Implication of inflammatory cytokines in the aqueous humour for management of macular diseases

Qian, Yi; Wang, Yanyan; Chen, Lishuang; Li, Wen-Die; Shen, Yu; Jin, Yuanhui; Yang, Jie; Wang, Yuwen; Yuan, Jianshu; Cheng, Lingyun

doi:10.1111/aos.14248

Cited by 22 publications

(27 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the retina, we found that 4 molecules were upregulated in systemic hypoxia: VEGF, IL-1β, IL-22, and MCP3. Retinal immune profiling for systemic hypoxia has not previously been reported prior to our study, but upregulation of immune molecules such as VEGF and IL-1 has been wellreported in retinal vascular diseases associated with hypoxia, such as proliferative diabetic retinopathy [59,60], macular edema associated with branch retinal vein occlusion [61] and central retina vein occlusion [62][63][64]. IL-6, TNF-α and IL-1β upregulation and evidence of CNS inflammation have been well-reported in animal models of systemic hypoxia [65][66][67].…”

Section: Discussionmentioning

confidence: 59%

Hypoxia-induced inflammation: Profiling the first 24-hour posthypoxic plasma and central nervous system changes

et al. 2021

View full text Add to dashboard Cite

Central nervous system and visual dysfunction is an unfortunate consequence of systemic hypoxia in the setting of cardiopulmonary disease, including infection with SARS-CoV-2, high-altitude cerebral edema and retinopathy and other conditions. Hypoxia-induced inflammatory signaling may lead to retinal inflammation, gliosis and visual disturbances. We investigated the consequences of systemic hypoxia using serial retinal optical coherence tomography and by assessing the earliest changes within 24h after hypoxia by measuring a proteomics panel of 39 cytokines, chemokines and growth factors in the plasma and retina, as well as using retinal histology. We induced severe systemic hypoxia in adult C57BL/6 mice using a hypoxia chamber (10% O2) for 1 week and rapidly assessed measurements within 1h compared with 18h after hypoxia. Optical coherence tomography revealed retinal tissue edema at 18h after hypoxia. Hierarchical clustering of plasma and retinal immune molecules revealed obvious segregation of the 1h posthypoxia group away from that of controls. One hour after hypoxia, there were 10 significantly increased molecules in plasma and 4 in retina. Interleukin-1β and vascular endothelial growth factor were increased in both tissues. Concomitantly, there was significantly increased aquaporin-4, decreased Kir4.1, and increased gliosis in retinal histology. In summary, the immediate posthypoxic period is characterized by molecular changes consistent with systemic and retinal inflammation and retinal glial changes important in water transport, leading to tissue edema. This posthypoxic inflammation rapidly improves within 24h, consistent with the typically mild and transient visual disturbance in hypoxia, such as in high-altitude retinopathy. Given hypoxia increases risk of vision loss, more studies in at-risk patients, such as plasma immune profiling and in vivo retinal imaging, are needed in order to identify novel diagnostic or prognostic biomarkers of visual impairment in systemic hypoxia.

show abstract

Section: Discussionmentioning

confidence: 59%

Hypoxia-induced inflammation: Profiling the first 24-hour posthypoxic plasma and central nervous system changes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In addition, models of glaucoma have shown the presence of macrophages and T-lymphocytes in the eye along with autoantibodies to proteins of the retina [3,4,29,30]. Models of RP have also shown similar features, including monocytic phagocytosis of both diseased and healthy retinal cells as well as numerous cytokines such as interleukin-1, interleuken-6, vascular endothelial growth factor, and others [4,31,32]. While the molecular mechanisms of the primary genetic assault have been teased out by copious amounts of work using cell culture and animal models for many RDs (i.e., loss of outer segment formation, disrupted visual cycle, etc.)…”

Section: Discussionmentioning

confidence: 98%

Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy

Hollingsworth

Gross

2020

Cells

View full text Add to dashboard Cite

Inherited retinal dystrophies (RDs) are heterogenous in many aspects including genes involved, age of onset, rate of progression, and treatments. While RDs are caused by a plethora of different mutations, all result in the same outcome of blindness. While treatments, both gene therapy-based and drug-based, have been developed to slow or halt disease progression and prevent further blindness, only a small handful of the forms of RDs have treatments available, which are primarily for recessively inherited forms. Using immunohistochemical methods coupled with electroretinography, optical coherence tomography, and fluorescein angiography, we show that in rhodopsin mutant mice, the involvement of both the innate and the autoimmune systems could be a strong contributing factor in disease progression and pathogenesis. Herein, we show that monocytic phagocytosis and inflammatory cytokine release along with protein citrullination, a major player in forms of autoimmunity, work to enhance the progression of RD associated with a rhodopsin mutation.

show abstract

“…Although the pathogenic causes of RVO are unknown, it is hypothesized that inflammatory indicators play an important role in the disease’s onset. Several inflammatory factors, including IL6, IL8, ICAM-1, MCP-1, IL1-, IL 17-E, and TNF-α, were found to be higher in the aqueous or vitreous of RVO eyes [ 6 – 8 ], prompting the FDA to approve an anti-inflammatory drug (Ozurdex, an intravitreal dexamethasone implant) for treating macular edema following RVO in 2009. As a result, several prospective trials have shown the efficacy and safety of an intravitreal dexamethasone implant for the treatment of RVO-related macular edema [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Qin

Zhang

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

Aim To evaluate the association between the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) and the development of retinal artery occlusion (RAO) and retinal vein occlusion (RVO). Methods This retrospective study assessed 41 RAO, 50 RVO and 50 control (age and gender matched senile cataract) participants. The NLR, PLR and MHR parameters of patients’ peripheral blood were analyzed. A receiver operating characteristics (ROC) curve analysis and the best cutoff value were used to specify the predictive value of NLR, PLR and MHR in RAO and RVO. Results The NLR, PLR and MHR were significantly higher in RAO group compared to the control group (p<0.001, p<0.001 and p = 0.008; respectively). The NLR, PLR and MHR were also significantly higher in the RVO group compared to the control group (p<0.001, p = 0.001 and p = 0.012, respectively). The NLR and PLR were significantly higher in the RAO group compared to the RVO group (p<0.001 and p = 0.022, respectively). The optimal cut-off value of NLR to predict RAO was >2.99, with 90.2% sensitivity and 100% specificity. The PLR to predict RAO was > 145.52, with 75.6% sensitivity and 80.0% specificity. Conclusion Higher NLR, PLR and MHR are related to the occurrence of RAO and RVO. NLR and PLR are more prominent in RAO compared to RVO.

show abstract

Implication of inflammatory cytokines in the aqueous humour for management of macular diseases

Cited by 22 publications

References 32 publications

Hypoxia-induced inflammation: Profiling the first 24-hour posthypoxic plasma and central nervous system changes

Hypoxia-induced inflammation: Profiling the first 24-hour posthypoxic plasma and central nervous system changes

Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Contact Info

Product

Resources

About