Implication of Monoclonal Antibody for COVID-19 Treatment

Novel coronavirus disease caused by the SARS-CoV-19 virus enters the host cell through the S-spike protein by binding to ACE-2. In December 2019, an outbreak of coronavirus originated from Wuhan, China and by the end of 2020, it was recorded in almost every part of the world including Italy, Germany, Iran, Spain, and also United states. This led to a Pandemic which was declared by World Health Organization on 11th March 2020. SARS-CoV-19 causes mild to moderate illness which leads to acute respiratory syndrome, by causing infection in the nose, sinuses, or upper throat. It can also affect the upper or lower respiratory tract and has caused millions of cases and deaths. Many diagnostic tests have been authorized by the WHO including Direct and Indirect tests. Due to the increase in the number of covid 19 cases, many medications were introduced as per the demands like anti-malarial drugs, anti-viral drugs, antibiotics, anti-inflammatory drugs, steroids, biological agents, etc. The SARS-CoV-2 has a spike protein on its surface that aids in the virus's attachment to and entry into human cells. To attach to the protein of SARS-spike-CoV-2 and stop the virus from infecting human cells, many monoclonal antibodies like Casirivimab, imdevimab, Tocilizumab, Sarilumab, Itolizumab, Siltuximab have been created. As monoclonal antibodies prevent viruses from entering cells and continuing to proliferate, as well as lowering viral loads and lowering the frequency of hospital visits, they can be used as an alternative to conventional therapies. Hence monoclonal antibody treatment can be considered an effective alternative treatment for treating SARS-CoV-2.

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“…Table 3: An overview of some monoclonal antibodies with their target site, route of administration, and outcome. 32…”

Section: The Action Of Monoclonal Antibodiesmentioning

confidence: 99%

A review on “monoclonal antibodies: effective treatment against COVID-19”

Dabhadkar

Palekar

Pawar

2022

Int J Community Med Public Health

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“…5 represents the waste amount, change in waste amount, disposal rate, and timing (temporal), distribution (spatial), and infection risk (Fan et al, 2021). An improper management of the wastes may be a threat associated to COVID-19 infection (Bhandary et al, 2020;Tuladhar, 2020).…”

Section: Plastic Waste Management During Covid-19 Periodmentioning

confidence: 99%

A Review on Current Practices of Plastics Waste Management and Future Prospects

Bhandari

Bhattarai

Bhandari

et al. 2021

J. Inst. Sci. Tech.

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Inefficient solid waste management of plastics and polymeric materials is one of the global challenges leading to environmental deterioration. This challenge has brought alarming concern to minimize volume of such wastes released into the environment. The concern proposes a solution to the existing problems to some extent by reuse, recycling, and efficient conversion of waste materials into alternative application. Chemical and thermo-mechanical conversion of plastic wastes into energy and their biodegradation were taken into account. Consequently, some newly employed recycling and conversion techniques of plastic wastes, and possible future alternatives with recommendations are reviewed in this article

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Implication of Monoclonal Antibody for COVID-19 Treatment

Cited by 2 publications

References 18 publications

A review on “monoclonal antibodies: effective treatment against COVID-19”

A review on “monoclonal antibodies: effective treatment against COVID-19”

A Review on Current Practices of Plastics Waste Management and Future Prospects

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