As a novel structural damper, the unique structural characteristics of the integral squeeze film damper (ISFD) solve the nonlinear problem of the traditional squeeze film damper (SFD), and it has good linear damping characteristics. In this research, the experimental studies of ISFD vibration reduction performance are carried out for various working conditions of unbalanced rotors. Two ball bearing-rotor system test rigs are built based on ISFD: a rigid rotor test rig and a flexible rotor test rig. When the rotational speed of rigid rotor is 1500 rpm, ISFD can reduce the amplitude of the rotor by 41.79%. Under different unbalance conditions, ISFD can effectively improve the different degrees of unbalanced faults in the rotor system, reduce the amplitude by 43.21%, and reduce the sensitivity of the rotor to unbalance. Under different rotational speed conditions, ISFD can effectively suppress the unbalanced vibration of rigid rotor, and the amplitude can be reduced by 53.51%. In the experiment of the unbalanced response of the flexible rotor, it is found that ISFD can improve the damping of the rotor system, effectively suppress the resonance of the rotor at the critical speed, and the amplitude at the first-order critical speed can be reduced by 31.72%.