2010
DOI: 10.1051/medsci/2010264397
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Implication du stress du réticulum endoplasmique en transplantation d’organe solide

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Cited by 4 publications
(3 citation statements)
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“…Complications associated with prolonged use of cyclosporine in transplant patients include hyperlipidemia, hypertension and severe nephrotoxicity 59 . It is well documented that the UPR is activated in solid organ transplantation 60 , 61 . The results of the present study uncovered molecular mechanisms of how cyclosporine activates UPR by demonstrating the ability of cyclosporine to regulate the RNA splicing activity of IRE1α via COX-2.…”
Section: Discussionmentioning
confidence: 99%
“…Complications associated with prolonged use of cyclosporine in transplant patients include hyperlipidemia, hypertension and severe nephrotoxicity 59 . It is well documented that the UPR is activated in solid organ transplantation 60 , 61 . The results of the present study uncovered molecular mechanisms of how cyclosporine activates UPR by demonstrating the ability of cyclosporine to regulate the RNA splicing activity of IRE1α via COX-2.…”
Section: Discussionmentioning
confidence: 99%
“…(35,36) The above mentioned stress is involved in post transplant diabetes, promoting insulin resistance and cells death. Insulin secerning cells undergo proteins synthesis stress and are very sensitive to any status causing accumulation of anomalous proteins.…”
Section: Immunosuppression and Cardiovascular Risk Factorsmentioning
confidence: 99%
“…Insulin secerning cells undergo proteins synthesis stress and are very sensitive to any status causing accumulation of anomalous proteins. The pathophisiology of pancreatic beta cells damage during treatment with Tacrolimus and Cyclosporine is still matter of debate, but it seems related to the endoplasmic reticulum stress which modify cells vitality, since in animal models treated with calcineurin inhibitors, nuclear inclusions, dilatation in cistern of the granulous endoplasmic reticulum with degranulation and degeneration of pancreatic beta islets have been shown (35,36) Steroids are often used in immunosuppressive therapeutic schemes in the perioperative period, both intraoperatively, and after transplantation for a period ranging from 3 to 6 months for liver transplantation. Moreover, at the possible onset of acute rejection, bolus of steroids are administered.…”
Section: Immunosuppression and Cardiovascular Risk Factorsmentioning
confidence: 99%