2022
DOI: 10.1002/cre2.603
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Implementing of aMMP‐8 point‐of‐care test with a modified new disease classification in Finnish adolescent cohorts

Abstract: Objectives: Periodontitis is a multifactorial biofilm-induced inflammatory disease; however, clinical and radiographic information reflects events that have already occurred. aMMP-8 lateral-flow chairside or point-of-care-test (POC-test) results have also come to complement the overall status of the patient's current situation. The current study aimed to clarify the usefulness of aMMP-8 chairsidetest (aMMP-8 POCT) results to alert the initial or early periodontitis in adolescents, a potential periodontitis ris… Show more

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Cited by 7 publications
(3 citation statements)
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“…With regard to periodontal diagnosis and therapy, some basic approaches to screen for biochemical or molecular factors in biological fluids, such as saliva or gingival crevicular fluid (GCF), have been implemented over time, reaching even the clinical market on a few occasions. As such, antibody-based host–enzyme detection assays for granulocyte-derived active matrix metalloproteinase (MMP)-8 in biological fluids can serve as good predictors of undiagnosed periodontitis, potentially with higher specificity than some of the clinical parameters [ 23 26 ]. Enzyme-based assays for bacterial protease activity in saliva or GCF may predict the presence of certain periodontal pathogens at the level of the affected site or patient [ 27 , 28 ].…”
Section: Current State Of Personalized Oral Healthcarementioning
confidence: 99%
“…With regard to periodontal diagnosis and therapy, some basic approaches to screen for biochemical or molecular factors in biological fluids, such as saliva or gingival crevicular fluid (GCF), have been implemented over time, reaching even the clinical market on a few occasions. As such, antibody-based host–enzyme detection assays for granulocyte-derived active matrix metalloproteinase (MMP)-8 in biological fluids can serve as good predictors of undiagnosed periodontitis, potentially with higher specificity than some of the clinical parameters [ 23 26 ]. Enzyme-based assays for bacterial protease activity in saliva or GCF may predict the presence of certain periodontal pathogens at the level of the affected site or patient [ 27 , 28 ].…”
Section: Current State Of Personalized Oral Healthcarementioning
confidence: 99%
“…These findings suggest that there is potential utility in the examination of oral fluid biomarkers to detect and better understand the biology of periodontitis in patients with and without T2DM 11–16 . Measurement of oral fluid biomarker concentrations also can provide clinical insight into the transition to periodontitis and early responses to treatment at the biological level, 14,17,18 which could serve as an important component of chairside diagnostics 19–24 . However, despite pro‐inflammatory (i.e., interleukin [IL]‐1b, and IL‐6) and collagen degradation (i.e., matrix metalloprotease [MMP]‐8) biomarker levels being detected in saliva of periodontitis patients without T2DM, 13,15,16,20,25 their presence in patients with T2DM, and their relationship with resistin, which is linked to obesity and diabetes, have not been fully explored with respect to severity of periodontitis or response to therapy 26–33 .…”
Section: Introductionmentioning
confidence: 99%
“…[11][12][13][14][15][16] Measurement of oral fluid biomarker concentrations also can provide clinical insight into the transition to periodontitis and early responses to treatment at the biological level, 14,17,18 which could serve as an important component of chairside diagnostics. [19][20][21][22][23][24] However, despite pro-inflammatory (i.e., interleukin [IL]-1b, and IL-6) and collagen degradation (i.e., matrix metalloprotease [MMP]-8) biomarker levels being detected in saliva of periodontitis patients without T2DM, 13,15,16,20,25 their presence in patients with T2DM, and their relationship with resistin, which is linked to obesity and diabetes, have not been fully explored with respect to severity of periodontitis or response to therapy. [26][27][28][29][30][31][32][33] Thus, advances in this field require pre-and post-treatment studies in diverse populations that include diabetic patients and a profile of biomarkers that have important regulatory roles in inflammation, tissue destruction, and insulin resistance.…”
Section: Introductionmentioning
confidence: 99%