NMPOU and diversion of prescription opioids (Delcher et al, 2015; Rutlow et al, 2015; Surratt et al, 2014) their role in rising heroin use is unclear.…”