Abstract:The research describes an intelligent electrocardiogram (ECG) acquisition system with low power and low data loss features. The system is constructed with ADS129X, MSP430X, CC254X Bluetooth low energy (BLE) with low power wireless communication protocol and smart phone for the ECG display. Two architectures, namely, with and without the microprocessor (MPU) and hinted handoff mechanism algorithm, are used to verify the data transmission loss between the BLE and the smart phone. The system not only employed low-power solution but also added full handshake and hinted handoff to achieve complete synchronization and accurate transmission reliability. The MPU method definitely enhanced the ECG packet loss rate and power saving rate to 0.63% and 49.78%, respectively.